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ClinicalTrials.gov public records Last synced Oct 23, 2026, 3:20 PM EDT

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Showing 145–168 of 249 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: PostPartum Depression Clear all
Recruiting Not applicable Interventional

Maternal Stress on Human Milk and Infant Outcomes

NCT04821544
View directory record Official record
Conditions
Postpartum Depression, Preterm Labor
Interventions
Mindfulness-based intervention (with a focus on self-compassion; MBSC), Vitamin D
Behavioral · Dietary Supplement
Lead sponsor
University of Idaho
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Coeur d'Alene, Idaho
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 23, 2026, 3:20 PM EDT
Terminated Not applicable Interventional Results available

Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression

NCT02235064
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Sertraline, Placebo
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 23, 2026, 3:20 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of CES in New Mothers During the Post Partum Period

NCT03210155
View directory record Official record
Conditions
Anxiety, Depression, Insomnia, Sleep Quality
Interventions
Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator)
Device
Lead sponsor
Christina Murphey, RN, PhD
Individual
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Austin, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Not applicable Interventional

MOMCare: Culturally Relevant Treatment Services for Perinatal Depression

NCT01045655
View directory record Official record
Conditions
Depression
Interventions
MOMCare
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 15, 2016 · Synced Oct 23, 2026, 3:20 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression?

NCT02272387
View directory record Official record
Conditions
Depression, Postpartum Depression
Interventions
Vitamin D3 (Cholecalciferol), Placebo
Dietary Supplement · Other
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years and older · Female only
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 24, 2017 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Not applicable Interventional

Treatment of Post-partum Depression Using an Behavioral Intervention Called ROSE (Reach Out, Stay Strong, Essentials for Mothers of Newborns) Delivered Using an Electronic App

NCT05518162
View directory record Official record
Conditions
Post-partum Depression
Interventions
InBloom, ROSE
Device · Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Phase 2 Interventional Results available

Inhaled Oxytocin and HPA Axis Reactivity

NCT03593473
View directory record Official record
Conditions
Depression, Postpartum, Anxiety Disorders, Stress, Psychological
Interventions
Intranasal Oxytocin, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 8, 2025 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Not applicable Interventional

Randomized Controlled Trial of the Alma Peer Mentoring Program for Pregnant Women Experiencing Depression

NCT02883686
View directory record Official record
Conditions
Depression, Depression, Postpartum
Interventions
Alma
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Aurora, Colorado • Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Not applicable Interventional

The Impact of a Newborn Behavioral Intervention on the Mental Health of Mothers With Late Pre-Term Infants

NCT03836430
View directory record Official record
Conditions
Postpartum Depression, Preterm Infant, Infant Development
Interventions
Newborn Behavioral Observation-Family Wellness (NBO-FW)
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Virtual Reality Biofeedback for Postpartum Anxiety and Depression

NCT04925765
View directory record Official record
Conditions
Anxiety and Depression, Postpartum Depression, Pregnancy Related
Interventions
Virtual Reality Biofeedback Session
Other
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years and older · Female only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Oct 23, 2026, 3:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Maternal Sleep and Mental Health

NCT06544941
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Sleep Disturbance, Infant Behavior, Maternal Behavior, Inflammation, Military Family
Interventions
Smart Bassinet, HALO
Device
Lead sponsor
University of Colorado, Colorado Springs
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
342 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Phase 4 Interventional Results available

Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries

NCT03470675
View directory record Official record
Conditions
Pain, Postpartum Depression
Interventions
Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Exercise on Perinatal Depression

NCT02791932
View directory record Official record
Conditions
Pregnancy, Postpartum Period, Depression
Interventions
Exercise
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older · Female only
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Oct 23, 2026, 3:20 PM EDT
Withdrawn Phase 2Phase 3 Interventional

The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series

NCT06048263
View directory record Official record
Conditions
Postpartum Depression
Interventions
interpersonal psychotherapy (IPT), Ketamine
Behavioral · Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 23, 2026, 3:20 PM EDT
Active, not recruiting Not applicable Interventional

Living Healthy for Moms RCT

NCT06666400
View directory record Official record
Conditions
Postpartum Depression (PPD), Cardiac Event
Interventions
LHMoms Intervention, No intervention
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
4
States / cities
Brooklyn, New York • Jamaica, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Not applicable Interventional

Postpartum Visit Timing and the Effect on Visit Attendance

NCT05399784
View directory record Official record
Conditions
Postpartum Disorder, Postpartum Depression, Postpartum Weight Retention, Breastfeeding, Satisfaction, Patient, Trust
Interventions
Early postpartum visit, Standard postpartum visit
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
13 Years to 50 Years · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 2, 2023 · Synced Oct 23, 2026, 3:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postpartum Thyroid Measures and Mood

NCT00565032
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2001
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 28, 2010 · Synced Oct 23, 2026, 3:20 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy

NCT03809572
View directory record Official record
Conditions
Maternal Psychological Distress, Postpartum Depression, Prenatal Stress
Interventions
Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Oct 23, 2026, 3:20 PM EDT
Completed No phase listed Observational

Relationship Between Postpartum Mood Disorders and Delivery Experience

NCT03004872
View directory record Official record
Conditions
Postpartum Period, Depression, Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 12, 2019 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Depression Prevention for Pregnant Women on Public Assistance

NCT00601757
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
The Postpartum Prevention Program (PPP), Enhanced care as usual (ECU)
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
207 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
3
States / cities
Providence, Rhode Island • Woonsocket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 31, 2014 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression

NCT02978326
View directory record Official record
Conditions
Postpartum Depression
Interventions
SAGE-217 15/20 mg Oral Solution, Placebo, SAGE 217 30 mg Capsules
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
27
States / cities
Little Rock, Arkansas • Beverly Hills, California • Oceanside, California + 24 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2023 · Synced Oct 23, 2026, 3:20 PM EDT
Withdrawn Not applicable Interventional

Preventing Postpartum Depression in Prenatal Care

NCT02741206
View directory record Official record
Conditions
Post-partum Depression
Interventions
Bellevue ROSE Intervention, Psycho-education session and usual, Standard of care Control, One Psycho-education session and usual, standard of care Control
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 22, 2017 · Synced Oct 23, 2026, 3:20 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)

NCT02942004
View directory record Official record
Conditions
Postpartum Depression
Interventions
Placebo, SAGE-547 60 μg/kg/h, SAGE-547 90 μg/kg/h
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
32
States / cities
Chandler, Arizona • Rogers, Arkansas • Lemon Grove, California + 27 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 23, 2026, 3:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Maternal Mental Health Access - MaMa

NCT06049433
View directory record Official record
Conditions
Postpartum Depression, Perinatal Depression
Interventions
Maternal Mental Health Access for Postpartum Depression- Prevention and UPLIFT- intervention, On-Demand + Discussion board (DB), Arm 2, On Demand (OD) + Video Conference (VC), Arm 3
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 23, 2026, 3:20 PM EDT