- Conditions
- Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
- Interventions
- Suvorexant 20 mg, Placebo oral tablet
- Drug
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2025
- U.S. locations
- 2
- States / cities
- Boston, Massachusetts • The Bronx, New York
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Showing 25–48
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- Conditions
- Delirium, Postoperative Delirium, Cognitive Impairment
- Interventions
- Not listed
- Lead sponsor
- Stanford University
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 250 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024
- U.S. locations
- 1
- States / cities
- Palo Alto, California
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Interventions
- Precedex (Dexmedetomidine), Placebo
- Drug
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Other
- Eligibility
- 68 Years and older
- Enrollment
- 404 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2014
- U.S. locations
- 10
- States / cities
- Miami, Florida • Baltimore, Maryland • College Park, Maryland + 7 more
- Conditions
- Emergence Delirium, Strabismus
- Interventions
- Dexmedetomidine
- Drug
- Lead sponsor
- Ochsner Health System
- Other
- Eligibility
- Up to 18 Years
- Enrollment
- 90 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018
- U.S. locations
- 1
- States / cities
- Jefferson, Louisiana
- Conditions
- Postoperative Delirium, Pain, Postoperative, Degenerative Disc Disease
- Interventions
- Erector Spinae Block, Local infiltration with local anesthetic
- Procedure
- Lead sponsor
- Rashmi Mueller
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 29 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa
- Conditions
- Myringotomy
- Interventions
- Dexmedetomidine
- Drug
- Lead sponsor
- Martin Mueller
- Other
- Eligibility
- 1 Year to 10 Years
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2013
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa
- Conditions
- Surgery, Delirium, Delirium, Post-Operative
- Interventions
- Virtual Reality Software, Traditional Orientation Methods
- Other
- Lead sponsor
- The Methodist Hospital Research Institute
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2024
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Effect of Drug, Complication of Treatment
- Interventions
- Dexmedetomidine
- Other
- Lead sponsor
- Nemours Children's Clinic
- Other
- Eligibility
- 6 Months to 5 Years
- Enrollment
- 276 participants
- Timeline
- 2022 – 2023
- U.S. locations
- 1
- States / cities
- Wilmington, Delaware
- Conditions
- Delirium
- Interventions
- Not listed
- Lead sponsor
- Johns Hopkins University
- Other
- Eligibility
- 70 Years and older
- Enrollment
- 99 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Post-operative Pain, Post-operative Nausea and Vomiting, Respiratory Depression, Confusion Postoperative
- Interventions
- ComfortSafe Care
- Procedure
- Lead sponsor
- Georgetown University
- Other
- Eligibility
- 21 Years to 75 Years
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2021
- U.S. locations
- 1
- States / cities
- Washington D.C., District of Columbia
- Conditions
- Surgery--Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia Emergence Delirium, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Nausea, Postoperative, Anesthesia Morbidity, Depression, Sleep Disorders, Circadian Rhythm
- Interventions
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Other
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 300 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2023
- U.S. locations
- 4
- States / cities
- Stanford, California • Ann Arbor, Michigan • St Louis, Missouri + 1 more
- Conditions
- Delirium
- Interventions
- IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine, IV propofol & placebo, IV dexmedetomidine & placebo
- Drug
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2019
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Emergence Delirium
- Interventions
- Personalized Music, No Music
- Behavioral
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 3 Years to 9 Years
- Enrollment
- 394 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024 – 2026
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Delirium
- Interventions
- Millipore biomarker assay plate
- Device
- Lead sponsor
- Duke University
- Other
- Eligibility
- 60 Years to 130 Years
- Enrollment
- 201 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2022
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Cardiac Catheterization, Electrophysiology Procedure, Pediatric Cardiology
- Interventions
- Standard of Care, Weighted blanket
- Other · Device
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 3 Years to 17 Years
- Enrollment
- 72 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2025
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Postoperative Delirium and Delayed Functional Recovery
- Interventions
- Aerobic Exercise Training (AET)
- Behavioral
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 55 Years to 75 Years
- Enrollment
- 3 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2020
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Agitation, Anesthesia, Pediatrics
- Interventions
- Dexmedetomidine, Saline
- Drug
- Lead sponsor
- St. Luke's-Roosevelt Hospital Center
- Other
- Eligibility
- 6 Months to 17 Years
- Enrollment
- 33 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2011
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Postoperative Pain, Delirium, Confusion, Sleep
- Interventions
- Melatonin, Placebo
- Drug
- Lead sponsor
- Hospital for Special Surgery, New York
- Other
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2013
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Post-Operative Delirium, Postoperative Cognitive Dysfunction
- Interventions
- SctO2 < 60 %.
- Procedure
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 15 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2009 – 2010
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Pain, Postoperative
- Interventions
- Caffeine Citrate, Dextrose Water
- Drug
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 71 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2020
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Delirium, Postoperative Cognitive Dysfunction
- Interventions
- Lumosity
- Device
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Other
- Eligibility
- 60 Years to 90 Years
- Enrollment
- 45 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2019
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Postoperative Delirium, Sleep, Anesthesia
- Interventions
- Dexmedetomidine, Placebo
- Drug
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 469 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2022
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Hip Fractures, Delirium
- Interventions
- Deeper sedation, Moderate sedation
- Device
- Lead sponsor
- Johns Hopkins University
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2017
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Opioid Use, Pain, Postoperative, Sleep, Delirium
- Interventions
- Melatonin, Placebo
- Dietary Supplement
- Lead sponsor
- Scripps Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 120 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2028
- U.S. locations
- 1
- States / cities
- La Jolla, California