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ClinicalTrials.gov public records Last synced Nov 14, 2026, 5:58 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 714 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Post-operation Pain Clear all

Conditions: Postpartum Period, Depression, Stress Disorders, Post-Traumatic
Interventions: Not listed
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older · Female only
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Ulcer Disease After Gastric Bypass, Marginal Ulcer, Perforated Marginal Ulcer, Acutely Perforated Marginal Ulcer
Interventions: Not listed
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Fresno, California

Conditions: Tooth, Impacted, Tooth Diseases, Stomatognathic Diseases
Interventions: Ibuprofen 200Mg Oral Cap, Ibuprofen 200Mg Oral Tablet, Placebo Liquid Capsule, Placebo Tablets; Drug · Other
Lead sponsor: Reckitt Benckiser Healthcare (UK) Limited; Industry
Eligibility: 16 Years to 55 Years
Enrollment: 294 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Skin Neoplasms
Interventions: Tranexamic acid injection, Lidocaine Epinephrine; Drug
Lead sponsor: Riley McLean; Other
Eligibility: 18 Years to 99 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Postoperative Pain
Interventions: CR845, Placebo; Drug
Lead sponsor: Cara Therapeutics, Inc.; Industry
Eligibility: 21 Years to 65 Years · Female only
Enrollment: 203 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 18
States / cities: Florence, Alabama • Mobile, Alabama • Montgomery, Alabama + 14 more

Conditions: Coronary Artery Disease, Sternal Pain
Interventions: Bupivacaine Group, Placebo; Drug · Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Breast Cancer, Survivorship, Pain, Postoperative
Interventions: Dance Program; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hernia, Pain, Postoperative, Abdominal Wall Relaxation After Rectus Sheath Block
Interventions: Bupivacaine, Normal Saline; Drug
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Pain, Postoperative
Interventions: Methadone, Morphine; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Pain
Interventions: IV Acetaminophen, Placebo; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Acute Pain Management, Analgesic, Nonopioid, Amputation of Lower Extremity, All Causes
Interventions: Oral Ketamine; Drug
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pain, Postoperative
Interventions: diclofenac potassium (XP21L), Placebo; Drug
Lead sponsor: Xanodyne Pharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2006
U.S. locations: 6
States / cities: Anaheim, California • Orange, California • Owings Mills, Maryland + 3 more

Conditions: Plantar Fascitis, Fat Pad Syndrome
Interventions: PopSole™ offloading device, padded insole; Device
Lead sponsor: Jeffrey A. Gusenoff, MD; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Arthropathy of Knee Joint
Interventions: Not listed
Lead sponsor: Trinity Health Of New England; Other
Eligibility: 18 Years to 85 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Sleep Apnea, Obstructive
Interventions: Coblation (radiofrequency-based device); Device
Lead sponsor: ArthroCare Corporation; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Pain, Postoperative Pain, Pain, Acute
Interventions: MR-107A-01, Placebo; Drug
Lead sponsor: Mylan Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Lower Extremity Fractures.
Interventions: Bupivacaine/Exparel; Drug
Lead sponsor: Broward Health; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Opioid Use, Unspecified
Interventions: Medication take back, Medication home disposal; Other
Lead sponsor: Indiana University; Other
Eligibility: 12 Years to 18 Years
Enrollment: 83 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Indianapolis, Indiana • New Orleans, Louisiana

Conditions: Breast Reduction, Breast Reconstruction
Interventions: Ketorolac Tromethamine, Saline; Drug · Other
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Pain
Interventions: IV ibuprofen, Ketorolac; Drug
Lead sponsor: Cumberland Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 4
States / cities: Fort Lauderdale, Florida • Chicago, Illinois • Tupelo, Mississippi + 1 more

Conditions: Post Operative Pain
Interventions: 0.25% bupivicaine will be injected at the study port site prior to incision, Saline will be injected at the study port site prior to incision, Saline will be in injected into the port site prior to closure, 0.25% bupivicaine will be injected into the port site prior to closure; Drug
Lead sponsor: Stony Brook University; Other
Eligibility: 21 Years and older · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain, Liver Transplant
Interventions: NSS-2 BRIDGE, Sham NSS-2 BRIDGE; Device
Lead sponsor: Jacques E. Chelly; Other
Eligibility: 18 Years and older
Enrollment: 286 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 4
States / cities: Pittsburgh, Pennsylvania

Conditions: Opioid Use, Pain, Post Operative
Interventions: nCAP Signal Relief Patch, Standard of Care; Device · Other
Lead sponsor: Jacques E. Chelly; Other
Eligibility: 18 Years and older
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Chronic Ocular Pain
Interventions: SAF312 Placebo, SAF312; Other · Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 24
States / cities: Mission Hills, California • Newport Beach, California • Palo Alto, California + 19 more

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Relationship Between Postpartum Mood Disorders and Delivery Experience

Perforated Marginal Ulcer After Gastric Bypass

Ibuprofen Liquid Capsules 2 x 200 mg Efficacy and PK/PD Study in Surgical Removal of Impacted Third Molars

Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery

Study to Evaluate Analgesic Effect of IV Administration of Kappa Agonist CR845 For Hysterectomy Surgery

Pecto-Intercostal Fascial Block for Postoperative Analgesia After Cardiac Surgery

Dance Study for Post-surgical Pain in Breast Cancer Survivors

Pilot Study: Rectus Sheath Blocks for Improving Abdominal Surgery Conditions

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery

Pain Control After Cardiac Surgery Using Intravenous Acetaminophen

A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery

Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery

Offloading Device for Post Surgical Foot Procedures

Postoperative Pain Management in Hospital and Following Discharge From Hospital.

Study to Evaluate Recovery From Postoperative Pain After Sleep Apnea Surgery

Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain

A Study of Postsurgical Pain Control for Lower Extremity Fractures

Investigating Interventions to Reduce Residual Opioids in the Home Following Legitimate Opioid Prescribing in Children.

Toradol (Ketorolac) in Breast Surgery to Reduce Pain & Opioid Use

Efficacy of Intravenous Ibuprofen Compared to Intravenous Ketorolac for Pain Control Following Arthroscopic Knee Surgery

Study to Compare Reduction in Pain After Surgery With and Without Local Anesthesia During Laparoscopy

Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement

A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery

Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)