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ClinicalTrials.gov public records Last synced Oct 19, 2026, 6:01 PM EDT

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Showing 1–24 of 1,844 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post Operative Pain Clear all
Completed Not applicable Interventional

Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy

NCT03430765
View directory record Official record
Conditions
Persistent Postsurgical Pain, Breast Cancer Female, Ductal Carcinoma in Situ
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Katherine Hadlandsmyth
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain

NCT00667264
View directory record Official record
Conditions
Amputation, Phantom Limb, Stump Pain
Interventions
perineural ropivacaine
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2012 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Not applicable Interventional Results available

Postoperative Subtenons Anesthesia for Postoperative Pain in Pediatric Strabismus Surgery

NCT01812044
View directory record Official record
Conditions
Strabismus
Interventions
subtenons anesthetic - preservative-free bupivacaine 0.75%, topical anesthetic - 0.5 cc of lidocaine 3.5% ophthalmic gel, topical control - 0.5 cc of Hypromellose 0.3% gel, subtenons control - 0.5 cc of Normal Saline
Drug
Lead sponsor
Duke University
Other
Eligibility
1 Year to 7 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2016 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fascial Closure Technique After Gynecologic Laparoscopic Surgery and Postoperative Pain

NCT04765306
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Traditional Direct Fascial Closure, Fascial Closure Device
Device
Lead sponsor
Jessica G Putman
Other
Eligibility
18 Years and older · Female only
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated May 12, 2022 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Not applicable Interventional

Continuous L2 Paravertebral Block Versus Continuous Lumbar Plexus Block for Postoperative Analgesia

NCT01571492
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
L2 Paravertebral catheter nerve block, Continuous Lumbar plexus nerve block
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Oct 19, 2026, 6:01 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Study Evaluating AWBAT-D Versus the Standard of Care of Split-thickness Skin Graft Donor Sites

NCT01252836
View directory record Official record
Conditions
Healing of Donor Site, Pain Level
Interventions
AWBAT-D
Device
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Dec 15, 2016 · Synced Oct 19, 2026, 6:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characterization of PostOp Pain in Shoulder and Knee Arthroscopy

NCT03047434
View directory record Official record
Conditions
Post Surgical Pain
Interventions
Not listed
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

Intravenous Acetaminophen for Non-Narcotic Postoperative Pain Management Following Knee Arthroscopy

NCT02025634
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Intravenous Acetaminophen, Placebo (0.9% Normal Saline infusion)
Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years to 89 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Celebration, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2020 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 3 Interventional Results available

Maxigesic IV Phase 3 Bunionectomy Study

NCT02689063
View directory record Official record
Conditions
Post Operative Pain
Interventions
Maxigesic IV, IV Acetaminophen, IV Ibuprofen, Placebo IV
Drug
Lead sponsor
AFT Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years to 65 Years
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Pasadena, Maryland • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

AbsorbaTack Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair

NCT00749268
View directory record Official record
Conditions
Hernia, Inguinal, Hernia, Ventral
Interventions
AbsorbaTack, ProTack
Device
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years and older
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Cleveland, Ohio • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 2 Interventional Results available

Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)

NCT04630158
View directory record Official record
Conditions
Chronic Ocular Pain
Interventions
SAF312 Placebo, SAF312
Other · Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
24
States / cities
Mission Hills, California • Newport Beach, California • Palo Alto, California + 19 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy

NCT05121168
View directory record Official record
Conditions
Pain, Acute Postoperative, Renal Stone
Interventions
Active bupivacaine 0.25% via an erector spinae plane perineural catheter, Placebo normal saline via an erector spinae plane perineural catheter
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 2 Interventional Results available

Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study

NCT03879408
View directory record Official record
Conditions
Pain
Interventions
440 mg naproxen sodium with 1000 mg acetaminophen, 220 mg naproxen sodium with 650 mg acetaminophen, 10 mg hydrocodone + 650 mg acetaminophen, 440 mg naproxen sodium, Placebo tablet
Drug
Lead sponsor
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Industry
Eligibility
17 Years to 50 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 5, 2022 · Synced Oct 19, 2026, 6:01 PM EDT
Terminated Phase 4 Interventional Results available

Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients

NCT03638635
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative, Colectomy, Colorectal Surgery
Interventions
Bupivacaine, Bupivacaine liposome
Drug
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
6
States / cities
Alexandria, Virginia • Fairfax, Virginia • Falls Church, Virginia + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

Opioid Free Management After Ureteroscopy

NCT03872843
View directory record Official record
Conditions
Kidney Stone
Interventions
Norco 5milligram-325milligram Tablet, Ibuprofen 400 MILLIGRAM in 1 TABLET ORAL TABLET, FILM COATED
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Oct 19, 2026, 6:01 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Ropivacaine Transversus Abdominis Plane Blocks for Cesarean Section Analgesia

NCT02893423
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ropivacaine
Drug
Lead sponsor
Maimonides Medical Center
Other
Eligibility
Female only
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 19, 2026, 6:01 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Medrol Dosepak for Outpatient Total Knee Arthroplasty

NCT05097976
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Methylprednisolone, Placebo
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Oak Brook, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Phase 4 Interventional Results available

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty

NCT02713490
View directory record Official record
Conditions
Pain
Interventions
EXPAREL, Bupivacaine
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older · Male only
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
17
States / cities
Fremont, California • Loma Linda, California • Fort Lauderdale, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2020 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study to Compare Suture Material in Closure of Uterine Incision in Cesarian Section

NCT02517710
View directory record Official record
Conditions
Hysterotomy Closure
Interventions
Stratafix synthetic barbed suture
Procedure
Lead sponsor
Evangelical Community Hospital, Lewisburg, PA
Other
Eligibility
16 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Lewisburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 10, 2018 · Synced Oct 19, 2026, 6:01 PM EDT
Not listed Phase 1Phase 2 Interventional

Postoperative Pain Control With Lipossomic Extended Release Bupivacaine

NCT03560362
View directory record Official record
Conditions
Pain, Postoperative, Lung Cancer
Interventions
Bupivacaine liposome, Bupivacaine / Epinephrine
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Oct 19, 2026, 6:01 PM EDT
Completed Not applicable Interventional Results available

A Dose Ranging Effect of Preoperative Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Surgery

NCT01451762
View directory record Official record
Conditions
Surgery, Pain
Interventions
.9 normal saline, 25 mg diphenhydramine IV, 50 mg diphenhydramine IV
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 14, 2014 · Synced Oct 19, 2026, 6:01 PM EDT
Terminated Phase 4 Interventional

Prevention of Phantom Limb and Stump Pain Using Ambulatory Continuous Peripheral Nerve Blocks: A Pilot Study

NCT00771862
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Stump Pain
Interventions
perineural ropivicaine
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Oct 19, 2026, 6:01 PM EDT
Recruiting Not applicable Interventional

Imagined Acupuncture for Postoperative Pain After Spinal Surgery

NCT07197710
View directory record Official record
Conditions
Pain Management
Interventions
video-guided acupuncture imagery treatment (VGAIT), Education video
Other
Lead sponsor
Jingping Wang, MD, Ph.D.
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 19, 2026, 6:01 PM EDT
Completed No phase listed Observational

BRS and Outcomes in Cardiothoracic Surgery

NCT03243279
View directory record Official record
Conditions
Pain, Postoperative, Atrial Fibrillation, Cognitive Dysfunction
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Oct 19, 2026, 6:01 PM EDT