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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:30 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 409–432 of 1,847 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Post-Surgical Pain Clear all

Conditions: Postoperative Pain
Interventions: Magnesium sulfate; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 3 Years to 18 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Pain
Interventions: Percutaneous radiofrequency electrical nerve stimulation, Non-therapeutic stimulation; Device
Lead sponsor: Synaptrix, Inc.; Industry
Eligibility: 21 Years and older
Enrollment: 123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 5
States / cities: Daphne, Alabama • Williamsville, New York • Chapel Hill, North Carolina + 2 more

Conditions: Post Operative Pain, Total Hip Arthroplasty
Interventions: Methadone; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 75 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Strabismus
Interventions: subtenons anesthetic - preservative-free bupivacaine 0.75%, topical anesthetic - 0.5 cc of lidocaine 3.5% ophthalmic gel, topical control - 0.5 cc of Hypromellose 0.3% gel, subtenons control - 0.5 cc of Normal Saline; Drug
Lead sponsor: Duke University; Other
Eligibility: 1 Year to 7 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Opioid Use, Breast Cancer
Interventions: Addinex Device (ADX-27); Device
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Tonsillectomy, Tonsillitis Chronic, Hemorrhage, Postoperative Pain, Postoperative Hemorrhage, Surgery--Complications, Otorhinolaryngologic Diseases
Interventions: BiZact, Standard of care; Device · Procedure
Lead sponsor: Baylor College of Medicine; Other
Eligibility: Up to 18 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Postoperative Pain
Interventions: Ice; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 74 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Dallas, Texas

Conditions: Postoperative Pain
Interventions: Ketamine, Placebo, Hydromorphone PCA; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Postoperative
Interventions: Acetaminophen Intravenous, Acetaminophen Oral; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older · Female only
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Analgesia, Postoperative Pain, Block
Interventions: Ropivacaine 0.5% Injectable Solution; Drug
Lead sponsor: Bruce Ben-David; Other
Eligibility: 18 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy, Colectomy, Reduction Mammoplasty
Interventions: INL-001 (bupivacaine hydrochloride) implant; Combination Product
Lead sponsor: Innocoll; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 8
States / cities: Florence, Alabama • Sheffield, Alabama • Pasadena, California + 3 more

Conditions: Keratoconus, Unstable, Collagen Crosslinking, Postoperative Pain
Interventions: Dextenza, Prednisolone Acetate; Drug
Lead sponsor: Sight Medical Doctors PLLC; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Babylon, New York

Conditions: Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain, Vertebral Compression Fracture, Failed Back Surgery Syndrome
Interventions: Continuous intrathecal prognostic infusion test, Bupivacaine, Fentanyl, Placebo, Intrathecal Drug Delivery System (IDDS); Other · Drug · Device
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 30 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Supracondylar Humerus Fracture
Interventions: Acetaminophen-Hydrocodone, Acetaminophen and Ibuprofen; Drug
Lead sponsor: Le Bonheur Children's Hospital; Other
Eligibility: 4 Years to 13 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Post Operative Pain
Interventions: Sufentanil NanoTab PCA System/15 mcg, Placebo Sufentanil NanoTab PCA System; Drug
Lead sponsor: Talphera, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 419 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Damascus, Maryland

Conditions: Post Operative Pain
Interventions: Sufentanil NanoTab, Placebo NanoTab; Drug
Lead sponsor: Talphera, Inc; Industry
Eligibility: 45 Years to 80 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Pain, Postoperative
Interventions: Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 3 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Pertrochanteric Fracture
Interventions: Marcaine, Duramorph , ketorolac, Bupivacaine (Marcaine), General Anesthetics; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 190 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Lung Tumor
Interventions: IV Acetaminophen, Saline Placebo; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Urinary Retention Postoperative, Postoperative Urinary Tract Infection, Catheter Site Pain
Interventions: Early catheter removal; Procedure
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 99 Years · Female only
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Acute Pain
Interventions: Placebo, ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg, ibuprofen 400 mg; Drug
Lead sponsor: Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA); Industry
Eligibility: 18 Years to 50 Years
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2007
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Arthritis
Interventions: Reverse Shoulder Arthroplasty, Total Shoulder Arthroplasty; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 70 Years to 95 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Pectus Excavatum
Interventions: ON-Q soaker catheter system, Epidural (ropivicaine 0.25%); Device · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Posterolateral Thoracotomy, Postoperative Pain
Interventions: EXPAREL 266 mg, Placebo; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 191 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 7
States / cities: Miami, Florida • Shreveport, Louisiana • Fargo, North Dakota + 4 more

Search by objective public record fields.

Magnesium Sulfate for Analgesia in Pediatric Transplant

Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

Methadone in THA for Post-op Pain and Opioid Reduction

Postoperative Subtenons Anesthesia for Postoperative Pain in Pediatric Strabismus Surgery

Opioid Dispensing Device for Post-Operative Pain in Cancer Patients

BiZact Tonsillectomy in the Pediatric Population

Ice Application for Postoperative Pain

Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients

Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery

Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies

An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Determining the Prognostic Value of Continuous Intrathecal Infusion

NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures

Efficacy and Safety Trial to Evaluate the Sufentanil NanoTab® PCA System/15 mcg (Zalviso™) for Post-Operative Pain in Patients After Knee or Hip Replacement Surgery

A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Elective Unilateral Total Knee Replacement

A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain

Effects of a Surgical Site Injection on Pain Scores and Narcotic Use After Orthopaedic Trauma Surgery

Analgesic Efficacy of Intravenous Acetaminophen After Video-assisted Thoracic Surgery

Early Patient Removal of Urinary Catheters After Urogynecologic Surgery

Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction

Total vs. Reverse Shoulder Replacement: Pain Relief Two Years After Surgery

Post Operative Pain Control Using Ropivacaine and the ON-Q System in the Adult Pectus Excavatum Patient

Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy