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ClinicalTrials.gov public records Last synced Oct 21, 2026, 2:35 AM EDT

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Showing 145–168 of 223 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-Natal Depression Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility and Acceptability of a Novel Digital Intervention to Prevent Paternal Postpartum Depression

NCT07594743
View directory record Official record
Conditions
Paternal Postpartum Depression, Postpartum Anxiety
Interventions
Together in Parenting
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Phase 2 Interventional

Use of Omega-3 Fatty Acids for Perinatal Depression

NCT00402389
View directory record Official record
Conditions
Depression, Depression, Postpartum
Interventions
Omega-3 Fatty Acids (EPA plus DHA), Supportive psychotherapy, Placebo
Drug · Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 29, 2013 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional

Treatment of Post-partum Depression Using an Behavioral Intervention Called ROSE (Reach Out, Stay Strong, Essentials for Mothers of Newborns) Delivered Using an Electronic App

NCT05518162
View directory record Official record
Conditions
Post-partum Depression
Interventions
InBloom, ROSE
Device · Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)

NCT07214597
View directory record Official record
Conditions
Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient, Usability, Length of Stay
Interventions
VoiceLove mobile phone application
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Recruiting Not applicable Interventional

Accelerated TMS for Perinatal Depression

NCT06968390
View directory record Official record
Conditions
Perinatal Depression, Post Partum Depression, Major Depressive Disorder
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Phase 2 Interventional

RE104 Safety and Efficacy Study in Postpartum Depression

NCT06342310
View directory record Official record
Conditions
Postpartum Depression
Interventions
RE104 for Injection
Drug
Lead sponsor
Reunion Neuroscience Inc
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
38
States / cities
Birmingham, Alabama • Tucson, Arizona • Santa Monica, California + 31 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum Depression

NCT05543746
View directory record Official record
Conditions
Postpartum Depression
Interventions
Brexanolone
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

PREPP: Preventing Postpartum Depression

NCT03283254
View directory record Official record
Conditions
Postpartum Depression (PPD)
Interventions
Practical Resources for Effective Postpartum Parenting (PREPP), Enhanced Treatment As Usual (ETAU)
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional

Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms: Impact on Child Development

NCT05400161
View directory record Official record
Conditions
Postpartum Depression, Parenting, Parent-Child Relations, Child Development
Interventions
MoodGym, Social Media-Based Parenting Program
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years and older · Female only
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional

Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depressive Relapse/Recurrence

NCT02387424
View directory record Official record
Conditions
Postpartum Depression, Pregnancy, Depression
Interventions
MBCT-PD, OAR
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
4
States / cities
Boulder, Colorado • Denver, Colorado • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Doula Support for Young Mothers: A Randomized Trial

NCT01925664
View directory record Official record
Conditions
Parenting, Breastfeeding, Depression, Postpartum
Interventions
Doula
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
14 Years to 21 Years · Female only
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 5, 2013 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Phase 2 Interventional

A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression

NCT06285916
View directory record Official record
Conditions
Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression, Post-Natal Depression
Interventions
NORA520 Dose 1, NORA520 Dose 2, Placebo
Drug
Lead sponsor
TWi Biotechnology, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
18
States / cities
Bentonville, Arkansas • Anaheim, California • Canoga Park, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales

NCT02210702
View directory record Official record
Conditions
Postpartum Depressive Mood, Postpartum Sexual Function
Interventions
Ethinyl Estradiol 35mcg/Norethindrone 1mg, Ethinyl Estradiol 20mcg/Norethindrone 1mg
Drug
Lead sponsor
The Jones Institute
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2014
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 7, 2014 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Childbirth-Related PTSD With Expressive Writing

NCT05662423
View directory record Official record
Conditions
PTSD (Childbirth-Related)
Interventions
Expressive Writing about Childbirth, Neutral Writing
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Phase 1 Interventional

Cognitive Behavioral Therapy Delivered Over the Internet for Women With Postpartum Depression

NCT00942721
View directory record Official record
Conditions
Postpartum Depression
Interventions
Web-based CBT for PPD
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Iowa City, Iowa • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 25, 2013 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Phase 2 Interventional Results available

The Role of Hormones in Postpartum Mood Disorders

NCT00001481
View directory record Official record
Conditions
Postpartum Depression
Interventions
Estradiol, Placebo, Progesterone, leuprolide acetate
Drug · Other
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years · Female only
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional

Lexapro in the Treatment of Patients With Postpartum Depression

NCT00277108
View directory record Official record
Conditions
Postpartum Depression
Interventions
Escitalopram (Lexapro)
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Nov 6, 2008 · Synced Oct 21, 2026, 2:35 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postpartum Thyroid Measures and Mood

NCT00565032
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2001
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 28, 2010 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Group Interpersonal Psychotherapy in Treating Women With Prenatal Depression

NCT00633178
View directory record Official record
Conditions
Depression
Interventions
Group interpersonal therapy (IPT), Treatment as usual (TAU)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Case Management Study for Postpartum Depression and Intimate Partner Violence

NCT00560027
View directory record Official record
Conditions
Postpartum Depression, Intimate Partner Violence
Interventions
Case Management by Family Support Counselor (not RCT)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Female only
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 21, 2026, 2:35 AM EDT
Recruiting Not applicable Interventional

Accelerated iTBS for Post Partum Depression

NCT03417960
View directory record Official record
Conditions
Post Partum Depression
Interventions
iTBS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Active, not recruiting Not applicable Interventional

Enhancing Mental and Physical Health of Women Veterans

NCT05050266
View directory record Official record
Conditions
Cardiovascular Diseases, Overweight, Obesity, Smoking, Hypertension, Cholesterol, Diabetes Mellitus, Prediabetic State, Pregnancy, Depression, Postpartum, Prevention, Implementation Science, Quality Improvement, Virtual Care
Interventions
EBQI, REP
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Completed No phase listed Observational

The Association Between Gut Microbiota Diversity and Postpartum Depression

NCT07227753
View directory record Official record
Conditions
Depression During Pregnancy
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 21, 2026, 2:35 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Interpersonal Treatment Program to Prevent Depression and Post-Traumatic Stress Disorder in Low-Income Pregnant Women With Partner Abuse

NCT00602732
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
The Reach Out for a Safe Environment (ROSE) program, Enhanced care as usual (ECU)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 28, 2014 · Synced Oct 21, 2026, 2:35 AM EDT