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ClinicalTrials.gov public records Last synced Nov 6, 2026, 9:42 AM EST

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Showing 1–24 of 55 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Post-traumatic Brain Injury Depression Clear all

Conditions: Posttraumatic Stress Disorder
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2000
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: TBI (Traumatic Brain Injury), Depressive Disorder, Major, Clinical Depression, Mood Depressed, Physical Inactivity
Interventions: InMotion; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 64 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression, Opioid Use Disorder
Interventions: FORT-A, VA Treatment as Usual; Behavioral · Other
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 72 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Depression
Interventions: Sertraline, Placebo; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: New York, New York

Conditions: Mild Traumatic Brain Injury, Posttraumatic Stress Disorders, Depression
Interventions: Multifamily Group for mTBI for Couples, Group Health Education (GHE); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 249 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 3
States / cities: Baltimore, Maryland • New York, New York • The Bronx, New York

Conditions: Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression, Anxiety Disorders, Suicide, Pain
Interventions: STEP-Home, PCGT; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 221 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Boston, Massachusetts • Houston, Texas

Conditions: Concussion, Brain, TBI, Depression, Anxiety
Interventions: Collaborative Care; Behavioral
Lead sponsor: Seattle Children's Hospital; Other
Eligibility: 11 Years to 18 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
Interventions: HIRREM-SOP or Cereset, Cereset 2x; Device
Lead sponsor: Brain State Technologies, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 2
States / cities: Bethesda, Maryland • Fort Bragg, North Carolina

Conditions: Post Traumatic Stress Disorder, Major Depressive Disorder
Interventions: Transcranial Magnetic Stimulation (TMS), Task, fMRI-guided TMS target; Device · Behavioral · Procedure
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS), Autoimmune Encephalitis, Celiac Disease, Celiac Disease in Children, Chronic Lyme Disease, Post-treatment Lyme Disease Syndrome, Crohn's Disease, Dysautonomia, Anorexia Nervosa, Bulimia Nervosa, ARFID, Avoidant / Restrictive Food Intake Disorder, Ehlers Danlos Syndrome, Endometriosis, Fibromyalgia (FM), Long COVID, Lupus, Migraines, Mast Cell Activation Syndrome, Multiple Sclerosis, Myalgic Encephalomyelitis (ME), Myasthenia Gravis, Generalized, Myasthenia Gravis in Children, Narcolepsy, Obsessive Compulsive Disorder (OCD), PANDAS, Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), POTS - Postural Orthostatic Tachycardia Syndrome, General Anxiety Disorder, Social Anxiety Disorder, PTSD - Post Traumatic Stress Disorder, Psoriasis, Traumatic Brain Injury, Tourette's Syndrome, Inflammatory Bowel Disease (IBD), Autoimmune Diseases, Neurological Diseases or Conditions, Psychiatric Disorder, Sjogren's Syndrome, Ulcerative Colitis and Crohn's Disease
Interventions: Not listed
Lead sponsor: Brain Inflammation Collaborative; Other
Eligibility: 2 Years and older
Enrollment: 10,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2030
U.S. locations: 1
States / cities: Delafield, Wisconsin

Conditions: Emotional Distress
Interventions: Mood tracker ratings; Behavioral
Lead sponsor: Memorial Hermann Health System; Other
Eligibility: 18 Years to 62 Years
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury, Alcohol Use, Drug Use
Interventions: Stepped Care Management; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 14 Years and older
Enrollment: 121 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression, Post Concussion Symptoms
Interventions: Hyperbaric Oxygen Therapy (HBOT); Drug
Lead sponsor: Summit Hyperbarics and Wellness; Other
Eligibility: 18 Years to 75 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Boise, Idaho

Conditions: Traumatic Brain Injury (TBI) Patients
Interventions: Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT; Other · Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 25 Years to 64 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: PTSD, Depression, Substance Use Disorder, Traumatic Brain Injury
Interventions: WEB-ED+ Treatment Arm; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 1,312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury, Headache, Dizziness, Cognitive Symptom, Dysautonomia, Anxiety, Irritability; Syndrome, Depression, Post-traumatic Stress Disorder
Interventions: Active cTBS, Inactive/Sham cTBS, Imaginal exposure; Device · Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Westwood, Los Angeles, California

Conditions: OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer, Migraine, PTSD, PTSD - Post Traumatic Stress Disorder, Addiction, Tobacco Use Disorder, Obsessive Compulsive Disorder (OCD), Opioid Use Disorder
Interventions: Serotonergic Psychedelic, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Hamden, Connecticut • West Haven, Connecticut

Conditions: Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress, Sleep, Memory Impairment, Cognitive Behavioral Therapy, Concussion, Brain, Head Injury, Brain Injury Traumatic Mild
Interventions: Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I); Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 5
States / cities: Eglin Air Force Base, Florida • Bethesda, Maryland • Fort Bragg, North Carolina + 1 more

Conditions: Post-traumatic Brain Injury Depression, Veteran Health
Interventions: Active Low-Intensity Focused Ultrasound (LIFU), Sham Low-Intensity Focused Ultrasound (LIFU); Device · Other
Lead sponsor: Stanford University; Other
Eligibility: 22 Years to 55 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Stanford, California

Conditions: Healthy, Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 7 Years to 18 Years
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2012
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Traumatic Brain Injury
Interventions: Not listed
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 80 Years
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 4
States / cities: Miami, Florida • Cincinnati, Ohio • Pittsburgh, Pennsylvania + 1 more

Conditions: TBI (Traumatic Brain Injury)
Interventions: Venlafaxine; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache, Chronic Insomnia, Chronic Attention Disorder
Interventions: Neurofeedback (NFB); Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Traumatic Brain Injury, Post Concussive Symptoms, Depression, Executive Dysfunction
Interventions: Anodal tDCS, Cognitive training; Device · Behavioral
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years to 55 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Search by objective public record fields.

Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Chronic Posttraumatic Stress Disorder (PTSD)

InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI

Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans

Treatment of Post-Traumatic Brain Injury (TBI) Depression

Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBI

Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop

Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth

Neurotechnology Following Traumatic Brain Injury

Accelerated TMS to a Novel Brain Target in MDD and PTSD

Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

Mood Tracker Smartphone App for Management of Emotional Distress After TBI

Trauma Survivors Outcomes and Support Study IV

HBOT Effects on First Responders' Cognition and Well-Being

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Development of Low-Intensity Focused Ultrasound for Post Traumatic Brain Injury Depression

Brain Function in Mentally Ill Adolescents

Observational Study of Cortical Spreading Depression in Human Brain Trauma

Pharmacological Intervention in Depression After Traumatic Brain Injury

Neurofeedback Impact on Veterans With mTBI

Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury