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ClinicalTrials.gov public records Last synced Oct 23, 2026, 5:20 PM EDT

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Showing 169–192 of 249 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: PostPartum Depression Clear all
Withdrawn Not applicable Interventional

Duloxetine for the Treatment of Postpartum Depression

NCT00617045
View directory record Official record
Conditions
Postpartum Depression, Major Depressive Disorder
Interventions
duloxetine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 17, 2016 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional

Mother-Infant Intervention for Postpartum Depression and Associated Mother-Infant Relationship Dysfunction

NCT02057627
View directory record Official record
Conditions
Postpartum Depression
Interventions
Perinatal Dyadic Psychotherapy, Placebo Comparator
Behavioral
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2016 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Exercise and Wellness Interventions on Preventing Postpartum Depression

NCT01883479
View directory record Official record
Conditions
Postpartum Depression
Interventions
Exercise, Wellness/Support
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 29, 2017 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Patient Navigation During a Pandemic

NCT06208852
View directory record Official record
Conditions
Post-partum Depression
Interventions
Virtual Navigator Program
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years and older · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Depression Prevention Program for American Indian Adolescents During and After Pregnancy

NCT00183547
View directory record Official record
Conditions
Depression, Pregnancy
Interventions
"Living in Harmony" depression prevention program, Depression-prevention education and support
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
15 Years to 19 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
2
States / cities
Whiteriver, Arizona • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional Results available

The Effects of Light Therapy on Circadian Rhythms, Sleep, and Mood in Postpartum Depression

NCT02769858
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Light therapy
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Phase 2 Interventional Results available

The Role of Hormones in Postpartum Mood Disorders

NCT00001481
View directory record Official record
Conditions
Postpartum Depression
Interventions
Estradiol, Placebo, Progesterone, leuprolide acetate
Drug · Other
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years · Female only
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 23, 2026, 5:20 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Preventing Postpartum Depression in Immigrant Latinas

NCT05873569
View directory record Official record
Conditions
Postpartum Depression
Interventions
Mothers and Babies Virtual Group Intervention
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 23, 2026, 5:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of Pregnant and Postpartum Women With and Without Mood Disorders

NCT03615794
View directory record Official record
Conditions
Bipolar Disorder, Major Depressive Disorder, Postpartum Depression, Postpartum Psychosis
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
2
States / cities
Baltimore, Maryland • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional

The Staying Well Study: An Open Trial of Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depression

NCT02391870
View directory record Official record
Conditions
Pregnancy, Depression, Postpartum Depression
Interventions
MBCT-PD
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
4
States / cities
Boulder, Colorado • Denver, Colorado • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Oct 23, 2026, 5:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Perinatal Emotion and Relationships Longitudinal Study

NCT03027037
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Not listed
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional

Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention

NCT06365645
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Stress
Interventions
M.Bapp, App-based parenting education
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional

Family Nurture Intervention in the NICU at The Valley Hospital

NCT03267043
View directory record Official record
Conditions
Premature Birth, Obstetric Labor, Premature
Interventions
Family Nurture Intervention (FNI), Standard Care
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
26 Weeks to 34 Weeks
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Ridgewood, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 23, 2026, 5:20 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales

NCT02210702
View directory record Official record
Conditions
Postpartum Depressive Mood, Postpartum Sexual Function
Interventions
Ethinyl Estradiol 35mcg/Norethindrone 1mg, Ethinyl Estradiol 20mcg/Norethindrone 1mg
Drug
Lead sponsor
The Jones Institute
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2014
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 7, 2014 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Postpartum Weight Retention

NCT02867631
View directory record Official record
Conditions
Obesity, Hypertension, Depression
Interventions
6 week challenge with 1 year of home visits: health texting, in home exercise supports, social support, healthy eating and feeding classes
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
Female only
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Phase 3 Interventional Results available

Ketamine to Prevent PPD After Cesarean

NCT04227704
View directory record Official record
Conditions
Postpartum Depression
Interventions
Ketamine 50 MG/ML, Control
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers

NCT01482832
View directory record Official record
Conditions
Postpartum Depression
Interventions
Interpersonal therapy-based treatment
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
12 Years to 19 Years · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 23, 2026, 5:20 PM EDT
Recruiting Not applicable Interventional

Postpartum Care in the NICU (PeliCaN) Transitions

NCT06521398
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Premature Birth, Postpartum Depression, Postpartum Anxiety
Interventions
Doula Support
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
16 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 23, 2026, 5:20 PM EDT
Not listed Phase 2 Interventional

A Dyadic Approach to Perinatal Depression in Primary Care: Maternal Infant and Dyadic Care

NCT04998721
View directory record Official record
Conditions
Depression, Postpartum, Efficacy, Self, Anxiety
Interventions
Promoting First Relationships-Brief, Perinatal Collaborative Care
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 22, 2023 · Synced Oct 23, 2026, 5:20 PM EDT
Recruiting Not applicable Interventional

Parents and Babies Pilot

NCT07607613
View directory record Official record
Conditions
Perinatal Depression, Postpartum Depression (PPD)
Interventions
Parents and Babies Virtual Group Intervention, Parents and Babies Hybrid Group Intervention
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 23, 2026, 5:20 PM EDT
Recruiting Not applicable Interventional

In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression

NCT05766475
View directory record Official record
Conditions
Postpartum Depression
Interventions
ROSE Program: In Person, ROSE Program: Virtual
Behavioral
Lead sponsor
University of Denver
Other
Eligibility
18 Years and older · Female only
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional

Multidisciplinary Model of Nurse Midwife

NCT01935375
View directory record Official record
Conditions
Postpartum Depression
Interventions
CNM Interpersonal Psychotherapy, Treatment as Usual
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2015 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional

Family Nurture Intervention (FNI) in Neonatal Intensive Care Unit (NICU)

NCT01439269
View directory record Official record
Conditions
Premature Birth
Interventions
Family Nurture Intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
26 Weeks to 34 Weeks
Enrollment
394 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 23, 2026, 5:20 PM EDT
Completed Not applicable Interventional Results available

Personalized Integrated Chronotherapy for Perinatal Depression

NCT04364646
View directory record Official record
Conditions
Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation, Pregnancy Related, Sleep Disturbance
Interventions
Personalized Integrated Chronotherapy
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Glen Oaks, New York • Chapel Hill, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 23, 2026, 5:20 PM EDT