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Showing 1–24 of 101 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Photoaging of Skin Clear all
Not listed Phase 4 Interventional Accepts healthy volunteers

Altreno for Chest Rejuvenation

NCT04096742
View directory record Official record
Conditions
Photodamaged Skin, Photoaging
Interventions
tretinoin 0.05% lotion (Altreno), Vehicle
Drug · Other
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NanoSilk Cosmo: Evaluation of a Novel Silk Complex on Biophysical Parameters Related to Skin Aging

NCT04630418
View directory record Official record
Conditions
Aging
Interventions
NanoSilk Cosmo
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 99 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 13, 2023 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Retinol on Human Skin Aging in East Asian Descent

NCT02906566
View directory record Official record
Conditions
Intrinsic Aging of Skin
Interventions
Retinol, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Jul 22, 2026, 11:02 AM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

Effect of Platelet Rich Plasma on Photoaged Skin

NCT01372566
View directory record Official record
Conditions
Photoaging
Interventions
Harvest PRP Separation System, Sterile Saline injection
Device · Other
Lead sponsor
Northwestern University
Other
Eligibility
35 Years to 60 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2024 · Synced Jul 22, 2026, 11:02 AM EDT
Recruiting Not applicable Interventional

Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin

NCT06195605
View directory record Official record
Conditions
Photoaging
Interventions
Restylane-L, Vehicle
Device
Lead sponsor
University of Michigan
Other
Eligibility
30 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 7, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids

NCT01583478
View directory record Official record
Conditions
Skin Aging, Elastosis Senilis
Interventions
incobotulinumtoxinA
Biological
Lead sponsor
The Maas Clinic
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2014 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure

NCT01787461
View directory record Official record
Conditions
Photodamaged Skin
Interventions
Imedeen, Placebo
Dietary Supplement
Lead sponsor
Pfizer
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
4
States / cities
Miami, Florida • Fair Lawn, New Jersey • Lynchburg, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Jul 22, 2026, 11:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Human Skin Aging: Clinical Parameters and Gene Expression Profiling

NCT01451476
View directory record Official record
Conditions
Ageing
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Jul 22, 2026, 11:02 AM EDT
Not listed Not applicable Interventional Results available

Safety and Efficacy Evaluation of Erbium Treatment

NCT00766376
View directory record Official record
Conditions
Skin Aging
Interventions
Erbium laser
Device
Lead sponsor
Palomar Medical Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
5
States / cities
San Diego, California • Burlington, Massachusetts • Concord, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2010 · Synced Jul 22, 2026, 11:02 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Improve the Signs of Aging, by Comparing to a Placebo

NCT06804772
View directory record Official record
Conditions
Skin Aging
Interventions
Investigational Facial Serum #3, Investigational Facial Serum #1, Investigational Facial Serum #2
Other
Lead sponsor
Victoria Collotta
Industry
Eligibility
35 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dealcoholized Muscadine Wine and Skin Health in Women

NCT04614753
View directory record Official record
Conditions
Skin Health
Interventions
Dealcoholized Muscadine Wine, Control Beverage
Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 67 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Combination Versus Laser Treatment Only

NCT03661697
View directory record Official record
Conditions
Photoaging
Interventions
Laser Therapy, Basic Skin Care Regimen, Lytera
Device · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 3 Interventional

Safety and Efficacy of Botulinum Toxin Type A Topical Gel for Lateral Canthal Lines

NCT02580370
View directory record Official record
Conditions
Skin Aging
Interventions
Botulinum toxin type A, Placebo comparator
Biological
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Cryo-Touch III Refinement Study Investigational Plan

NCT01379365
View directory record Official record
Conditions
Facial Wrinkles, Skin Aging
Interventions
Cryo-Touch III
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
30 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Mar 23, 2015 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Safety and Tolerability of a Brightening Treatment Paired With a Skincare Regimen

NCT07501000
View directory record Official record
Conditions
Hyperpigmentation, Skin Ageing, Post Inflammatory Hyperpigmentation, Skin Roughness
Interventions
Brightening Treatment
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
20 Years to 65 Years · Female only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 22, 2026, 11:02 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Novel Dietary Ingredient on Hair Growth and Skin's Appearance

NCT06010745
View directory record Official record
Conditions
Hair Thinning, Facial Skin Texture, Skin Ageing
Interventions
Biotin and silicon, Placebo
Dietary Supplement
Lead sponsor
Nutrition 21, Inc.
Industry
Eligibility
35 Years to 70 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Jul 22, 2026, 11:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Skin Hydration and Facial Aging in Women Aged 30-60: An Observational Correlational Study Using Bioimpedance Analysis

NCT07564869
View directory record Official record
Conditions
Skin Aging, Skin Hydration, Facial Aging, Transepidermal Water Loss
Interventions
BT-Analyze Bioimpedance Measurement
Other
Lead sponsor
IAS Skin Care
Industry
Eligibility
30 Years to 60 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Winter Garden, Florida
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 4 Interventional Results available

Patient Satisfaction With Treatment of BOTOX® Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines

NCT00856414
View directory record Official record
Conditions
Skin Aging
Interventions
botulinum toxin Type A
Biological
Lead sponsor
Allergan
Industry
Eligibility
35 Years to 55 Years · Female only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
2
States / cities
West Palm Beach, Florida • Livonia, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 28, 2019 · Synced Jul 22, 2026, 11:02 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Improve the Signs of Aging

NCT06804759
View directory record Official record
Conditions
Skin Aging
Interventions
Investigational Facial Serum #1, Investigational Facial Serum #2, Investigational Facial Serum #3
Other
Lead sponsor
Victoria Collotta
Industry
Eligibility
35 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Pilot Study to Evaluate the Expanded Reach of Decentralized Digital Skin Health Clinical Studies

NCT07193290
View directory record Official record
Conditions
Skin Aging, Hair Care, Skin Microbiome
Interventions
Lifestyle Questionnaire, Self-portrait image (Face and Hair), Skin microbiome collection
Other · Diagnostic Test
Lead sponsor
Kenvue Brands LLC
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
1,027 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Apopka, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional

Clinical Study Evaluating the Safety and Effectiveness of the NIRA Laser M2.1 for the Treatment of Full-Face Wrinkles

NCT07572331
View directory record Official record
Conditions
Skin Ageing, Facial Wrinkles, Acne, Skin Elasticity, Infraorbital Dark Circle Severity, Skin Firmness, UV Spots, Skin Texture, Skin Pores, Brown Spots, Porphyrins, Red Spots
Interventions
NIRA Laser M2.1, Topical
Device · Other
Lead sponsor
NIRA Innovations Inc.
Industry
Eligibility
35 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Beverly, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Hybrid-Fractional Laser for Facial Rejuvenation

NCT06436261
View directory record Official record
Conditions
Photoaging, Wrinkle, Skin Laxity
Interventions
Hybrid Fractional Laser, Facial Cleanser, Facial Moisturizer, Sunscreen
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Atlanta, Georgia • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Pomegranate on Aging and Inflammation of the Skin

NCT02258776
View directory record Official record
Conditions
Skin Photoaging, Inflammation and Skin Pathogenic Bacteria
Interventions
Pomegranate Extract, Pomegranate Juice, Placebo
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
30 Years to 45 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 2 Interventional Results available

Eflornithine and/or Diclofenac in Treating Patients With Sun-Damaged Skin

NCT00601640
View directory record Official record
Conditions
Other Benign Neoplasm of Skin, Unspecified
Interventions
Diclofenac Na gel, Eflornithine HCL ointment
Drug
Lead sponsor
University of Arizona
Other
Eligibility
40 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
3
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 22, 2017 · Synced Jul 22, 2026, 11:02 AM EDT