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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Post Operative Analgesia Clear all
Completed Phase 4 Interventional Results available

Adductor Canal Block for Medial Compartment Knee Arthroplasty

NCT01818531
View directory record Official record
Conditions
Postoperative Analgesia, Medial Unicompartmental Knee Arthroplasty
Interventions
Adductor canal block, Lumbar plexus block
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 85 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Sep 17, 2026, 9:36 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Preemptive Use of the Nicotine Patch for Postoperative Pain Relief After Open Abdominal Surgery

NCT00790829
View directory record Official record
Conditions
Postoperative Pain
Interventions
transdermal nicotine patch
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Intrathecal Hydromorphone for Pain Control After Cesarean Section

NCT02096003
View directory record Official record
Conditions
Pain, Cesarean Section
Interventions
Intrathecal morphine, Intrathecal hydromorphone
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 17, 2026, 9:36 PM EDT
Terminated Phase 4 Interventional Results available

Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain

NCT02746263
View directory record Official record
Conditions
Acute Pain, Postoperative
Interventions
IV acetaminophen, Oral acetaminophen, Morphine
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
50 Years to 90 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
2
States / cities
Pensacola, Florida • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty

NCT05898087
View directory record Official record
Conditions
Macromastia, Post-operative Pain
Interventions
Marcaine 0.25 % Injectable Solution, Saline
Drug
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
13 Years to 25 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Farmington, Connecticut • Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 4 Interventional Results available

Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients

NCT01591382
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ketamine, Placebo, Hydromorphone PCA
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Results available

Percutaneous Auricular Neuromodulation for Postoperative Analgesia

NCT05521516
View directory record Official record
Conditions
Postoperative Pain, Acute
Interventions
Active Percutaneous Auricular Neuromodulation with NSS-2 Bridge, Sham Treatment
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation

NCT03995641
View directory record Official record
Conditions
Postoperative Pain, Pelvic Organ Prolapse, Trigger Point Injection, Sacrospinous Ligament Fixation
Interventions
marcaine and kenalog
Drug
Lead sponsor
Kettering Health Network
Other
Eligibility
21 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

Bupivacaine Hydrochloride for Pain Control in Cutaneous Surgery

NCT04260854
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine Hydrochloride, Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
19 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Not listed Not applicable Interventional

Medial Versus Traditional Approach to US-guided TAP Blocks for Open Inguinal Hernia Repair

NCT01589796
View directory record Official record
Conditions
Abdominal Muscles/Ultrasonography, Adult, Ambulatory Surgical Procedures, Anesthetics, Local/Administration & Dosage, Ropivacaine/Administration & Dosage, Ropivacaine/Analogs & Derivatives, Hernia, Inguinal/Surgery, Humans, Nerve Block/Methods, Pain Measurement/Methods, Pain, Postoperative/Prevention & Control, Ultrasonography, Interventional
Interventions
TAP block
Procedure
Lead sponsor
Stamford Anesthesiology Services, PC
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 1, 2012 · Synced Sep 17, 2026, 9:36 PM EDT
Terminated Phase 3 Interventional Results available

ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain

NCT03261193
View directory record Official record
Conditions
Pain, Postoperative
Interventions
ITM + Sham QLB, ITM + Bupivacaine QLB
Drug
Lead sponsor
Nicholas Schott
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2024 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional

Study to Evaluate ACB Versus FNB Early Postoperative Period Functional Outcomes After TKA

NCT02218814
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Nerve Block
Interventions
Adductor Canal Block, Bupivacaine, Femoral Nerve Block, Bupivacaine
Procedure
Lead sponsor
George Macrinici
Other
Eligibility
40 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Joliet, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 1, 2016 · Synced Sep 17, 2026, 9:36 PM EDT
Recruiting Phase 4 Interventional

Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following HTO/DFO/TTO

NCT06952556
View directory record Official record
Conditions
Analgesia
Interventions
ACB, IPACK block
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 3 Interventional

Pilot: Intraoperative TAP Block and Post-operative Pain Control for Minimally Invasive Hysterectomy for Endometrial Cancer

NCT05763667
View directory record Official record
Conditions
Post Operative Pain, Gynecologic Cancer
Interventions
Liposomal bupivacaine, Bupivacain
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Enrolling by invitation Phase 2Phase 3 Interventional

Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion

NCT06350981
View directory record Official record
Conditions
Back Pain, Surgery-Complications, Narcotic Use, Physical Stress, Post Operative Pain
Interventions
Exparel, Bupivacain
Drug
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 4 Interventional

Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery

NCT00508066
View directory record Official record
Conditions
Scoliosis
Interventions
Bupivacaine, Normal Saline
Drug
Lead sponsor
Shriners Hospitals for Children
Other
Eligibility
8 Years to 18 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 24, 2013 · Synced Sep 17, 2026, 9:36 PM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management

NCT07821931
View directory record Official record
Conditions
Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid, Postoperative Pain, Acute Pain
Interventions
Suzetrigine, Acetaminophen, oxycodone
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Results available

A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery

NCT01097577
View directory record Official record
Conditions
Postoperative Pain
Interventions
pregabalin, Placebo
Drug
Lead sponsor
59th Medical Wing
Federal
Eligibility
21 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Oct 27, 2020 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 3 Interventional Results available

Ketorolac in Postoperative Infants: Pharmacokinetics and Safety

NCT01260883
View directory record Official record
Conditions
Postoperative Pain in Infants
Interventions
Ketorolac Tromethamine 1 mg/kg, Ketorolac Tromethamine 0.5 mg/kg, Placebo
Drug
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
2 Months to 18 Months
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 12, 2013 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Results available

Post Operative Pain Control Using Ropivacaine and the ON-Q System in the Adult Pectus Excavatum Patient

NCT01816477
View directory record Official record
Conditions
Pectus Excavatum
Interventions
ON-Q soaker catheter system, Epidural (ropivicaine 0.25%)
Device · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Sep 17, 2026, 9:36 PM EDT
Recruiting Phase 2Phase 3 Interventional

IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia

NCT06559969
View directory record Official record
Conditions
Laparotomy
Interventions
Intravenous administered opioid, Epidural administered opioid
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Sprix for Postoperative Pain Control Following Gynecologic Surgery

NCT04444830
View directory record Official record
Conditions
Post Operative Pain Control, Narcotic Use, Pelvic Organ Prolapse, Urinary Incontinence , Stress, Surgery
Interventions
Sprix
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Results available

Adductor Canal Block for Total Knee Arthroplasty

NCT02453360
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions
Adductor Canal Block, Adductor Canal Block
Procedure · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Results available

Reducing Post-Op Pain After Sacrospinous Ligament Colpopexy

NCT02037061
View directory record Official record
Conditions
Pain
Interventions
Bupivacaine, Normal Saline
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2019 · Synced Sep 17, 2026, 9:36 PM EDT