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ClinicalTrials.gov public records Last synced Oct 24, 2026, 7:42 PM EDT

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Showing 73–96 of 128 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-Operative Delirium Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Anesthetic Depth and Postoperative Delirium Trial - 2

NCT01983384
View directory record Official record
Conditions
Delirium, Cognitive Disorders
Interventions
Processed EEG-guided anesthetic depth
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
65 Years and older
Enrollment
205 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2019 · Synced Oct 24, 2026, 7:42 PM EDT
Terminated Not applicable Interventional Results available

Does Optimized General Anesthesia Care Reduce Postoperative Delirium?

NCT02604459
View directory record Official record
Conditions
Hip Fractures, Anesthesia, Delirium
Interventions
cerebral oximeter (Fore-Sight), depth of anesthesia monitor (BIS), BP management, General anesthesia, propofol, fentanyl, sevoflurane
Device · Procedure · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
65 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Oct 24, 2026, 7:42 PM EDT
Recruiting Phase 2 Interventional

Daridorexant to Prevent Post-cardiotomy Delirium

NCT07217912
View directory record Official record
Conditions
Postoperative Cognitive Decline, Postoperative Delirium
Interventions
Daridorexant 50 mg, Placebo
Drug · Other
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Suvorexant on Post-operative Sleep Disturbance

NCT05823844
View directory record Official record
Conditions
Postoperative Insomnia, Postoperative Delirium
Interventions
Suvorexant, Placebo
Drug
Lead sponsor
Columbia University
Other
Eligibility
50 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 24, 2026, 7:42 PM EDT
Terminated Not applicable Interventional

TSA Exercise Prehabilitation in Older Adults

NCT03212300
View directory record Official record
Conditions
Postoperative Delirium and Delayed Functional Recovery
Interventions
Aerobic Exercise Training (AET)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
55 Years to 75 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2020 · Synced Oct 24, 2026, 7:42 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Confusion in the Elderly After Colon Surgery

NCT01623297
View directory record Official record
Conditions
Confusion, Inflammation, Acute Phase Reaction, Surgery, Delirium
Interventions
Not listed
Lead sponsor
New York Hospital Queens
Other
Eligibility
65 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Flushing, New York
Source: ClinicalTrials.gov public record
Updated Jun 19, 2012 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction

NCT03802396
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
CN-105, Placebo
Drug
Lead sponsor
Miles Berger, MD PhD
Other
Eligibility
60 Years and older
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

NCT00699946
View directory record Official record
Conditions
Delirium
Interventions
olanzapine, placebo
Drug
Lead sponsor
The New England Baptist Hospital
Other
Eligibility
65 Years and older
Enrollment
495 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 24, 2026, 7:42 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Preoperative Cognitive Screening in Older Spinal Surgical Patients

NCT02922634
View directory record Official record
Conditions
Cognitive Impairment, Frail Elderly Syndrome
Interventions
Mini Cog
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
70 Years and older
Enrollment
229 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Oct 24, 2026, 7:42 PM EDT
Terminated Phase 4 Interventional Results available

Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI

NCT02111447
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Propofol, Sevoflurane, Isoflurane
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
2 Years to 12 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trajectory of Recovery in the Elderly

NCT02275026
View directory record Official record
Conditions
Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
Functional magnetic resonance imaging
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
40 Years to 80 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2021 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Not applicable Interventional Results available

A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia

NCT02190903
View directory record Official record
Conditions
Postoperative Complications, Hip Fracture, Delirium
Interventions
General endotracheal anesthesia, Regional (spinal) Anesthesia
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Not applicable Interventional

Cognitive Training for the Prevention of Postoperative Delirium

NCT02963961
View directory record Official record
Conditions
Delirium
Interventions
Preoperative Cognitive Training Battery
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 24, 2021 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Not applicable Interventional

fMRI Connectivity in Fracture Hip Patients

NCT02997930
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
fMRI, Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 99 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 12, 2019 · Synced Oct 24, 2026, 7:42 PM EDT
Terminated Phase 4 Interventional

Dexamethasone and Postoperative Delirium

NCT02109081
View directory record Official record
Conditions
Delirium, Postoperative Cognitive Dysfunction
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
70 Years to 100 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 21, 2021 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Not applicable Interventional Results available

Preoperative Gabapentin for Post-tonsillectomy Pain in Children

NCT01707420
View directory record Official record
Conditions
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Interventions
Gabapentin, liquid placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
5 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 15, 2021 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Phase 2 Interventional Results available

Daridorexant to Prevent Delirium After Heart Surgery

NCT06630390
View directory record Official record
Conditions
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Interventions
Daridorexant 50 mg, Placebo
Drug · Other
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 24, 2026, 7:42 PM EDT
Active, not recruiting Not applicable Interventional

Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium

NCT03928236
View directory record Official record
Conditions
Delirium, Post-cardiac Surgery
Interventions
Limited Intraoperative Benzodiazepine, Liberal Intraoperative Benzodiazepine
Other
Lead sponsor
Population Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
15,886 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
St Louis, Missouri • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 24, 2026, 7:42 PM EDT
Completed No phase listed Observational

Impact of Impaired Cerebral Autoregulation on Postoperative Delirium in Elderly Patients Undergoing Spine Surgery

NCT01574950
View directory record Official record
Conditions
Delirium
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
70 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 26, 2015 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Not applicable Interventional

Postoperative Delirium in Patients Undergoing Radical Cystectomy

NCT03132168
View directory record Official record
Conditions
Post-operative Delirium
Interventions
Assessments, Blood Draw, Standardized Anesthetic Care
Behavioral · Procedure · Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2021 · Synced Oct 24, 2026, 7:42 PM EDT
Recruiting Not applicable Interventional

Preoperative Comprehensive Geriatric Assessment (CGA) and Postoperative Delirium

NCT07059585
View directory record Official record
Conditions
CGA
Interventions
CGA, control
Behavioral · Other
Lead sponsor
University of Miami
Other
Eligibility
60 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

REPOSE Study: Reducing Delirium by Enhancing Postoperative Sleep With Suvorexant

NCT05733286
View directory record Official record
Conditions
Delirium in Old Age
Interventions
Suvorexant 20 mg, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 24, 2026, 7:42 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain

NCT05010148
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Pain, Spinal Fusion
Interventions
Lidocaine IV, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years and older
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 24, 2026, 7:42 PM EDT
Not yet recruiting Not applicable Interventional

Prediction and Prevention of Postoperative Mortality and Morbidity

NCT06042413
View directory record Official record
Conditions
Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events, Perioperative Complications, Postoperative Cognitive Decline
Interventions
Personalized CPC Prehabilitation, Cognitive Training, Meditation, Daily Exercise, Enhanced Social Support, Proactive Bundle Interventions, Pre-operative Standard of Care, Intra-operative Standard of Care
Other · Behavioral · Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
5
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 24, 2026, 7:42 PM EDT