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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:12 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 241–264 of 714 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Post-operation Pain Clear all

Conditions: Pelvic Organ Prolapse
Interventions: IV Acetaminophen, IV normal saline; Drug
Lead sponsor: Halina M Zyczynski, MD; Other
Eligibility: 18 Years and older · Female only
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pain, Postoperative
Interventions: OxyCODONE 5 mg Oral Tablet, Acetaminophen 500Mg Tab, Naproxen 500 Mg; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use
Interventions: Music Treatment; Other
Lead sponsor: Steward St. Elizabeth's Medical Center of Boston, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Brighton, Massachusetts

Conditions: Postoperative Pain
Interventions: Acetaminophen or Placebo; Drug
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years to 90 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Bariatric Surgery Candidate, Pain, Postoperative, Nausea and Vomiting, Postoperative, Opioid Use
Interventions: Intraoperative autonomic neural blockade (ANB), Laparoscopic Standard of Care Abdominal Wall Block; Procedure
Lead sponsor: Endeavor Health; Other
Eligibility: 18 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Post-operative Pain
Interventions: Bupivacaine / Lidocaine, Lidocaine; Drug
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Myopia, Hypermetropia, Refractive Errors, Astigmatism
Interventions: Proparacaine Ophthalmic; Drug
Lead sponsor: Beeran Meghpara, MD; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Surgical Incision, Pain, Postoperative, Pain, Acute
Interventions: Bupivacaine 0.25%, Normal Saline; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Postoperative Pain
Interventions: IV Diclofenac, IV ketorolac, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 277 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 8
States / cities: Sheffield, Alabama • Phoenix, Arizona • San Clemente, California + 5 more

Conditions: Postoperative Pain
Interventions: Methadone, Hydromorphone; Drug
Lead sponsor: Endeavor Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Pain
Interventions: Lumiracoxib; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 17 Years and older
Enrollment: 364 participants
Timeline: Started 2006
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Scoliosis Idiopathic, Pain, Postoperative
Interventions: Applied VR, Apple iPad; Device
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 11 Years to 17 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Postoperative Dental Pain
Interventions: Naproxen sodium and caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine, Placebo; Drug
Lead sponsor: Bayer; Industry
Eligibility: 16 Years and older
Enrollment: 541 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Acute Postoperative Pain, Dental Pain
Interventions: CYT-1010, Placebo; Drug
Lead sponsor: Cytogel Pharma, LLC; Industry
Eligibility: 18 Years to 45 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
Interventions: Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia], Standard analgesia use [Fentanyl], Multi-modal pain management [Acetaminophen + Gabapentin], Multi-modal pain management [Fentanyl], Multi-modal pain management [Intravenous Ketamine], Multi-modal pain management [Valium + Gabapentin]; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Acute Pain
Interventions: adductor canal block, SPANK, Ropivacaine; Procedure · Drug
Lead sponsor: Bruce Ben-David; Other
Eligibility: 19 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pain, Rotator Cuff, Surgery
Interventions: Not listed
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 90 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Chronic Post-surgical Pain
Interventions: Not listed
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 8 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Pain
Interventions: Oral Acetaminophen, IV Acetaminophen, IV Morphine, Placebo Tablets, Saline; Drug
Lead sponsor: Mallinckrodt; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 3
States / cities: Tucson, Arizona • Naples, Florida • Kingston, Rhode Island

Conditions: Postoperative Nausea and Vomiting, Pain, Postoperative
Interventions: Guanfacine, Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Fracture, Pain, Postoperative
Interventions: Methadone, Morphine; Drug
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Post-traumatic Stress Symptoms, Anxiety, Depression Disorder, Gastrointestinal Disease
Interventions: PREPARE-GI; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Arthroplasty
Interventions: Tapentadol IR (CG5503), Placebo, Oxycodone HCL IR; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 367 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 45
States / cities: Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 42 more

Conditions: Ankle Surgery
Interventions: Nerve block; Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Jacksonville, Florida

Search by objective public record fields.

IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair

Pain Management After Surgery

Music Therapy for Post-cardiac Surgery Pain Management

Use of IV Acetaminophen in the Treatment of Post Operative Pain in Patients Undergoing Craniotomy and Spine Surgery

Autonomic Neural Blockade in Bariatric Surgery

A Trial Assessing The Association Between Type Of Local Anesthesia Treatment And Postoperative Pain In Patients In Having Undergone Arrhythmia Surgery

Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK)

Continuous Erector Spinae Plane Blocks to Treat Postoperative Pain After Open Gynecologic Procedures Via a Low Transverse (Pfannenstiel) Incision

Efficacy and Safety of IV Diclofenac (DIV075V)for Pain After Elective Orthopedic Surgery

Intraoperative Opioids and Postoperative Recovery After Hepatobiliary or Foregut Surgery

Efficacy of Lumiracoxib in Relieving Moderate to Severe Post-dental Surgery Pain, Compared to Both Placebo and Celecoxib

Virtual Reality After Pediatric Scoliosis Surgery

A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo

A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction

Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients

Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery

Single Shot vs Continuous Interscalene Block for Rotator Cuff Repair

Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain

Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen

Guanfacine for PONV and Pain After Sinus Surgery

Methadone Versus Morphine for Orthopedic Surgery Patients

Psychological Prehabilitation for Complex Gastrointestinal Surgery

A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety

High Ankle Block Versus Regional Block for Acute Pain Control After Ankle Surgery