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ClinicalTrials.gov public records Last synced Nov 9, 2026, 5:43 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 186 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Postoperative Pain, Acute Clear all

Conditions: Post-operative Pain, Acute, Cesarean Section, Opioid Use Disorder, Opioids; Harmful Use
Interventions: Auricular percutaneous nerve field stimulator, Sham auricular percutaneous nerve field stimulator; Device
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years to 55 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Falls Church, Virginia

Conditions: Pain
Interventions: nicotine patch, placebo; Drug
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Pain, Postoperative
Interventions: IV acetaminophen, Oral acetaminophen, Morphine; Drug
Lead sponsor: Mallinckrodt; Industry
Eligibility: 50 Years to 90 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 2
States / cities: Pensacola, Florida • Columbus, Ohio

Conditions: Pain, Postoperative, Intrathoracic Procedure
Interventions: Atricure's crysoSPHERE probe, Standard of Care; Device · Procedure
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Acute Postoperative Pain, Dental Pain
Interventions: CYT-1010, Placebo; Drug
Lead sponsor: Cytogel Pharma, LLC; Industry
Eligibility: 18 Years to 45 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Pain, Post-operative, Third Molar, Oral Surgery, Pain, Acute
Interventions: Ketorolac, Oxycodone, Acetaminophen, Ibuprofen, Hydrocodone; Drug
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years to 44 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: San Diego, California

Conditions: Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder, Surgery
Interventions: Ketorolac, Dexmedetomidine, Morphine, Fentanyl; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 2 Years to 18 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Memphis, Tennessee

Conditions: Bunionectomy, Pain, Postoperative Pain, Acute Pain
Interventions: CG5503 IR, Morphine, Placebo; Drug
Lead sponsor: Grünenthal GmbH; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 291 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 6
States / cities: Pasadena, Maryland • Austin, Texas • Houston, Texas + 3 more

Conditions: Pain
Interventions: Acetaminophen/Naproxen Sodium Fixed Combination, Placebo; Drug
Lead sponsor: Johnson & Johnson Consumer Inc. (J&JCI); Industry
Eligibility: 16 Years to 65 Years
Enrollment: 143 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 4
States / cities: New Providence, New Jersey • Bellaire, Texas • Houston, Texas + 1 more

Conditions: Postoperative Pain
Interventions: Buprenorphine transdermal patch, Placebo BTDS; Drug
Lead sponsor: Purdue Pharma LP; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 5
States / cities: Phoenix, Arizona • San Clemente, California • Orlando, Florida + 2 more

Conditions: Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid, Postoperative Pain, Acute Pain
Interventions: Suzetrigine, Acetaminophen, oxycodone; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Postoperative Pain, Acute
Interventions: Active Pulsed Shortwave Treatment with BioElectronics Model 088, Sham Treatment; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: San Diego, California

Conditions: Cholecystitis, Acute, Cholelithiasis, Nausea, Postoperative, Vomiting, Postoperative, Pain, Postoperative
Interventions: Acupuncture; Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 64 Years
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pain, Postoperative, Thoracic, Acute Pain
Interventions: Liposomal Bupivacaine, Bupivacaine, 0.25%, Bupivacaine, 0.5%; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Acute Pain, Post Operative Pain
Interventions: Pharmacogenetic testing, Pharmacist note with genotype-guided analgesic recommendations, Pharmacist detailed note with genotype-guided recommendations per CPIC guidelines; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older · Female only
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Acute Pain
Interventions: Tapentadol oral solution 4 mg/mL, Tapentadol oral solution 20 mg/mL, Placebo; Drug · Other
Lead sponsor: Grünenthal GmbH; Industry
Eligibility: 1 Day to 18 Years
Enrollment: 216 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 13
States / cities: Little Rock, Arkansas • Stanford, California • Miami, Florida + 9 more

Conditions: Hip Arthropathy, Postoperative Pain, Acute, Pain, Postoperative
Interventions: Active bupivacaine 0.375% PENG block, Placebo normal saline PENG block; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Acute Blood Loss Anemia, Postoperative Pain, Pregnancy
Interventions: non-dissection of inferior rectus sheath, control; Procedure
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
Interventions: NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care; Device · Other
Lead sponsor: Jacques E. Chelly; Other
Eligibility: 18 Years and older
Enrollment: 274 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 3
States / cities: Pittsburgh, Pennsylvania

Conditions: Knee Arthroplasty, Total, Post Operative Pain, Acute, Opioid Consumption, Postoperative
Interventions: Suzetrigine, Opioid standard care pain medicine; Drug
Lead sponsor: Endeavor Health; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Skokie, Illinois

Conditions: Post-operative Pain
Interventions: IV Acetaminophen, Saline as placebo; Drug · Other
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Postoperative Pain
Interventions: Placebo comparator: VR googles and the non reality experience, Active Comparator: VR googles and the real VR program to enter act with and experience; Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 85 Years
Enrollment: 113 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Pain, Postoperative Pain, Pain, Acute
Interventions: MR-107A-01, Placebo; Drug
Lead sponsor: Mylan Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Acute Pain, Postoperative Pain, Acute
Interventions: 1.0% lidocaine with epinephrine (1:100,000); Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Search by objective public record fields.

Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimulator

Nicotine Patch as an Analgesic Adjuvant After Surgery

Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain

Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy

A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction

Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction

Opioid-Free Anesthetic for Tonsillectomy

A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy

A Study to Evaluate a Fixed Combination of Acetaminophen/Naproxen Sodium in Acute Postoperative Pain Following Bunionectomy

Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement

Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management

Pulsed Electromagnetic Fields for Postoperative Analgesia: A Randomized, Triple-Masked, Sham-Controlled Pilot Study

Acupuncture for Prevention of Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures

Pharmacogenetic-guided Choice of Post-surgery Analgesics

A Study to Look at Tapentadol Oral Solution in Children and Adolescents in Pain

Pericapsular Nerve Group Block (PENG) for Hip Surgery

Effect of Non-Dissection of the Inferior Rectus Sheath on Intraoperative Blood Loss

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery

IV Acetaminophen for Acute Post Operative Pain in C-Section Patients

Virtual Reality Distraction for Reduction

Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain

REctus Sheath Trial