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Showing 1–24 of 116 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Post-Concussion Symptoms Clear all
Terminated No phase listed Observational Accepts healthy volunteers

Cerebral Blood Flow Regulation and Concussions

NCT02754206
View directory record Official record
Conditions
Brain Concussion, Post-Concussion Syndrome
Interventions
Not listed
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years to 30 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 13, 2021 · Synced Jul 21, 2026, 11:24 AM EDT
Active, not recruiting Not applicable Interventional

Brain Stimulation for Concussion

NCT05889117
View directory record Official record
Conditions
Transcranial Magnetic Stimulation, Magnetic Resonance Imaging, Neuropsychological Tests, Traumatic Brain Injury, Post-Concussion Syndrome
Interventions
Intermittent theta-burst treatment (iTBS) using MagPro Transcranial Magnetic Stimulator (manufacturer: Magventure)
Device
Lead sponsor
The Mind Research Network
Other
Eligibility
18 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Jul 21, 2026, 11:24 AM EDT
Recruiting Not applicable Interventional

Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)

NCT06413173
View directory record Official record
Conditions
Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment, Post Concussive Symptoms
Interventions
Active tDCS and Cognitive Training Intervention, Sham tDCS and Cognitive Training Intervention
Combination Product
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 60 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
San Diego, California • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

NCT02266329
View directory record Official record
Conditions
Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache, Mild Traumatic Brain Injury, Posttraumatic Migraine
Interventions
prazosin hydrochloride, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Bright Light Therapy in Mild Traumatic Brain Injury

NCT01747811
View directory record Official record
Conditions
Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
Interventions
wavelength-1 bright light, wavelength-2 bright light
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Jul 21, 2026, 11:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Craniosacral Therapy for Concussion Symptoms

NCT04820192
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
Craniosacral Therapy
Other
Lead sponsor
Special Therapies, Inc.
Other
Eligibility
14 Years to 90 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Waukesha, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 28, 2021 · Synced Jul 21, 2026, 11:24 AM EDT
Active, not recruiting No phase listed Observational

Utilizing Electronic Clinical Decision Support to Enhance mTBI Care at the Primary Care Point of Entry

NCT06693778
View directory record Official record
Conditions
Brain Concussion, Mild Traumatic Brain Injury
Interventions
electronic Clinical Decision Support tool for risk stratification of pediatric patients with mTBI
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
5 Years to 18 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Phase 2 Interventional

Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)

NCT01220713
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Interventions
Hyperbaric Oxygen Therapy
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
19 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Portsmouth, Virginia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2013 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional

Feasibility Testing of Cognitive Strategy Training in Post-Concussive Syndrome

NCT04681742
View directory record Official record
Conditions
Brain Concussion, Post-Concussion Syndrome
Interventions
CO-OP Group
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Phase 2 Interventional

Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury

NCT01986205
View directory record Official record
Conditions
Brain Injury, Chronic
Interventions
Hyperbaric Oxygen, Minimal pressure air
Combination Product
Lead sponsor
Lindell Weaver
Other
Eligibility
18 Years to 70 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Murray, Utah • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Jul 21, 2026, 11:24 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Pediatric Concussion Outcomes

NCT04226365
View directory record Official record
Conditions
Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
Interventions
Nortriptyline, Placebo
Drug
Lead sponsor
Lancaster General Hospital
Other
Eligibility
13 Years to 21 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional Results available

Neurofeedback Impact on Veterans With mTBI

NCT04195685
View directory record Official record
Conditions
Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache, Chronic Insomnia, Chronic Attention Disorder
Interventions
Neurofeedback (NFB)
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 21, 2026, 11:24 AM EDT
Recruiting Phase 2Phase 3 Interventional

Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms

NCT07071350
View directory record Official record
Conditions
Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder, Persistent Post Concussion Syndrome
Interventions
HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI), Quantitative Sleep Measures, Patient Global Impression of Change (PGIC), Cognitive Performance/NIH Toolbox Cognitive Battery, Pain Interference/TBI-QoL Pain Interference Short-Form, Patient Health Questionnaire-9 (PHQ-9), PTSD Checklist for DSM-5 (PCL-5), HRV Biofeedback (HRV-B), Psychoeducational (Edu) Comparator Intervention
Other · Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional

