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ClinicalTrials.gov public records Last synced Oct 17, 2026, 9:16 PM EDT

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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-stroke Depression Clear all
Completed Not applicable Interventional Results available

Mindfulness Based Stress Reduction and Post-Stroke Cognition

NCT04302493
View directory record Official record
Conditions
Stroke, Stroke Sequelae, Depression, Cognitive Impairment
Interventions
Mindfulness Based Stress Reduction (MBSR), Stroke Support Group (SSG)
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 17, 2026, 9:16 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Post-stroke Psychosocial Recovery

NCT05380037
View directory record Official record
Conditions
Stroke
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 17, 2026, 9:16 PM EDT
Terminated Not applicable Interventional

Investigating Effects of High-intensity Gait Training on Gait, Balance and Depression Post-stroke

NCT06373107
View directory record Official record
Conditions
Stroke
Interventions
High intensity gait training
Behavioral
Lead sponsor
Alvernia University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Allentown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional Results available

Exercise and Brain Stimulation for Post-stroke Depression

NCT03056287
View directory record Official record
Conditions
Stroke
Interventions
Aerobic exercise, Repetitive transcranial magnetic stimulation
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 17, 2026, 9:16 PM EDT
Recruiting Not applicable Interventional

Physical Capacity Building for Chronic Stroke

NCT07039305
View directory record Official record
Conditions
Stroke, Post-stroke Depression
Interventions
Physical capacity training for chronic stroke - building aerobic capacity and muscle strength
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional Results available

TMS for Post Stroke Depression

NCT04093843
View directory record Official record
Conditions
Post-stroke Depression
Interventions
TMS
Device
Lead sponsor
Amelia Adcock
Other
Eligibility
22 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 29, 2022 · Synced Oct 17, 2026, 9:16 PM EDT
Terminated Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke Apathy

NCT02915484
View directory record Official record
Conditions
Apathy, Stroke
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 3, 2017 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional

Living Well With Stroke

NCT01133106
View directory record Official record
Conditions
Cerebrovascular Stroke, Depression
Interventions
Brief pleasurable events/behavioral therapy, Standard care
Behavioral · Other
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 23, 2016 · Synced Oct 17, 2026, 9:16 PM EDT
Not listed Phase 1 Interventional

Use of Transmucosal Ketamine in Post Stroke Depression

NCT04876066
View directory record Official record
Conditions
Post-stroke Depression
Interventions
Ketamine
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 29, 2022 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional Results available

Internet-based CBT After Stroke Pilot

NCT03615079
View directory record Official record
Conditions
Stroke, Depression
Interventions
Cognitive behavioral therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 11, 2021 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional Results available

Implementing Evidence in the Detection and Treatment of Post Stroke Depression

NCT00296140
View directory record Official record
Conditions
Mental Health, Neurology, Health Services
Interventions
self management of PSD symptoms, screening and treatment of PSD
Behavioral · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Gainesville, Florida • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Oct 17, 2026, 9:16 PM EDT
Recruiting Phase 2 Interventional

Allopregnanolone (Zuranolone) in Post-stroke Depression

NCT06759558
View directory record Official record
Conditions
Post Stroke Depression
Interventions
Zuranolone
Drug
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 17, 2026, 9:16 PM EDT
Recruiting Phase 2 Interventional

A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

NCT05507138
View directory record Official record
Conditions
Executive Dysfunction, Depression, Stroke
Interventions
AKL-T01, Metacognitive Strategy Training
Device · Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 79 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional

Preventing Post-Stroke Depression

NCT00071643
View directory record Official record
Conditions
Depression, Cerebrovascular Accident
Interventions
Problem Solving Therapy, Escitalopram, Placebo
Behavioral · Drug · Other
Lead sponsor
Robert G. Robinson
Other
Eligibility
31 Years to 89 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
3
States / cities
Chicago, Illinois • Iowa City, Iowa • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2017 · Synced Oct 17, 2026, 9:16 PM EDT
Recruiting Not applicable Interventional

Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

NCT06864715
View directory record Official record
Conditions
Post-stroke Depression, Subthreshold Depression
Interventions
Tele-delivered Behavioral Activation by lay counselors after Stroke (Tele-BA-S), Treatment as Usual
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
55 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Remote Bimanual Virtual Rehabilitation Post CVD

NCT04713384
View directory record Official record
Conditions
Stroke Sequelae, Cognitive Impairment, Depression
Interventions
Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
Device
Lead sponsor
Grigore Burdea
Industry
Eligibility
48 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Oct 17, 2026, 9:16 PM EDT
Terminated Phase 4 Interventional

Sertraline for Preventing Post-stroke Depression and Improving Rehabilitation Outcomes

NCT00177424
View directory record Official record
Conditions
Cerebrovascular Accident, Depression
Interventions
sertraline, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
40 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 27, 2014 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Phase 2 Interventional Results available

Post-Stroke Optimization of Walking Using Explosive Resistance

NCT03826771
View directory record Official record
Conditions
Stroke, Depression
Interventions
Power training, Stretching
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional

MEditation for Post Stroke Depression

NCT03239132
View directory record Official record
Conditions
Stroke, Depression
Interventions
Breath-based meditation, Meditation educational materials
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2023 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional

Ecosystem Focused Therapy in Post Stroke Depression

NCT01624402
View directory record Official record
Conditions
Depression, Stroke
Interventions
Education on Stroke and Depression (ESD), Ecosystem Focused Therapy (EFT)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
3
States / cities
New York, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Feb 6, 2019 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Phase 4 Interventional Results available

Treatment for Post-Stroke Depression

NCT00029172
View directory record Official record
Conditions
Stroke, Depression
Interventions
case management
Other
Lead sponsor
Indiana University
Other
Eligibility
Not listed
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
4
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing an EEG Probe for Studying and Modulating Cognitive Control

NCT05612659
View directory record Official record
Conditions
Post-stroke Depression
Interventions
Transcranial Electrical stimulation, Transcutaneous direct current stimulation
Procedure
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Oct 17, 2026, 9:16 PM EDT
Completed Not applicable Interventional

Psychosocial/Behavioral Intervention in Post-Stroke Depression

NCT00194454
View directory record Official record
Conditions
Stroke
Interventions
Modified cognitive behavioral therapy plus problem-solving, usual care
Behavioral · Other
Lead sponsor
University of Washington
Other
Eligibility
21 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 23, 2008 · Synced Oct 17, 2026, 9:16 PM EDT
Completed No phase listed Observational Results available

Inflammation and Post-Stroke Depression

NCT02368145
View directory record Official record
Conditions
Stroke, Acute Stroke
Interventions
Not listed
Lead sponsor
Alexander Kusnecov, Ph.D.
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 17, 2026, 9:16 PM EDT