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ClinicalTrials.gov public records Last synced Oct 20, 2026, 1:54 PM EDT

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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-Concussive Syndrome Clear all
Not yet recruiting Not applicable Interventional

SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function.

NCT06882239
View directory record Official record
Conditions
Persistent Post-concussive Symptoms, Post Traumatic Headache
Interventions
SPINEPASS Physical Therapy, Standard Physical Therapy
Other
Lead sponsor
The University of Queensland
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 20, 2026, 1:54 PM EDT
Terminated No phase listed Observational

Hyperbaric Oxygen Therapy in Chronic Traumatic Brain Injury or Post-Traumatic Stress Disorder

NCT01105962
View directory record Official record
Conditions
Traumatic Brain Injury, Post-traumatic Stress Disorder
Interventions
Not listed
Lead sponsor
International Hyperbaric Medical Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
10
States / cities
San Francisco, California • Boulder, Colorado • Delray Beach, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2016 · Synced Oct 20, 2026, 1:54 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The RETINA Project: Reliable Eye Tracking in Neurocognitive Assessment of Traumatic Brain Injury

NCT01552577
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years and older
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2018 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Not applicable Interventional

Mindfulness Intervention in Young Adults With a Concussion History

NCT05399849
View directory record Official record
Conditions
Concussion, Brain, Concussion Post Syndrome
Interventions
Mindfulness Exercises and Meditations
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 30 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2022 · Synced Oct 20, 2026, 1:54 PM EDT
Recruiting Not applicable Interventional

Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)

NCT04978571
View directory record Official record
Conditions
Post-Concussion Syndrome, COVID Long-Haul, COVID-19
Interventions
percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (sham device), percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
Device
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
11 Years to 18 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Not applicable Interventional

Biopsychosocial Effect of Service Dog Training on Post-traumatic Stress (PTS) and Post Concussive Symptoms

NCT03907254
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Posttraumatic Stress Disorder, Traumatic Brain Injury
Interventions
Service Dog Training Program
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Oct 20, 2026, 1:54 PM EDT
Recruiting Phase 2 Interventional

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

NCT06073886
View directory record Official record
Conditions
Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury, Headache, Dizziness, Cognitive Symptom, Dysautonomia, Anxiety, Irritability; Syndrome, Depression, Post-traumatic Stress Disorder
Interventions
Active cTBS, Inactive/Sham cTBS, Imaginal exposure
Device · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Westwood, Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 20, 2026, 1:54 PM EDT
Not listed No phase listed Observational

Validating a Modified COMPASS 31questionnaire for Treatment Outcomes

NCT05302479
View directory record Official record
Conditions
Headache, Migraine, Persistent Post Traumatic Headache, Cervicogenic Headache
Interventions
COMPASS 31 questionnaire
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Oct 20, 2026, 1:54 PM EDT
Not yet recruiting Not applicable Interventional

Female Concussion Head Cooling

NCT07303933
View directory record Official record
Conditions
Concussion (Diagnosis), Concussion Post Syndrome, Concussion, Mild
Interventions
Brain Cooling
Device
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 27 Years · Female only
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 26, 2025 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Phase 1 Interventional

Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)

NCT00760734
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Post Concussion Syndrome, Post Traumatic Stress Disorder, Chronic Post Traumatic Stress Disorder
Interventions
Low pressure hyperbaric oxygen therapy
Drug
Lead sponsor
Paul G. Harch, M.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 20, 2026, 1:54 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Pediatric Concussion Outcomes

NCT04226365
View directory record Official record
Conditions
Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
Interventions
Nortriptyline, Placebo
Drug
Lead sponsor
Lancaster General Hospital
Other
Eligibility
13 Years to 21 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents

NCT03475693
View directory record Official record
Conditions
Concussion Post Syndrome
Interventions
Magnesium Oxide, Acetaminophen, Zofran ODT 4 MG Disintegrating Oral Tablet
Drug
Lead sponsor
Corewell Health South
Other
Eligibility
12 Years to 18 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Saint Joseph, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Oct 20, 2026, 1:54 PM EDT
Active, not recruiting Not applicable Interventional

Brain Stimulation for Concussion

NCT05889117
View directory record Official record
Conditions
Transcranial Magnetic Stimulation, Magnetic Resonance Imaging, Neuropsychological Tests, Traumatic Brain Injury, Post-Concussion Syndrome
Interventions
Intermittent theta-burst treatment (iTBS) using MagPro Transcranial Magnetic Stimulator (manufacturer: Magventure)
Device
Lead sponsor
The Mind Research Network
Other
Eligibility
18 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Oct 20, 2026, 1:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Therapeutic Resources for Attention Improvement With Neuroimaging for TBI

NCT02082509
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
8 Years to 16 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Oct 20, 2026, 1:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treatment for Patients With Chronic Post-Concussion Symptoms

NCT03759808
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion Post Syndrome
Interventions
Psychological Intervention
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 25 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 29, 2021 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Not applicable Interventional

Comparing the Effect of Osteopathic Manipulative Medicine (OMM) Versus Counseling in the Treatment of Concussion

NCT02750566
View directory record Official record
Conditions
Post-Concussion Symptoms, Distorted; Balance
Interventions
Osteopathic Manipulative Treatment, Counseling
Procedure · Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years to 50 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2024 · Synced Oct 20, 2026, 1:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury

NCT01298557
View directory record Official record
Conditions
Traumatic Brain Injury, Post-concussive Symptoms
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 50 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Not applicable Interventional

Evaluating Altius Tinted Contact Lenses as an Option Managing for Post-Concussion Visual Syndrome

NCT07869927
View directory record Official record
Conditions
Post Concussion Symptoms
Interventions
ALTIUS® daily disposable performance-tinted contact lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 20, 2026, 1:54 PM EDT
Completed No phase listed Observational

An Investigation of the Biological and Neuronal Mechanisms of Post Traumatic Stress Disorder, Depression and Post-Concussive Syndrome Onset Following a Traumatic Brain Injury

NCT02019654
View directory record Official record
Conditions
Traumatic Brain Injury, PTSD, Depression
Interventions
Not listed
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 6, 2022 · Synced Oct 20, 2026, 1:54 PM EDT
Withdrawn Phase 2 Interventional

Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury

NCT02443142
View directory record Official record
Conditions
Brain Concussion
Interventions
Ibuprofen, Acetaminophen
Drug
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Not applicable Interventional

Hyperbaric Oxygen Therapy for Post-Concussion Syndrome

NCT05643482
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
Hyperbaric Oxygen Treatment, Placebo gas
Device · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 20, 2026, 1:54 PM EDT
Terminated Phase 2 Interventional Results available

Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol

NCT01013870
View directory record Official record
Conditions
Traumatic Brain Injury, Post-traumatic Stress Disorder
Interventions
Atorvastatin, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Oct 20, 2026, 1:54 PM EDT
Recruiting No phase listed Observational

Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches

NCT04685772
View directory record Official record
Conditions
Post-Concussion Syndrome, Headache
Interventions
Methylprednisolone
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
25 participants
Timeline
2021 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 20, 2026, 1:54 PM EDT
Completed Not applicable Interventional

Care for Post-Concussive Symptoms

NCT02268240
View directory record Official record
Conditions
Concussion
Interventions
Stepped Care
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 18 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Oct 20, 2026, 1:54 PM EDT