Concussion Symptom Treatment and Education Program (C-STEP) in Post-Concussion Syndrome

NCT04111991
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
Usual Care, C-STEP (Cognitive Behavioral Therapy)
Behavioral
Lead sponsor
Sean Rose
Other
Eligibility
10 Years to 18 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional

Art Therapy QEEG Study for Service Members with a Traumatic Brain Injury and Posttraumatic Stress Symptoms

NCT04776304
View directory record Official record
Conditions
Post-Traumatic Headache, PTSD, TBI, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Stress Disorder, Delayed Onset, Sleep Disturbance, Nightmare, Nightmares, REM-Sleep Type, Headache, Irritable Mood, Anger, Eating Disorders, Combat and Operational Stress Reaction, Combat Stress Disorders, Military Operations, Military Activity, Military Family
Interventions
Art Therapy
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Jul 21, 2026, 11:24 AM EDT
Not listed Not applicable Interventional

A Wrist-Worn Nerve Stimulator for Remediating Persistent Post-Concussive Symptoms in Adolescents

NCT05685121
View directory record Official record
Conditions
Concussion, Brain
Interventions
Apollo Neuro
Device
Lead sponsor
University of South Carolina
Other
Eligibility
10 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional

Biopsychosocial Effect of Service Dog Training on Post-traumatic Stress (PTS) and Post Concussive Symptoms

NCT03907254
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Posttraumatic Stress Disorder, Traumatic Brain Injury
Interventions
Service Dog Training Program
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jul 21, 2026, 11:24 AM EDT
Recruiting Not applicable Interventional

Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

NCT05682677
View directory record Official record
Conditions
Depression, Mild Traumatic Brain Injury, Concussion, Brain
Interventions
iTBS, sham iTBS, Personalized, Augmented Cognitive Training (PACT)
Device · Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional Results available

Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBI

NCT02057081
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Posttraumatic Stress Disorders, Depression
Interventions
Multifamily Group for mTBI for Couples, Group Health Education (GHE)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
3
States / cities
Baltimore, Maryland • New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Jul 21, 2026, 11:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)

NCT01334528
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post-Concussive Symptoms
Interventions
Not listed
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 45 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Jul 21, 2026, 11:24 AM EDT
Withdrawn Not applicable Interventional

Assessing the Effects of a Clinical Exercise Protocol on Children With Post-concussion Syndrome

NCT02459145
View directory record Official record
Conditions
Post Concussion Syndrome
Interventions
Graduated exercise protocol
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
13 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Jul 21, 2026, 11:24 AM EDT
Terminated No phase listed Observational

Hyperbaric Oxygen Therapy in Chronic Traumatic Brain Injury or Post-Traumatic Stress Disorder

NCT01105962
View directory record Official record
Conditions
Traumatic Brain Injury, Post-traumatic Stress Disorder
Interventions
Not listed
Lead sponsor
International Hyperbaric Medical Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
10
States / cities
San Francisco, California • Boulder, Colorado • Delray Beach, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2016 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Not applicable Interventional

Comparing the Effect of Osteopathic Manipulative Medicine (OMM) Versus Counseling in the Treatment of Concussion

NCT02750566
View directory record Official record
Conditions
Post-Concussion Symptoms, Distorted; Balance
Interventions
Osteopathic Manipulative Treatment, Counseling
Procedure · Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years to 50 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Jul 21, 2026, 11:24 AM EDT
Completed Phase 2 Interventional

Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms

NCT05173818
View directory record Official record
Conditions
Persistent Post-concussive Syndrome, Concussion Post Syndrome
Interventions
Hyperbaric oxygen at 1.5 ATA, Sham treatment
Drug
Lead sponsor
Essentia Health
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 21, 2026, 11:24 AM EDT