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Showing 1–24 of 210 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Post Operative Surgical Site Infection Clear all
Recruiting Phase 1 Interventional

A Study of Amicidin-β Topical Solution for Patients With Surgical or Traumatic Wound Infections

NCT07379684
View directory record Official record
Conditions
Surgical Wound Infection, Traumatic Wound Infection
Interventions
Amicidin-β topical solution - 15 mL, Amicidin-β topical solution - 50 mL, Standard of Care (SOC)
Drug
Lead sponsor
Macro Biologics, Inc.
Industry
Eligibility
18 Years to 79 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
5
States / cities
Torrance, California • Idaho Falls, Idaho • Baltimore, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 11, 2026, 10:26 PM EDT
Terminated Not applicable Interventional Results available

Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial

NCT00386477
View directory record Official record
Conditions
Cesarean Section, Endometritis, Surgical Wound Infection
Interventions
Vaginal cleansing before cesarean delivery
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
3
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 7, 2010 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections

NCT01431339
View directory record Official record
Conditions
Abscess, Wound Infection, Surgical Site Infection, Cellulitis
Interventions
IV Dalbavancin, Vancomycin/Linezolid
Drug
Lead sponsor
Durata Therapeutics Inc., an affiliate of Allergan plc
Industry
Eligibility
18 Years to 85 Years
Enrollment
739 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
30
States / cities
Montgomery, Alabama • Anaheim, California • Buena Park, California + 26 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2014 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Chlorhexidine-Alcohol Versus Povidone-Iodine for Cesarean Antisepsis

NCT02202577
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Chlorhexidine - Isopropyl alcohol, Povidone-Iodine Scrub and Paint
Drug
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
932 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Phase 2Phase 3 Interventional Results available

NPWT in Patients Undergoing Surgical Procedures for Management of GI Malignancies

NCT04955730
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Negative Pressure Wound Therapy
Device
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Phase 3 Interventional

Local Warming of Surgical Incisions

NCT01026259
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Warming of surgical incision, Warming dressing without actual warming
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 3, 2009 · Synced Sep 11, 2026, 10:26 PM EDT
Terminated Phase 4 Interventional

Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens

NCT03560232
View directory record Official record
Conditions
Open Fracture, Post-Op Wound Infection
Interventions
Ceftriaxone, Ampicillin/sulbactam, Piperacillin/tazobactam, Cefazolin + Gentamicin, Clindamycin + Gentamicin
Drug
Lead sponsor
Mercy Health Ohio
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Warren, Ohio • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 10, 2020 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

Air Barrier System for the Prevention of Surgical Site Infection

NCT01610271
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Air Barrier System
Device
Lead sponsor
Nimbic Systems, LLC
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 2, 2019 · Synced Sep 11, 2026, 10:26 PM EDT
Not listed Phase 4 Interventional

Study on the Reapplication of Chloraprep After Lower Extremity Surgery and Prior to Dressing Application

NCT02017145
View directory record Official record
Conditions
Lower Extremity Surgery, Surgical Site Infection, Bacterial Colonization, Surgical Antiseptic
Interventions
Chloraprep
Drug
Lead sponsor
Sanford Health
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Feb 18, 2014 · Synced Sep 11, 2026, 10:26 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Zonulin Biomarker for Diagnosis of Hip and Knee Infections

NCT04666519
View directory record Official record
Conditions
Surgical Site Infection, Zonulin
Interventions
Zonulin Biomarker
Diagnostic Test
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 13, 2020 · Synced Sep 11, 2026, 10:26 PM EDT
Not listed No phase listed Observational

Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds

NCT03872544
View directory record Official record
Conditions
Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection, Wound Complication, Wound Dehiscence, Wound of Skin, Wound Open, Wounds, Penetrating, Wounds, Nonpenetrating, Wounds and Injuries, Wounds, Disturbance of Wound Healing, Facial Bones Fracture, Soft Tissue Injuries, Skull Fractures, Surgical Wound, Surgical Wound Infection, Wound Healing
Interventions
Not listed
Lead sponsor
Dufresne, Craig, MD, PC
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Sep 11, 2026, 10:26 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Analysis of the Incidence of Post-Operative Wound Infections After Spine Surgery

