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ClinicalTrials.gov public records Last synced Oct 20, 2026, 3:27 PM EDT

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Showing 49–72 of 223 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-Natal Depression Clear all
Completed Not applicable Interventional

MomMoodBooster VA Program

NCT05196152
View directory record Official record
Conditions
Perinatal Depression, Postpartum Depression
Interventions
MomMoodBooster, Phone Coaching
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 20, 2026, 3:27 PM EDT
Recruiting Phase 3 Interventional

Brexanolone Lifting Outcomes Of Moms

NCT07822321
View directory record Official record
Conditions
Depression, Postpartum, Postpartum Depression (PPD), Post-partum Depression, Postnatal Depression, Post-Natal Depression, Peripartum Depression
Interventions
LPCN 1154A, Placebo
Drug
Lead sponsor
Lipocine Inc.
Industry
Eligibility
15 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
16
States / cities
Tucson, Arizona • Canoga Park, California • Walnut Creek, California + 13 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 20, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional

Engage & Connect: A Psychotherapy for Postpartum Depression

NCT05585164
View directory record Official record
Conditions
Postpartum Depression
Interventions
Engage & Connect (E&C), Symptom Review and Psychoeducation (SRP)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 20, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional

In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression

NCT05766475
View directory record Official record
Conditions
Postpartum Depression
Interventions
ROSE Program: In Person, ROSE Program: Virtual
Behavioral
Lead sponsor
University of Denver
Other
Eligibility
18 Years and older · Female only
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional Results available

Postpartum Wellness

NCT04414696
View directory record Official record
Conditions
Postpartum Depression
Interventions
Exercise intervention
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication

NCT06053515
View directory record Official record
Conditions
Pregnancy, Postpartum Depression, Infant Development, Infant Conditions
Interventions
Rosie the Chatbot
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
14 Years to 99 Years · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 20, 2026, 3:27 PM EDT
Terminated Not applicable Interventional Results available

Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression

NCT02235064
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Sertraline, Placebo
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional

Efficacy of Yoga for Postpartum Depression

NCT02213601
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Yoga
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Phase 2 Interventional Results available

Preventing Postpartum Depression With Intranasal Oxytocin

NCT02505984
View directory record Official record
Conditions
Depression, Postpartum, Anxiety
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrating Text Messages Into the Mothers and Babies Course

NCT03420755
View directory record Official record
Conditions
Perinatal Depression, Postpartum Depression
Interventions
Mothers and Babies 1-on-1, Mothers and Babies Plus Text
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older · Female only
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women

NCT04285684
View directory record Official record
Conditions
Ketamine, Lactation
Interventions
ketamine in lactation
Drug
Lead sponsor
The Ketamine Research Foundation
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Anselmo, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Web-based Prevention Program for Postpartum Depression

NCT00816725
View directory record Official record
Conditions
Depression, Postpartum Depression
Interventions
Mothers and babies Internet course and PPD informational brochure
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 11, 2014 · Synced Oct 20, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Maternal Sleep and Mental Health

NCT06544941
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Sleep Disturbance, Infant Behavior, Maternal Behavior, Inflammation, Military Family
Interventions
Smart Bassinet, HALO
Device
Lead sponsor
University of Colorado, Colorado Springs
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
342 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional

Randomized Controlled Trial of the Alma Peer Mentoring Program for Pregnant Women Experiencing Depression

NCT02883686
View directory record Official record
Conditions
Depression, Depression, Postpartum
Interventions
Alma
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Aurora, Colorado • Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model

NCT04051320
View directory record Official record
Conditions
Perinatal Depression, Post Partum Depression, Depression, Postpartum, Depression
Interventions
Leuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
22 Years to 45 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2023 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood

NCT03646539
View directory record Official record
Conditions
Cognitive Therapy, Depression, Postpartum, Mental Health, Depression, Depressive Disorder, Anxiety, Telemedicine
Interventions
Use of smartphone application (app), Treatment as usual
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
201 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 20, 2026, 3:27 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Nurse Family Partnership for Women With Previous Live Births

NCT05887115
View directory record Official record
Conditions
Pregnancy, High Risk, Child Development, Post Partum Depression
Interventions
Nurse Family Partnership
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
16 Years to 46 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Phase 2 Interventional Results available

Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression

NCT02285504
View directory record Official record
Conditions
Postpartum Depression
Interventions
SAGE-547
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)

NCT02942017
View directory record Official record
Conditions
Postpartum Depression
Interventions
Placebo, SAGE-547 90 μg/kg/h
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
32
States / cities
Chandler, Arizona • Rogers, Arkansas • Lemon Grove, California + 28 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Personality Style and Self Compassion in Postpartum Depression: An Online Prevention Study

NCT02813174
View directory record Official record
Conditions
Postpartum Depression
Interventions
Compassionate Mind Training from Compassion-Focused Therapy
Behavioral
Lead sponsor
i4Health
Other
Eligibility
18 Years and older · Female only
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Oct 20, 2026, 3:27 PM EDT
Completed Phase 4 Interventional Results available

Escitalopram (Lexapro) for the Treatment of Postpartum Depression

NCT00833469
View directory record Official record
Conditions
Postpartum Depression
Interventions
Escitalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2014 · Synced Oct 20, 2026, 3:27 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

IMAGINE: Pilot Trial of a Digital Group Intervention to Prevent Perinatal Depression

NCT06746337
View directory record Official record
Conditions
Depression During Pregnancy, Depression, Postpartum
Interventions
IMAGINE
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
16 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 20, 2026, 3:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Parenting Skills Group for Mothers With Postpartum Depression

NCT05772897
View directory record Official record
Conditions
Postpartum Depression
Interventions
Circle of Security Parenting program
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2035
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 20, 2026, 3:27 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

CALM for Pregnant and Post-Partum Women

NCT03351465
View directory record Official record
Conditions
Anxiety, Depression, Depression, Postpartum, Pregnancy Related, CBT
Interventions
Coordinated Anxiety Learning and Management
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 20, 2026, 3:27 PM EDT