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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: PostPartum Depression Clear all
Completed Not applicable Interventional

Intervention for IPV-exposed Pregnant Women

NCT04068662
View directory record Official record
Conditions
Postpartum Depression, Posttraumatic Stress Disorder, Infant Behavior, Violence, Parenting
Interventions
Pregnant Moms' Empowerment Program, Nondirective Support Group
Behavioral
Lead sponsor
University of Notre Dame
Other
Eligibility
3 Months to 55 Years · Female only
Enrollment
424 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Notre Dame, Indiana • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional

MomMoodBooster VA Program

NCT05196152
View directory record Official record
Conditions
Perinatal Depression, Postpartum Depression
Interventions
MomMoodBooster, Phone Coaching
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Integrated Chronotherapy for Perinatal Depression

NCT02053649
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Postpartum Depression
Interventions
Triple Chronotherapy, Usual Care
Behavioral · Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 28, 2019 · Synced Sep 7, 2026, 1:04 PM EDT
Not listed Not applicable Interventional

Translating Research Into Practice for Postpartum Depression

NCT00548743
View directory record Official record
Conditions
Postpartum Depression
Interventions
Screening and follow up, Usual care
Behavioral
Lead sponsor
Olmsted Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 3, 2007 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study)

NCT00951717
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
Behavioral education intervention
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
590 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2011 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Yoga in the NICU for Parents Study

NCT05322161
View directory record Official record
Conditions
Postpartum Depression, Anxiety, Depression, Stress Disorder, Prematurity
Interventions
yoga classes
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Not listed
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Sep 7, 2026, 1:04 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum Depression

NCT05543746
View directory record Official record
Conditions
Postpartum Depression
Interventions
Brexanolone
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Sep 7, 2026, 1:04 PM EDT
Recruiting No phase listed Observational

A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy

NCT07047820
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Zuranolone
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Woonsocket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 7, 2026, 1:04 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postpartum Depression and Cesarean Section

NCT00370903
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
15 Years to 43 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 3, 2008 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

Personalized Integrated Chronotherapy for Perinatal Depression

NCT04364646
View directory record Official record
Conditions
Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation, Pregnancy Related, Sleep Disturbance
Interventions
Personalized Integrated Chronotherapy
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Glen Oaks, New York • Chapel Hill, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention

NCT06365645
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Stress
Interventions
M.Bapp, App-based parenting education
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Phase 4 Interventional Results available

Escitalopram (Lexapro) for the Treatment of Postpartum Depression

NCT00833469
View directory record Official record
Conditions
Postpartum Depression
Interventions
Escitalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2014 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Depression Prevention for Pregnant Women on Public Assistance

NCT00601757
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
The Postpartum Prevention Program (PPP), Enhanced care as usual (ECU)
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
207 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
3
States / cities
Providence, Rhode Island • Woonsocket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 30, 2014 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

PREPP: Preventing Postpartum Depression

NCT03283254
View directory record Official record
Conditions
Postpartum Depression (PPD)
Interventions
Practical Resources for Effective Postpartum Parenting (PREPP), Enhanced Treatment As Usual (ETAU)
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 7, 2026, 1:04 PM EDT
Recruiting Not applicable Interventional

Feasibility and Acceptability of a Novel Cognitive Behavioral Skills Mobile App for Pregnant and Postpartum Individuals

NCT05897619
View directory record Official record
Conditions
Perinatal Anxiety, Perinatal Depression
Interventions
Experimental: Maya Perinatal Cognitive Behavioral Skills App
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 7, 2026, 1:04 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Improving Maternal Mental Health & SUD Screening and Treatment

NCT05764213
View directory record Official record
Conditions
Mental Health Issue, Substance Use Disorders, Postpartum Depression, Postpartum Anxiety
Interventions
Listening to Women & Pregnant and Postpartum People
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10,470 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Web-based Prevention Program for Postpartum Depression

NCT00816725
View directory record Official record
Conditions
Depression, Postpartum Depression
Interventions
Mothers and babies Internet course and PPD informational brochure
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2014 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Virtual Group Psychoeducational Discussions With Spanish-Speaking Mothers of Infants in Pediatric Primary Care

NCT05423093
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety
Interventions
Single-Session Virtual Group Psychoeducational Session about Postpartum Depression
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
16 Years to 99 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Sep 7, 2026, 1:04 PM EDT
Not listed Phase 2 Interventional

A Dyadic Approach to Perinatal Depression in Primary Care: Maternal Infant and Dyadic Care

NCT04998721
View directory record Official record
Conditions
Depression, Postpartum, Efficacy, Self, Anxiety
Interventions
Promoting First Relationships-Brief, Perinatal Collaborative Care
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 21, 2023 · Synced Sep 7, 2026, 1:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

NCT05624931
View directory record Official record
Conditions
Depression, Posttraumatic Stress Disorder, Pregnancy Related, Medication Adherence
Interventions
Brief CBT-Based Intervention, Enhanced Treatment as Usual
Behavioral · Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
15 Years and older · Female only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Randomized Controlled Trial of the Alma Peer Mentoring Program for Pregnant Women Experiencing Depression

NCT02883686
View directory record Official record
Conditions
Depression, Depression, Postpartum
Interventions
Alma
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Aurora, Colorado • Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated May 5, 2020 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Phase 2 Interventional

RE104 Safety and Efficacy Study in Postpartum Depression

NCT06342310
View directory record Official record
Conditions
Postpartum Depression
Interventions
RE104 for Injection
Drug
Lead sponsor
Reunion Neuroscience Inc
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
38
States / cities
Birmingham, Alabama • Tucson, Arizona • Santa Monica, California + 31 more
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Efficacy of Yoga for Postpartum Depression

NCT02213601
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Yoga
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced Sep 7, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Family Nurture Intervention in the NICU

NCT02710474
View directory record Official record
Conditions
Premature Birth, Obstetric Labor, Premature
Interventions
Family Nurture Intervention, Standard Care
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
26 Weeks to 34 Weeks
Enrollment
461 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
New York, New York • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Sep 7, 2026, 1:04 PM EDT