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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Phobias Spiders Clear all
Completed Not applicable Interventional

Optimizing Exposure Therapy With Mental Rehearsal

NCT03934385
View directory record Official record
Conditions
Anxiety Disorders, Arachnophobia
Interventions
Mental Rehearsal, Exposure
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Jul 22, 2026, 3:45 AM EDT
Not yet recruiting Not applicable Interventional

A Randomized Controlled Efficacy Trial of a Telemedicine-based Virtual Reality Clinic for the Treatment of Phobias

NCT07558824
View directory record Official record
Conditions
Specific Phobia, Animal
Interventions
Telemedicine-Based Virtual Reality Exposure Therapy, Telemedicine-Based Exposure Therapy Using Photos and Videos
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders

NCT01631682
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Anxiety Disorder
Interventions
Propranolol, Reactivation, Mifepristone, Intranasal oxytocin
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 35 Years
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Results available

Telemedicine-Based Virtual Reality Clinic for the Treatment of Phobias

NCT06302868
View directory record Official record
Conditions
Arachnophobia, Cynophobia, Ophidiophobia
Interventions
Telemedicine Exposure Therapy Using Photos and Videos, Telemedicine-Based Virtual Reality Exposure Therapy
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional

Efficacy of Targeted Memory Reactivation for Enhancing Exposure Therapy

NCT04663672
View directory record Official record
Conditions
Claustrophobia, Obsessive-Compulsive Disorder, Arachnophobia
Interventions
Experimental Scent, Control Scent, No-Scent Control, In-Vivo Exposure
Other · Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional

The Effects of Safety Seeking Behaviors During Exposure Therapy for Adults With Spider Phobia

NCT03233113
View directory record Official record
Conditions
Specific Phobia
Interventions
Exposure therapy
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Jul 22, 2026, 3:45 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

3D Video Virtual Reality Exposure Therapy Study

NCT02584387
View directory record Official record
Conditions
Acrophobia, Arachnophobia
Interventions
3D Video Virtual Reality Exposure Therapy
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional

Use of Safety Behaviors in Exposure Therapy for Arachnophobia

NCT04470882
View directory record Official record
Conditions
Specific Phobia, Arachnophobia, Spider Phobia
Interventions
Exposure with faded safety behaviors, Exposure without safety behaviors, Exposure with unfaded safety behaviors
Behavioral
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 17, 2021 · Synced Jul 22, 2026, 3:45 AM EDT
Terminated Not applicable Interventional Results available

TMS and Exposure Therapy

NCT04019054
View directory record Official record
Conditions
Arachnophobia, Phobia
Interventions
Intermittent Theta Burst Stimulation (iTBS), Ventromedial Prefrontal Cortex (vmPFC), Intermittent Theta Burst Stimulation (iTBS), vertex
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

tDCS-Augmented Exposure Therapy for Pathological Fear

NCT03095482
View directory record Official record
Conditions
Specific Phobias
Interventions
Transcranial Direct Current Stimulation (tDCS), In vivo exposure therapy
Device · Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Terminated Not applicable Interventional Results available

Bringing Exposure Therapy to Real-Life Context With Augmented Reality

NCT03649347
View directory record Official record
Conditions
Phobias Snakes, Phobias Spiders
Interventions
Augmented reality exposure therapy
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 18, 2022 · Synced Jul 22, 2026, 3:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Spider Phobia Opposite Action Treatment Study

NCT02905279
View directory record Official record
Conditions
Specific Phobia
Interventions
Biofeedback Relaxation Training, Exposure Therapy, Exposure with Threat-Relevant Opposite Actions, Exposure with Threat-Irrelevant Opposite Actions
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Enhancing Exposure Therapy for Snake and Spider Phobias

NCT02160470
View directory record Official record
Conditions
Specific Phobia
Interventions
Exposure Therapy with Retrieval, Exposure Therapy with Compound Extinction, Exposure Therapy with Retrieval and Compound Extinction, Therapist-guided Exposure Therapy
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

fMRI Study Examining Effects of D-cycloserine in Specific Phobia

NCT00591825
View directory record Official record
Conditions
Phobias
Interventions
D-cycloserine, Placebo
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2017 · Synced Jul 22, 2026, 3:45 AM EDT
Recruiting Phase 4 Interventional

The Effects of Propranolol and Hydrocortisone on Military-Relevant Performance Outcomes

NCT06982183
View directory record Official record
Conditions
Fear of Spiders, Acute Stress Reaction
Interventions
Propranolol, Hydrocortisone, Placebo (oral), Placebo (IM)
Drug
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 40 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional

One-session Treatment for Spider Fears

NCT03410264
View directory record Official record
Conditions
Spider Phobia
Interventions
CR-EXP, EXP-CR, Stress Management
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 7, 2021 · Synced Jul 22, 2026, 3:45 AM EDT