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ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 586 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Post Operative Pain Control Clear all

Conditions: Pain, Postoperative
Interventions: PMI-150 (intranasal ketamine), Placebo; Drug
Lead sponsor: Hospira, now a wholly owned subsidiary of Pfizer; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 16
States / cities: Birmingham, Alabama • Florence, Alabama • Sheffield, Alabama + 13 more

Conditions: Post Operative Pain
Interventions: Morphine; Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 3 Years to 18 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Detroit, Michigan • Salt Lake City, Utah

Conditions: Acute, Post-operative Pain
Interventions: ST-2427, Placebo; Drug
Lead sponsor: SiteOne Therapeutics, Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Post-Operative Pain, Chronic
Interventions: Adductor Canal Block, Intra-articular Injection; Drug
Lead sponsor: Loyola University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Lumbar Spine Surgery
Interventions: DepoDur; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Pain, Pain, Postoperative
Interventions: cryoSPHERE Ablation, Bupivacaine; Device · Drug
Lead sponsor: The Methodist Hospital Research Institute; Other
Eligibility: 18 Years to 90 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Carpal Tunnel
Interventions: Narcotic, non-narcotic; Drug
Lead sponsor: Horizon Health Network; Other
Eligibility: 18 Years to 90 Years
Enrollment: 347 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 3
States / cities: Philadelphia, Pennsylvania • Sioux Falls, South Dakota • Roanoke, Virginia

Conditions: Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
Interventions: Liposomal bupivacaine, Bupivacaine; Drug
Lead sponsor: Northern Light Mercy Hospital; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Portland, Maine

Conditions: Pain, Post-operative
Interventions: Ropivacaine 0.35%; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Post Operative Pain
Interventions: Oxycodone, Tramadol and Oxycodone; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 560 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Pain
Interventions: Acetaminophen, Placebo; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Umbilical Hernia, Obesity
Interventions: TAPB Group, RSB Group, conversion to general anesthesia; Procedure
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 99 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Post Operative Pain
Interventions: Liposomal bupivacaine, 0.5% bupivacaine with 1:100,000 epinephrine; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years and older
Enrollment: 85 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Congenital Heart Disease in Children
Interventions: Continuous ketorolac; Drug
Lead sponsor: Phoenix Children's Hospital; Other
Eligibility: 3 Months to 59 Months
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Post Operative Pain
Interventions: Methadone Hydrochloride; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 75 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Postoperative Pain
Interventions: Bupivacaine; Drug
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: Up to 8 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Lumbar Spinal Fusion
Interventions: Ketorolac Tromethamine, Placebo; Drug
Lead sponsor: University of Maryland St. Joseph Medical Center; Other
Eligibility: 18 Years to 85 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Towson, Maryland

Conditions: Analgesia, Post-Operative Pain, Breakthrough Pain, Colectomy
Interventions: Non-Narcotic ERAS Post-Operative Pain Management; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Tonsillitis, Obstructive Sleep Apnea of Child
Interventions: Dexamethasone, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 3 Years to 12 Years
Enrollment: 163 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Osteoarthritis, Osteoarthritis, Knee, Arthritis, Degenerative, Osteoarthrosis, Osteoarthrosis Deformans
Interventions: Bupivacaine Liposome Injection, Indwelling femoral nerve block; Drug
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: San Diego, California

Conditions: Shoulder Pain
Interventions: Active lavage and suction; Procedure
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 4
States / cities: Chattanooga, Tennessee

Conditions: Anesthesia
Interventions: Continuous Adductor Canal Catheter (ACC), Adductor Canal block with sham catheter; Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 65 Years
Enrollment: 94 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Spine Fusion, Lumbar Spine Degeneration, Pain, Postoperative, Lumbar Spine Spondylosis
Interventions: Zolpidem Tartrate 10 mg, Placebo; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years to 75 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2030
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Liposomal Bupivacaine
Interventions: Bupivacaine liposome injectable suspension; Drug
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Cleveland, Ohio

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Safety and Efficacy of Repeated Doses of PMI-150 (Intranasal Ketamine) in Acute Post-operative Pain Following Orthopedic Surgery

Morphine PK Subgroup Analysis

Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ST-2427

Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery

Safety and Efficacy of DepoDur in Lumbar Spine Surgery Patients

Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients

Narcotic vs. Non-narcotic Pain Study Protocol

Trial of Liposomal Bupivacaine for TKA

Serratus Anterior Plane Block in Patients Undergoing Mastectomy

Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty

The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy

Abdominal Wall Block Study

Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions

Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery

Methadone in TKA for Post-op Pain and Opioid Reduction

Transversus Abdominis Plane Blocks for Infants and Children for Postoperative Pain Control

Ketorolac Effects on Post-operative Pain and Lumbar Fusion

A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy

Steroids and Pain Control After Tonsillectomy

Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty

Lavage and Suction of the Right Upper Quadrant to Reduce Post Laparoscopic Shoulder Pain

Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

Exparel Versus Bupivacaine in Post-operative Pain Control