NCT02891486
View directory record Official record
Conditions
Infection
Interventions
Spinal surgery
Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 99 Years
Enrollment
6,959 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Sep 11, 2026, 10:26 PM EDT
Recruiting Phase 3 Interventional

Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2

NCT04678154
View directory record Official record
Conditions
Post Operative Surgical Site Infection
Interventions
Standard of care, Vancomycin and Tobramycin
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 64 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
31
States / cities
Redwood City, California • San Francisco, California • Aurora, Colorado + 25 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 11, 2026, 10:26 PM EDT
Active, not recruiting No phase listed Observational

Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

NCT04773457
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Surgical Site Infection
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Months to 19 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

PICO Negative Pressure Wound Therapy in Obese Women Undergoing Elective Cesarean Delivery.

NCT03414762
View directory record Official record
Conditions
Cesarean Section Complications, Cesarean Wound; Dehiscence, Cesarean Wound Disruption
Interventions
PICO Negative Pressure Wound Therapy, Standard Dressing
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Sep 11, 2026, 10:26 PM EDT
Terminated Not applicable Interventional

AO Multicenter Intervention Trial for Prevention of Surgical Site Infection

NCT03380273
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Implementation of the AO Trauma SSI Prevention Bundle
Behavioral
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
18 Years to 100 Years
Enrollment
222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
8
States / cities
Los Angeles, California • Lexington, Kentucky • Worcester, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2022 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity

NCT00603603
View directory record Official record
Conditions
Infection; Cesarean Section, Surgical Wound Infection, Endometritis
Interventions
80% inhaled oxygen via non-rebreather mask, 30% inhaled oxygen via nasal cannula
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 50 Years · Female only
Enrollment
606 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 21, 2016 · Synced Sep 11, 2026, 10:26 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery

NCT02799667
View directory record Official record
Conditions
Obesity, Surgical Site Infections, Wound Complications, Complications; Cesarean Section
Interventions
Standard Dressing, Negative Pressure Wound Therapy Dressing
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Perioperative Patient Skin Antiseptic Preparation Evaluation

NCT04756804
View directory record Official record
Conditions
Surgical Site Infection
Interventions
70% v/v Isopropyl Alcohol Surgical Solution, 2%w/v Chlorhexidine Gluconate / 70% v/v Isopropyl Alcohol
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Sep 11, 2026, 10:26 PM EDT
Terminated Not applicable Interventional Results available

Vaginal Prep Solutions to Reduce Bacteria Colony Counts in Patients Having a Vaginal Surgery

NCT03854370
View directory record Official record
Conditions
Surgical Site Infection, Vaginal Surgery
Interventions
Baby shampoo, Betadine, Peridex, TechniCare
Other
Lead sponsor
Wright State University
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate Efficacy and Safety of E-101 Solution for Preventing Surgical Site Infections After Colorectal Surgery

NCT01297959
View directory record Official record
Conditions
Infections
Interventions
E-101 Solution 300 GU/ml, Saline solution
Drug
Lead sponsor
Excited States, LLC
Industry
Eligibility
18 Years and older
Enrollment
503 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
34
States / cities
Mobile, Alabama • Los Angeles, California • Stanford, California + 29 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2021 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

The Value of Home Chlorhexidine Pre-Surgical Wash Before Spine Surgery

NCT02767427
View directory record Official record
Conditions
Infection, Spinal Injuries
Interventions
Chlorhexidine Wipes, No intervention
Device · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 5, 2023 · Synced Sep 11, 2026, 10:26 PM EDT
Active, not recruiting Phase 1 Interventional

Precision Antibiotic Dosing for Appendectomy

NCT06860802
View directory record Official record
Conditions
Appendicitis (Diagnosis)
Interventions
Cefoxitin
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 11, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children

NCT04366440
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Order set review and modification with facilitation, Order set review and modification
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
0 Days to 75 Years
Enrollment
18,267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
10
States / cities
St. Petersburg, Florida • Boston, Massachusetts • Ann Arbor, Michigan + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 11, 2026, 10:26 PM EDT