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Showing 1–24 of 76 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Post Operative Cognitive Dysfunction Clear all
Active, not recruiting Not applicable Interventional

COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study

NCT04889417
View directory record Official record
Conditions
Cognitive Impairment, Disability Physical, Surgery
Interventions
Comprehensive training program, Active control
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Jul 21, 2026, 12:51 PM EDT
Not listed No phase listed Observational

Cognition and the Immunology of Postoperative Outcomes

NCT04792983
View directory record Official record
Conditions
Cognitive Impairment, Frail Elderly Syndrome, Delirium, Surgery
Interventions
No intervention
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Jul 21, 2026, 12:51 PM EDT
Completed No phase listed Observational

POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

NCT01199913
View directory record Official record
Conditions
1. Postoperative Cognitive Dysfunction
Interventions
The intervention will be Mini-Mental Status Examination (MMSE)
Other
Lead sponsor
Loma Linda University
Other
Eligibility
65 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2014 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction

NCT03802396
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
CN-105, Placebo
Drug
Lead sponsor
Miles Berger, MD PhD
Other
Eligibility
60 Years and older
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Phase 2 Interventional Results available

The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction

NCT02554253
View directory record Official record
Conditions
Cognitive Disorders, Delirium, Acute Kidney Injury
Interventions
Ketamine, Propofol
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
75 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Jul 21, 2026, 12:51 PM EDT
Completed No phase listed Observational

Cognition in Postoperative Total Hip Arthroplasty and Total Hip Resurfacing Patients

NCT01079468
View directory record Official record
Conditions
Cognition
Interventions
Not listed
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 7, 2011 · Synced Jul 21, 2026, 12:51 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Neuroinflammation and Alzheimer's Pathology in POCD

NCT05378659
View directory record Official record
Conditions
Post-Operative Confusion, Neuroinflammatory Response, Alzheimer Disease
Interventions
Montreal Cognitive Assessment, Stroop Test, 4AT Delirium, Grooved Pegboard, NACC Cognitive Battery, ERP Testing, Blood Plasma and Serum sampling, Cerebral Spinal Fluid Sample
Behavioral · Diagnostic Test
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Jul 21, 2026, 12:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients

NCT00417664
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine, Propofol, Midazolam
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 89 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Jul 21, 2026, 12:51 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Improving Surgical Safety of Seniors Through Preoperative Cognitive Screening

NCT02570438
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts • Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Jul 21, 2026, 12:51 PM EDT
Recruiting Not applicable Interventional

Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

NCT07610655
View directory record Official record
Conditions
Post Operative Delirium, Cognitive Impairment, Vagus Nerve Stimulation, Depression
Interventions
Transcutaneous vagal nerve stimulation, Sham (No Treatment)
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Phase 4 Interventional

Donepezil in the Prevention of Post-Operative Cognitive Decline

NCT00182845
View directory record Official record
Conditions
Postoperative Complications, Delirium
Interventions
Donepezil
Drug
Lead sponsor
Pfizer
Industry
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 2, 2008 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Reversal of General Anesthesia With Methylphenidate

NCT02051452
View directory record Official record
Conditions
Post Operative Cognitive Dysfunction, Emergence From Anesthesia
Interventions
Methylphenidate, Saline
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 21, 2019 · Synced Jul 21, 2026, 12:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study To Analyze Memory/Thinking Problems In Older Adults After Surgery

NCT01786577
View directory record Official record
Conditions
Post-Operative Cognitive Decline in Older Adults
Interventions
Magnetic Resonance Imaging, Cognitive assessment testing
Other · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
60 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2019 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reconstructing Consciousness and Cognition

NCT01911195
View directory record Official record
Conditions
Postoperative Cognitive Dysfunction
Interventions
ISOFLURANE- Experimental Arm, Control Group: Cognitive Testing
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
20 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
3
States / cities
Ann Arbor, Michigan • St Louis, Missouri • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Jul 21, 2026, 12:51 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Exploring the Impact of Perioperative Galacto-Oligosaccharides (GOS) on Stress, Anxiety and Cognition

NCT02953691
View directory record Official record
Conditions
Anxiety, Pain, Surgery
Interventions
Galacto-Oligosaccharide, Maltodextrin (Placebo)
Drug
Lead sponsor
Jeff Taekman, M.D.
Other
Eligibility
21 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Phase 2 Interventional Results available

Ramelteon in the Prevention of Post-operative Delirium

NCT02324153
View directory record Official record
Conditions
Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders, Delayed Emergence From Anesthesia, Cognitive Disorders
Interventions
Ramelteon, Microcrystalline Cellulose, Riboflavin 100 mg
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Jul 21, 2026, 12:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stanford ICU Delirium PIPRA Study

NCT06519890
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Delirium, Postoperative
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 8, 2024 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Not applicable Interventional Results available

Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

NCT00788008
View directory record Official record
Conditions
Lumbar Spondylosis, Cervical Spondylosis, Hip Osteoarthritis, Knee Osteoarthritis
Interventions
inhalation anesthesia with isoflurane vs. TIVA with propofol
Drug
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Jul 21, 2026, 12:51 PM EDT
Active, not recruiting Phase 2 Interventional

The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition

NCT03068442
View directory record Official record
Conditions
Cognitive Impairment, Carotid Artery Plaque, Inflammation
Interventions
Imaging with flutemetamol F 18 PET/CT
Drug
Lead sponsor
Scott Mcnally
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2030
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 21, 2026, 12:51 PM EDT
Terminated Not applicable Interventional

Prehabilitation Exercise Plus Perioperative Optimization of Senior Health

NCT03291795
View directory record Official record
Conditions
Cognitive Decline, Age-Related Memory Disorders, Postoperative Complications, Age-Related Atrophy, Postoperative Cognitive Dysfunction
Interventions
Exercise Intervention
Other
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 4, 2019 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Not applicable Interventional

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest

NCT02834065
View directory record Official record
Conditions
Cognition Disorders
Interventions
Cardiopulmonary bypass machine
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
4
States / cities
Atlanta, Georgia • Durham, North Carolina • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Not applicable Interventional

COgnitive and Physical Exercise (COPE) Prehabilitation Pilot Feasibility Study

NCT03094988
View directory record Official record
Conditions
Cognitive Impairment, Physical Impairment, Postoperative Complications
Interventions
Cognitive and physical prehabilitation, Active attention control
Behavioral · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Not applicable Interventional Results available

A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events

NCT00736125
View directory record Official record
Conditions
Postoperative Complications, Memory Disorders
Interventions
pulsatile saline lavage, carbon dioxide lavage
Device
Lead sponsor
Kinamed Incorporated
Industry
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Jul 21, 2026, 12:51 PM EDT
Completed Phase 3 Interventional Results available

Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain

NCT00221338
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Pain, Opioid Use, Hospital Length of Stay
Interventions
Gabapentin
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
65 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Jul 21, 2026, 12:51 PM EDT