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ClinicalTrials.gov public records Last synced Sep 30, 2026, 7:55 PM EDT

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Showing 25–48 of 127 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-operative Delirium Clear all
Completed Phase 4 Interventional Results available

Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy

NCT02213900
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Post-traumatic Stress Disorder, Depression, Anxiety
Interventions
Haloperidol, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 13, 2017 · Synced Sep 30, 2026, 7:55 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Organic Compounds and Postoperative Delirum

NCT05875220
View directory record Official record
Conditions
Identify Postoperative Delirium Using Exhaled Gas Patterns
Interventions
No intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
65 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational

Investigating NeuroinflammaTion UnderlyIng Postoperative Brain Connectivity Changes, POCD, Delirium in Older Adults

NCT03273335
View directory record Official record
Conditions
Delirium
Interventions
Millipore biomarker assay plate
Device
Lead sponsor
Duke University
Other
Eligibility
60 Years to 130 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Sep 30, 2026, 7:55 PM EDT
Terminated Phase 4 Interventional Results available

Cognitive Protection - Dexmedetomidine and Cognitive Reserve

NCT00455143
View directory record Official record
Conditions
Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
Interventions
Precedex (Dexmedetomidine), Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
65 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Methadone for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery

NCT03778372
View directory record Official record
Conditions
Emergence Delirium, Strabismus
Interventions
Methadone
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
0 Years to 18 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Jefferson, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Early Phase 1 Interventional Results available

Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

NCT03577730
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Caffeine Citrate, Dextrose Water
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Phase 2 Interventional

The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study

NCT05574400
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Interventions
Dextrose Water, Caffeine citrate
Drug
Lead sponsor
University of Michigan
Other
Eligibility
70 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery

NCT02546765
View directory record Official record
Conditions
Delirium
Interventions
IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine, IV propofol & placebo, IV dexmedetomidine & placebo
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational

Sleep & Postoperative Delirium in Hispanic/ Latino Patients After Cardiothoracic Surgery

NCT04786899
View directory record Official record
Conditions
Delirium in Old Age, Sleep Disturbance, Circadian Rhythm Sleep Disorder
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
50 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 29, 2022 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational

Postoperative Delirium in Hip Arthroplasty Patients

NCT02323984
View directory record Official record
Conditions
Delirium, Postoperative Complications
Interventions
miRNA Testing, Microemboli Monitoring, Delirium Assessment
Other
Lead sponsor
Ohio State University
Other
Eligibility
30 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 20, 2017 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Investigation of an Eye-Tracking Device as a Predictor of Delirium in the Recovery Room After Surgery With General Anesthesia

NCT05579093
View directory record Official record
Conditions
Delirium
Interventions
Cognitive test + Pupillary measure
Combination Product
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
325 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial

NCT00835159
View directory record Official record
Conditions
Delirium, Postoperative Cognitive Dysfunction
Interventions
Rivastigmine Patch, Placebo Patch
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2015 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Phase 3 Interventional Results available

Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children

NCT00857727
View directory record Official record
Conditions
Agitation, Anesthesia, Pediatrics
Interventions
Dexmedetomidine, Saline
Drug
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
6 Months to 17 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 27, 2018 · Synced Sep 30, 2026, 7:55 PM EDT
Not yet recruiting Not applicable Interventional

Prediction and Prevention of Postoperative Mortality and Morbidity

NCT06042413
View directory record Official record
Conditions
Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events, Perioperative Complications, Postoperative Cognitive Decline
Interventions
Personalized CPC Prehabilitation, Cognitive Training, Meditation, Daily Exercise, Enhanced Social Support, Proactive Bundle Interventions, Pre-operative Standard of Care, Intra-operative Standard of Care
Other · Behavioral · Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
5
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neuroinflammation and Postoperative Delirium in Cardiac Surgery

NCT02688179
View directory record Official record
Conditions
Delirium, Cardiac Surgery
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
630 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Phase 2 Interventional Results available

Daridorexant to Prevent Delirium After Heart Surgery

NCT06630390
View directory record Official record
Conditions
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Interventions
Daridorexant 50 mg, Placebo
Drug · Other
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Sep 30, 2026, 7:55 PM EDT
Recruiting No phase listed Observational

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

NCT06052397
View directory record Official record
Conditions
Delirium, Postoperative, Cognitive Decline, Dementia
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
70 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Not applicable Interventional Results available

Prevention of Early Postoperative Decline

NCT02908464
View directory record Official record
Conditions
Delirium, Postoperative Cognitive Dysfunction
Interventions
Lumosity
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years to 90 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational

Postoperative Delirium: EEG Markers of Sleep and Wakefulness

NCT03291626
View directory record Official record
Conditions
Postoperative Delirium
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stanford PIPRA Validation Study in an Elderly Orthopedic Population

NCT06567574
View directory record Official record
Conditions
Delirium, Postoperative Delirium, Cognitive Impairment
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
65 Years and older
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Sep 30, 2026, 7:55 PM EDT
Terminated Phase 4 Interventional

Dexamethasone and Postoperative Delirium

NCT02109081
View directory record Official record
Conditions
Delirium, Postoperative Cognitive Dysfunction
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
70 Years to 100 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 21, 2021 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Phase 2 Interventional Results available

Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period

NCT00586196
View directory record Official record
Conditions
Delirium
Interventions
donepezil, Placebo
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
70 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 22, 2014 · Synced Sep 30, 2026, 7:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stanford ICU Delirium PIPRA Study

NCT06519890
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Delirium, Postoperative
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Sep 30, 2026, 7:55 PM EDT
Completed Phase 4 Interventional Results available

Propofol in Emergence Agitation

NCT00535613
View directory record Official record
Conditions
Emergence Agitation
Interventions
Propofol
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
12 Months to 6 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Sep 30, 2026, 7:55 PM EDT