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Showing 1–24 of 88 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Post-concussive Symptoms Clear all
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Sildenafil Treatment for Mild TBI

NCT03598140
View directory record Official record
Conditions
Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
Interventions
Sildenafil Citrate, Placebo oral capsule
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Jun 10, 2026, 2:22 PM EDT
Not listed Phase 1 Interventional

ATCell™ Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed Via Intravenous Infusion

NCT04744051
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
50 Adipose Derived Stem Cell Infusion, 150 Adipose Derived Stem Cell Infusion, 300 Adipose Derived Stem Cell Infusion, Placebo Infusion
Drug
Lead sponsor
American CryoStem Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Jun 10, 2026, 2:22 PM EDT
Completed Not applicable Interventional

Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI)

NCT03277859
View directory record Official record
Conditions
Traumatic Brain Injury, Post-concussive Headaches
Interventions
SAA-TBI
Behavioral
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 55 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Jun 10, 2026, 2:22 PM EDT
Terminated Not applicable Interventional

Post-concussion Syndrome and Chiropractic

NCT06151184
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
Chiropractic adjustment
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jun 10, 2026, 2:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Bright Light Therapy in Mild Traumatic Brain Injury

NCT01747811
View directory record Official record
Conditions
Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
Interventions
wavelength-1 bright light, wavelength-2 bright light
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Jun 10, 2026, 2:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Craniosacral Therapy for Concussion Symptoms

NCT04820192
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
Craniosacral Therapy
Other
Lead sponsor
Special Therapies, Inc.
Other
Eligibility
14 Years to 90 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Waukesha, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 28, 2021 · Synced Jun 10, 2026, 2:22 PM EDT
Not listed Not applicable Interventional

A Wrist-Worn Nerve Stimulator for Remediating Persistent Post-Concussive Symptoms in Adolescents

NCT05685121
View directory record Official record
Conditions
Concussion, Brain
Interventions
Apollo Neuro
Device
Lead sponsor
University of South Carolina
Other
Eligibility
10 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Jun 10, 2026, 2:22 PM EDT
Completed Phase 2 Interventional Results available

Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)

NCT01306968
View directory record Official record
Conditions
Post-concussive Symptoms, Traumatic Brain Injury
Interventions
hyperbaric oxygen, sham hyperbaric air
Drug · Other
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
5
States / cities
Camp Pendleton, California • Fort Carson, Colorado • Fort Gordon, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Jun 10, 2026, 2:22 PM EDT
Completed No phase listed Observational

An Investigation of the Biological and Neuronal Mechanisms of Post Traumatic Stress Disorder, Depression and Post-Concussive Syndrome Onset Following a Traumatic Brain Injury

NCT02019654
View directory record Official record
Conditions
Traumatic Brain Injury, PTSD, Depression
Interventions
Not listed
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 5, 2022 · Synced Jun 10, 2026, 2:22 PM EDT
Recruiting Not applicable Interventional

Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)

NCT04978571
View directory record Official record
Conditions
Post-Concussion Syndrome, COVID Long-Haul, COVID-19
Interventions
percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (sham device), percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
Device
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
11 Years to 18 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jun 10, 2026, 2:22 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Cerebellar TDCS for SRPCS Treatment

NCT04760899
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 30 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jun 10, 2026, 2:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eye-Tracking Rapid Attention Computation

NCT00743821
View directory record Official record
Conditions
Post Concussive Syndrome, Chronic
Interventions
Not listed
Lead sponsor
Brain Trauma Foundation
Other
Eligibility
18 Years to 55 Years
Enrollment
426 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2014 · Synced Jun 10, 2026, 2:22 PM EDT
Terminated No phase listed Observational

Hyperbaric Oxygen Therapy in Chronic Traumatic Brain Injury or Post-Traumatic Stress Disorder

NCT01105962
View directory record Official record
Conditions
Traumatic Brain Injury, Post-traumatic Stress Disorder
Interventions
Not listed
Lead sponsor
International Hyperbaric Medical Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
10
States / cities
San Francisco, California • Boulder, Colorado • Delray Beach, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2016 · Synced Jun 10, 2026, 2:22 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The RETINA Project: Reliable Eye Tracking in Neurocognitive Assessment of Traumatic Brain Injury

NCT01552577
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years and older
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2018 · Synced Jun 10, 2026, 2:22 PM EDT
Completed Not applicable Interventional

Persistent Post-Concussion Symptoms With Convergence Insufficiency

NCT05262361
View directory record Official record
Conditions
Persistent Post-concussive Symptoms, Convergence Insufficiency, Mild Traumatic Brain Injury, Concussion, Mild, Concussion; Eye
Interventions
Office-based Vergence and Accommodative Therapy
Behavioral
Lead sponsor
New Jersey Institute of Technology
Other
Eligibility
11 Years to 35 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Newark, New Jersey • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Jun 10, 2026, 2:22 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treatment for Patients With Chronic Post-Concussion Symptoms

NCT03759808
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion Post Syndrome
Interventions
Psychological Intervention
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 25 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Jun 10, 2026, 2:22 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

NCT02266329
View directory record Official record
Conditions
Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache, Mild Traumatic Brain Injury, Posttraumatic Migraine
Interventions
prazosin hydrochloride, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jun 10, 2026, 2:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)

NCT01334528
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post-Concussive Symptoms
Interventions
Not listed
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 45 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Jun 10, 2026, 2:22 PM EDT
Completed No phase listed Observational

Accelerated Transcranial Magnetic Stimulation Intervention for Post-Concussion Syndrome

NCT07211919
View directory record Official record
Conditions
Post Concussive Syndrome, Chronic, Post Concussion Symptoms, Post Concussive Syndrome, Post Concussion Syndrome, Anxiety Disorder Not Otherwise Specified
Interventions
Not listed
Lead sponsor
Cognitive FX
Industry
Eligibility
16 Years to 75 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Provo, Utah
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Jun 10, 2026, 2:22 PM EDT
Completed Not applicable Interventional

Biopsychosocial Effect of Service Dog Training on Post-traumatic Stress (PTS) and Post Concussive Symptoms

NCT03907254
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Posttraumatic Stress Disorder, Traumatic Brain Injury
Interventions
Service Dog Training Program
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jun 10, 2026, 2:22 PM EDT
Recruiting Not applicable Interventional

Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury

NCT05236010
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
rTMS, HD-tDCS, Attention Process Training
Device · Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 59 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
5
States / cities
Minneapolis, Minnesota • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jun 10, 2026, 2:22 PM EDT
Completed Not applicable Interventional

Use of Salt-Water Solution to Improve Symptoms in Concussion

NCT00142090
View directory record Official record
Conditions
Brain Concussion, Post-Concussion Symptoms
Interventions
3% Hypertonic saline, Placebo
Drug
Lead sponsor
Rady Children's Hospital, San Diego
Other
Eligibility
6 Years to 17 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2009 · Synced Jun 10, 2026, 2:22 PM EDT
Recruiting Not applicable Interventional

Facilitating Access to Specialty Treatment

NCT05741411
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
Interventions
RPM-assisted specialist access
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
13 Years to 18 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 10, 2026, 2:22 PM EDT
Active, not recruiting Not applicable Interventional

Neurotechnology Following Traumatic Brain Injury

NCT03649958
View directory record Official record
Conditions
Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
Interventions
HIRREM-SOP or Cereset, Cereset 2x
Device
Lead sponsor
Brain State Technologies, LLC
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Jun 10, 2026, 2:22 PM EDT