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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Positive Pressure Ventilation Clear all
Completed Not applicable Interventional Results available

Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography

NCT01175031
View directory record Official record
Conditions
Sleep Apnea Central, Cheyne-Stokes Respiration, Obstructive Sleep Apnea
Interventions
Manipulation of Positive Airway Pressure (PAP)
Other
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Denver, Colorado • Gainesville, Florida • Portage, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Early Phase 1 Interventional

Promoting Continuous Positive Airway Pressure (CPAP) Adherence

NCT01335854
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Web-based Access to CPAP Data, Web-based Access to CPAP Data with Financial Incentive
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Wynnewood, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2014 · Synced Sep 26, 2026, 9:20 PM EDT
Completed No phase listed Observational

The Effect of Positive Airway Pressure on Heart Rate Variability

NCT00289666
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years to 75 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 10, 2016 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome

NCT03793842
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, ARDS
Interventions
Usual care, PEEP titration by EIT
Other · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Self-Management of Continuous Positive Airway Pressure Settings

NCT03536572
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Sleep Apnea Self-Management Program
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema

NCT04186598
View directory record Official record
Conditions
Continuous Positive Airway Pressure, High Altitude Pulmonary Edema
Interventions
CPAP mask system, Nifedipine 30 MG, CPAP mask system without PEEP
Device · Drug
Lead sponsor
CommonSpirit Health
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Breckenridge, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Sep 26, 2026, 9:20 PM EDT
Withdrawn Not applicable Interventional

Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation

NCT02492113
View directory record Official record
Conditions
Obesity
Interventions
Positive end-expiratory pressure (PEEP), ZEEP
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Monitoring Neonatal Resuscitation Trial

NCT03256578
View directory record Official record
Conditions
Resuscitation, Neonatal Prematurity, Positive-Pressure Respiration
Interventions
New Life Box Respiratory Function Monitor
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
24 Weeks to 28 Weeks
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 21, 2021 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness Study of Bubble CPAP Devices in the NICU

NCT02392806
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Bubble CPAP- BabiPlus, Respiralogics, Bubble CPAP- B&B Bubbler, B&B Medical devices
Device
Lead sponsor
Marya Strand, MD
Other
Eligibility
1 Day to 100 Days
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Sep 26, 2026, 9:20 PM EDT
Terminated Not applicable Interventional

Neotech RAM Cannula Versus Conventional Binasal Prong Continuous Positive Airway Pressure (CPAP) to Treat Respiratory Distress in Low Birth Weight Neonates

NCT02168257
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn, Continuous Positive Airway Pressure, Low Birth Weight Infants
Interventions
RAM Cannula, Binasal Prong CPAP
Device
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
Not listed
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 20, 2017 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional

Promoting the Use of CPAP Therapy Among OSA Patients

NCT04372329
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
CPAP4HealthySleep system
Behavioral
Lead sponsor
Sarah Alismail
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Claremont, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Sep 26, 2026, 9:20 PM EDT
Not listed No phase listed Observational

Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.

NCT04191512
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Thomas Jefferson University
Other
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 21, 2024 · Synced Sep 26, 2026, 9:20 PM EDT
Recruiting Not applicable Interventional

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

NCT05988385
View directory record Official record
Conditions
Obstructive Sleep Apnea, Cognitive Decline
Interventions
Positive airway pressure, Oral appliance therapy, Positional therapy
Device
Lead sponsor
California Pacific Medical Center Research Institute
Other
Eligibility
55 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Tucson, Arizona • New York, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional

ARDSnet Protocol vs. Open Lung Approach in ARDS

NCT00431158
View directory record Official record
Conditions
Respiratory Distress Syndrome, Adult
Interventions
Different Mechanical Ventilation Protocols
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 17, 2014 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Improving the Frequency and Quality of Sleep Apnea Care Management

NCT01916655
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Self-Management Care, Self-Management Mobile Care, Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 85 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Phase 3 Interventional

Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure

NCT00356668
View directory record Official record
Conditions
Respiratory Distress Syndrome, Cronic Lung Disease
Interventions
High Flow Nasal Cannula
Device
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
72 Hours and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 13, 2015 · Synced Sep 26, 2026, 9:20 PM EDT
Enrolling by invitation Not applicable Interventional

Personalized Ventilator Settings for Patients on ECMO

NCT07673250
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU, Ventilator Induced Lung Injury
Interventions
Personalized Positive End-Expiratory Pressure (PEEP)
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 26, 2026, 9:20 PM EDT
Withdrawn Not applicable Interventional

Effects of PAP on Afib Recurrence Risk After Catheter Ablation in OSA Patients

NCT03242720
View directory record Official record
Conditions
Obstructive Sleep Apnea, Atrial Fibrillation
Interventions
Cardiac Ablation for Atrial Fibrillation
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated May 23, 2022 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional

Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection

NCT04694638
View directory record Official record
Conditions
Prone Positioning, Covid19, Hypoxemic Respiratory Failure, ARDS, Non Invasive Ventilation, High Flow Nasal Cannulla
Interventions
Body position change
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 110 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Sep 26, 2026, 9:20 PM EDT
Terminated Not applicable Interventional Results available

NAVA Versus BiPAP Non-Invasive Respiratory Support in Infants Following Congenital Heart Surgery

NCT03180385
View directory record Official record
Conditions
Respiratory Failure
Interventions
Neurally-Adusted Ventilatory Assist (NAVA), Biphasic Positive Airway Pressure Support (BiPAP)
Device
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
Up to 12 Months
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Phase 2 Interventional

Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)

NCT05951023
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Eszopiclone 2 mg, Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury

NCT04221009
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Brain Injuries, Traumatic
Interventions
MI and CBT 4-session manualized intervention
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2024 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use

NCT01462084
View directory record Official record
Conditions
Obstructive Sleep Apnea, Central Sleep Apnea (Diagnosis), Chronic Opioid Use
Interventions
Adaptive servo-ventilation (ASV), Bi-Level PAP
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Sep 26, 2026, 9:20 PM EDT
Completed Not applicable Interventional Results available

Simple Non-invasive Breathing Device to Improve Pulmonary Flow Pusatility in Single Ventricle Post Fontan

NCT05634226
View directory record Official record
Conditions
Single-ventricle
Interventions
Hands-free oral-positive pressure device (oPEP)
Device
Lead sponsor
Tarek Alsaied
Other
Eligibility
8 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Sep 26, 2026, 9:20 PM EDT