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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:03 PM EDT

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Showing 49–72 of 247 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post Partum Depression Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Meditation for NICU Moms

NCT03574766
View directory record Official record
Conditions
Breast Feeding, Premature Birth, Stress, Depression, Postpartum, Anxiety, Self Efficacy, Behavior, Maternal, Insufficient Lactation
Interventions
Meditation
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Richmond Heights, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 20, 2026, 4:03 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression?

NCT02272387
View directory record Official record
Conditions
Depression, Postpartum Depression
Interventions
Vitamin D3 (Cholecalciferol), Placebo
Dietary Supplement · Other
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years and older · Female only
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 24, 2017 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression

NCT00602355
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Sertraline, Placebo, Interpersonal psychotherapy (IPT), Clinical management, Mothercrafting
Drug · Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
2
States / cities
Iowa City, Iowa • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 21, 2016 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional

Intervention for IPV-exposed Pregnant Women

NCT04068662
View directory record Official record
Conditions
Postpartum Depression, Posttraumatic Stress Disorder, Infant Behavior, Violence, Parenting
Interventions
Pregnant Moms' Empowerment Program, Nondirective Support Group
Behavioral
Lead sponsor
University of Notre Dame
Other
Eligibility
3 Months to 55 Years · Female only
Enrollment
424 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Notre Dame, Indiana • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 20, 2026, 4:03 PM EDT
Terminated No phase listed Observational

A Prospective Study of Postpartum Depression in Women With Major Depression

NCT01328613
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years and older · Female only
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 20, 2026, 4:03 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postpartum Depression and Cesarean Section

NCT00370903
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
15 Years to 43 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 4, 2008 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD)

NCT04442503
View directory record Official record
Conditions
Depression, Postpartum
Interventions
SAGE-217, Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
68
States / cities
Scottsdale, Arizona • Bentonville, Arkansas • Anaheim, California + 62 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional Results available

Personalized Integrated Chronotherapy for Perinatal Depression

NCT04364646
View directory record Official record
Conditions
Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation, Pregnancy Related, Sleep Disturbance
Interventions
Personalized Integrated Chronotherapy
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Glen Oaks, New York • Chapel Hill, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effectiveness of Supplemental Calcium in Preventing Postpartum Depression

NCT00228033
View directory record Official record
Conditions
Depression, Depression, Postpartum
Interventions
Elemental calcium (as carbonate)
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older · Female only
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 20, 2014 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional

Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)

NCT05356364
View directory record Official record
Conditions
Insomnia, Depression
Interventions
Cognitive Behavioral Therapy for Insomnia (CBTI), Perinatal Understanding of Mindful Awareness for Sleep (PUMAS)
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression

NCT02978326
View directory record Official record
Conditions
Postpartum Depression
Interventions
SAGE-217 15/20 mg Oral Solution, Placebo, SAGE 217 30 mg Capsules
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
27
States / cities
Little Rock, Arkansas • Beverly Hills, California • Oceanside, California + 24 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2023 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional

MomMoodBooster VA Program

NCT05196152
View directory record Official record
Conditions
Perinatal Depression, Postpartum Depression
Interventions
MomMoodBooster, Phone Coaching
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 20, 2026, 4:03 PM EDT
Recruiting Phase 3 Interventional

Brexanolone Lifting Outcomes Of Moms

NCT07822321
View directory record Official record
Conditions
Depression, Postpartum, Postpartum Depression (PPD), Post-partum Depression, Postnatal Depression, Post-Natal Depression, Peripartum Depression
Interventions
LPCN 1154A, Placebo
Drug
Lead sponsor
Lipocine Inc.
Industry
Eligibility
15 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
16
States / cities
Tucson, Arizona • Canoga Park, California • Walnut Creek, California + 13 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 20, 2026, 4:03 PM EDT
Recruiting Not applicable Interventional

Engage & Connect: A Psychotherapy for Postpartum Depression

NCT05585164
View directory record Official record
Conditions
Postpartum Depression
Interventions
Engage & Connect (E&C), Symptom Review and Psychoeducation (SRP)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 20, 2026, 4:03 PM EDT
Recruiting Not applicable Interventional

In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression

NCT05766475
View directory record Official record
Conditions
Postpartum Depression
Interventions
ROSE Program: In Person, ROSE Program: Virtual
Behavioral
Lead sponsor
University of Denver
Other
Eligibility
18 Years and older · Female only
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional Results available

Postpartum Wellness

NCT04414696
View directory record Official record
Conditions
Postpartum Depression
Interventions
Exercise intervention
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication

NCT06053515
View directory record Official record
Conditions
Pregnancy, Postpartum Depression, Infant Development, Infant Conditions
Interventions
Rosie the Chatbot
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
14 Years to 99 Years · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 20, 2026, 4:03 PM EDT
Terminated Not applicable Interventional Results available

Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression

NCT02235064
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Sertraline, Placebo
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional

Efficacy of Yoga for Postpartum Depression

NCT02213601
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Yoga
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Phase 2 Interventional Results available

Preventing Postpartum Depression With Intranasal Oxytocin

NCT02505984
View directory record Official record
Conditions
Depression, Postpartum, Anxiety
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrating Text Messages Into the Mothers and Babies Course

NCT03420755
View directory record Official record
Conditions
Perinatal Depression, Postpartum Depression
Interventions
Mothers and Babies 1-on-1, Mothers and Babies Plus Text
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older · Female only
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women

NCT04285684
View directory record Official record
Conditions
Ketamine, Lactation
Interventions
ketamine in lactation
Drug
Lead sponsor
The Ketamine Research Foundation
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Anselmo, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Oct 20, 2026, 4:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Web-based Prevention Program for Postpartum Depression

NCT00816725
View directory record Official record
Conditions
Depression, Postpartum Depression
Interventions
Mothers and babies Internet course and PPD informational brochure
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 11, 2014 · Synced Oct 20, 2026, 4:03 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of CES in New Mothers During the Post Partum Period

NCT03210155
View directory record Official record
Conditions
Anxiety, Depression, Insomnia, Sleep Quality
Interventions
Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator)
Device
Lead sponsor
Christina Murphey, RN, PhD
Individual
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Austin, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Oct 20, 2026, 4:03 PM EDT