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ClinicalTrials.gov public records Last synced Oct 21, 2026, 9:24 AM EDT

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Showing 217–240 of 247 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post Partum Depression Clear all
Not yet recruiting Not applicable Interventional

Pilot Feasibility Study With Doulas

NCT07614789
View directory record Official record
Conditions
Post Partum, Maternal Depression, Maternal Depression and Parent Practices, Postpartum
Interventions
YouMatter
Behavioral
Lead sponsor
Duke University
Other
Eligibility
Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 21, 2026, 9:24 AM EDT
Recruiting Not applicable Interventional

Accelerated TMS for Perinatal Depression

NCT06968390
View directory record Official record
Conditions
Perinatal Depression, Post Partum Depression, Major Depressive Disorder
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Pivotal Test: WB001

NCT04576754
View directory record Official record
Conditions
Postpartum Depression
Interventions
WB001, Educational
Device
Lead sponsor
Woebot Health
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 21, 2026, 9:24 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Curio Digital Therapy for the Treatment of Post-partum Depression

NCT05958095
View directory record Official record
Conditions
PostPartum Depression
Interventions
MamaLift Plus, Digital Sham App
Device
Lead sponsor
Healthcare Innovation Technology Lab
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 21, 2026, 9:24 AM EDT
Completed No phase listed Observational Results available

Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic

NCT04385238
View directory record Official record
Conditions
COVID-19, Pregnancy Complications, Mental Health Wellness 1, Anxiety, Depression, Ptsd, Coronavirus
Interventions
This is an online survey with no intervention.
Other
Lead sponsor
Pregistry
Industry
Eligibility
18 Years and older · Female only
Enrollment
6,894 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2021 · Synced Oct 21, 2026, 9:24 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Mobile Application in the Management of Mild to Moderate Postpartum Depression (PPD)

NCT05077644
View directory record Official record
Conditions
Post-partum Depression
Interventions
Stella (TM) Mobile Application
Device
Lead sponsor
Curio Digital Therapeutics, Inc.
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lactation Achievement With Texts at Home

NCT04108533
View directory record Official record
Conditions
Breastfeeding, Breastfeeding, Exclusive, Postpartum Depression
Interventions
Text-Based Support
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 2, 2021 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Case Management Study for Postpartum Depression and Intimate Partner Violence

NCT00560027
View directory record Official record
Conditions
Postpartum Depression, Intimate Partner Violence
Interventions
Case Management by Family Support Counselor (not RCT)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Female only
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Effect of Exercise on Preventing PostPartum Depression

NCT00961402
View directory record Official record
Conditions
PostPartum Depression
Interventions
Wellness Control, Exercise Intervention
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older · Female only
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Oct 21, 2026, 9:24 AM EDT
Terminated No phase listed Observational

A Prospective Study of Postpartum Depression in Women With Major Depression

NCT01328613
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years and older · Female only
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Phase 4 Interventional Results available

Escitalopram (Lexapro) for the Treatment of Postpartum Depression

NCT00833469
View directory record Official record
Conditions
Postpartum Depression
Interventions
Escitalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2014 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Phase 4 Interventional Results available

Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries

NCT03470675
View directory record Official record
Conditions
Pain, Postpartum Depression
Interventions
Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Efficacy of Brief Acceptance and Commitment Therapy (ACT) for Perinatal Anxiety

NCT03837392
View directory record Official record
Conditions
Post Partum Depression, Perinatal Depression, Post Partum Anxiety, Perinatal Anxiety
Interventions
Baseline Assessment (18-26 weeks pregnant), Online Intervention and Phone Coaching Interventions, Follow Up Assessments: 34-36 weeks pregnant and 4-week postpartum, Follow Up Assessments: 8 weeks postpartum
Diagnostic Test · Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Oct 21, 2026, 9:24 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

A Study of a Test for Postpartum Depression at Home

NCT07186309
View directory record Official record
Conditions
Postpartum Depression (PPD), Pregnancy
Interventions
Diagnostic Test: Enlighten
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Female only
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 21, 2026, 9:24 AM EDT
Terminated Phase 2 Interventional Results available

Clinical Trial of Estrogen for Postpartum Depression

NCT00059228
View directory record Official record
Conditions
Postpartum Depression, Depression
Interventions
17beta Estradiol, Placebos
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
20 Years to 45 Years · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Maternal Depression and Promoting Infant Social-Emotional Health & Development

NCT03464630
View directory record Official record
Conditions
Maternal Depression and Parent Practices, Postpartum, Infant Development
Interventions
Mom & Baby Net, Depression & Developmental Awareness System
Behavioral
Lead sponsor
Georgia State University
Other
Eligibility
18 Years and older · Female only
Enrollment
368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Personality Style and Self Compassion in Postpartum Depression: An Online Prevention Study

NCT02813174
View directory record Official record
Conditions
Postpartum Depression
Interventions
Compassionate Mind Training from Compassion-Focused Therapy
Behavioral
Lead sponsor
i4Health
Other
Eligibility
18 Years and older · Female only
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cradling Our Future Through Family Strengthening Study

NCT00373750
View directory record Official record
Conditions
Substance Abuse, Post-partum Depression, Depression
Interventions
Family Spirit Intervention
Procedure
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
12 Years to 19 Years · Female only
Enrollment
322 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
5
States / cities
Fort Defiance, Arizona • San Carlos, Arizona • Tuba City, Arizona + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2015 · Synced Oct 21, 2026, 9:24 AM EDT
Terminated Phase 2 Interventional Results available

Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression

NCT04011592
View directory record Official record
Conditions
Post Partum Depression
Interventions
Ketamine 0.5 mg/kg, Ketamine 0.2 mg/kg
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Sertraline for the Prevention of Recurrent Postpartum Depression

NCT00276900
View directory record Official record
Conditions
Depression
Interventions
Sertraline
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2013 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers

NCT00436150
View directory record Official record
Conditions
Depression
Interventions
Interpersonal therapy-based treatment, Standard care
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 12, 2013 · Synced Oct 21, 2026, 9:24 AM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD)

NCT04442503
View directory record Official record
Conditions
Depression, Postpartum
Interventions
SAGE-217, Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
68
States / cities
Scottsdale, Arizona • Bentonville, Arkansas • Anaheim, California + 62 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 21, 2026, 9:24 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Maternal Mental Health Access - MaMa

NCT06049433
View directory record Official record
Conditions
Postpartum Depression, Perinatal Depression
Interventions
Maternal Mental Health Access for Postpartum Depression- Prevention and UPLIFT- intervention, On-Demand + Discussion board (DB), Arm 2, On Demand (OD) + Video Conference (VC), Arm 3
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 21, 2026, 9:24 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Preventing Postpartum Depression in Immigrant Latinas

NCT05873569
View directory record Official record
Conditions
Postpartum Depression
Interventions
Mothers and Babies Virtual Group Intervention
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 21, 2026, 9:24 AM EDT