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ClinicalTrials.gov public records Last synced Oct 20, 2026, 1:23 AM EDT

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Showing 73–96 of 1,834 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Postoperative Pain Clear all
Completed Phase 3 Interventional

An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries

NCT04785638
View directory record Official record
Conditions
Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy, Colectomy, Reduction Mammoplasty
Interventions
INL-001 (bupivacaine hydrochloride) implant
Combination Product
Lead sponsor
Innocoll
Industry
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
8
States / cities
Florence, Alabama • Sheffield, Alabama • Pasadena, California + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Oct 20, 2026, 1:23 AM EDT
Not listed Phase 3 Interventional

Randomized Trial of Intraoperative IV Versus Preoperative Oral Acetaminophen During Ambulatory Lumbar Discectomy

NCT04574778
View directory record Official record
Conditions
Pain, Postoperative, Spine Surgery
Interventions
Acetaminophen
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2024 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Not applicable Interventional

Qigong For PPSP In Breast Cancer Pain In Breast Cancer Survivors

NCT02848989
View directory record Official record
Conditions
Breast Cancer Surgery Pain, Breast Cancer, Stage 0-III Breast Cancer
Interventions
Qigong Mind-Body Exercise
Other
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain in Breast Surgery Intervention

NCT04058938
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative
Interventions
Educational handout instrument, Control
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2020 · Synced Oct 20, 2026, 1:23 AM EDT
Withdrawn Phase 3 Interventional

Intraoperative Transversus Abdominis Plane Block for Gynecologic Surgery (GYNTAP)

NCT02506855
View directory record Official record
Conditions
Postoperative Pain, Postoperative Nausea and Vomiting
Interventions
Ropivacaine, Placebo, Transversus Abdominis Plane Block
Drug · Other · Procedure
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 20, 2026, 1:23 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

NCT03119038
View directory record Official record
Conditions
Osteoarthritis, Degenerative Joint Disease
Interventions
Bupivicaine + epinephrine, Bupivacaine, Ropivacaine, Ketorolac, Clonidine Injection
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Oct 20, 2026, 1:23 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Pain With Differing Insufflation Pressures During Laparoscopic Hysterectomy

NCT06508814
View directory record Official record
Conditions
Post Operative Pain
Interventions
Lower Insufflation Pressure, Standard Insufflation Pressure
Procedure
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 23, 2024 · Synced Oct 20, 2026, 1:23 AM EDT
Suspended Phase 2Phase 3 Interventional

Safety of F14 Following Total Knee Replacement

NCT04860635
View directory record Official record
Conditions
Analgesia
Interventions
F14 (sustained release celecoxib)
Drug
Lead sponsor
Arthritis Innovation Corporation
Industry
Eligibility
45 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
2
States / cities
Denver, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 20, 2026, 1:23 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Dexamethasone Administered Via the Epidural Catheter as an Adjunct in Patients Undergoing Cesarean Delivery

NCT03877549
View directory record Official record
Conditions
Post Operative Pain
Interventions
Dexamethasone
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 55 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 26, 2023 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Not applicable Interventional Results available

Pilot Study of PEMF Therapy in Treatment of Post-operative Pain Following Total Knee Arthroplasty

NCT02211534
View directory record Official record
Conditions
Post-Operative Pain Following Total Knee Arthroplasty
Interventions
Pulsed Electromagnetic Field Device (Provant), Sham Pulsed Electromagnetic Field Device
Device
Lead sponsor
Regenesis Biomedical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
14
States / cities
Birmingham, Alabama • Phoenix, Arizona • El Cajon, California + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2017 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Not applicable Interventional Results available

Transcranial Electrostimulation and Obstructive Sleep Apnea Surgery

NCT03735004
View directory record Official record
Conditions
Transcranial Electrical Stimulation
Interventions
Transcranial electrostimulation (TES)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Not applicable Interventional

Controlled Study of Farabloc for Chronic Phantom Limb Pain Among Veteran Amputees

NCT00797849
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
Farabloc Limb Cover, Sham Limb Cover
Device
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Mar 14, 2012 · Synced Oct 20, 2026, 1:23 AM EDT
Withdrawn Not applicable Interventional

Pain After Insufflation for Robotic Sacrocolpopexy (PAIRS) Trial

NCT04858438
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Insufflation during surgery
Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 90 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Phase 3 Interventional

Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery

NCT00058357
View directory record Official record
Conditions
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
lidocaine, placebo
Drug · Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years to 120 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
159
States / cities
Scottsdale, Arizona • Washington D.C., District of Columbia • Jacksonville, Florida + 95 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2016 · Synced Oct 20, 2026, 1:23 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy

NCT06349772
View directory record Official record
Conditions
Post Operative Pain
Interventions
Zynrelef, Exparel
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 65 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 20, 2026, 1:23 AM EDT
Recruiting Phase 4 Interventional

Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine

NCT07316166
View directory record Official record
Conditions
Postoperative Pain Management
Interventions
Dexmedetomidine, Ropivacaine
Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Not applicable Interventional Results available

Pulsed Shortwave Therapy for Postoperative Analgesia

NCT05796583
View directory record Official record
Conditions
Postoperative Pain, Acute
Interventions
Active Pulsed Shortwave Treatment, Sham Treatment
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Phase 4 Interventional Results available

An Open-label Study of Hydromorphone Oral Solution in Subjects Aged 28 Days to 16 Years for Postoperative Pain

NCT00465647
View directory record Official record
Conditions
Postoperative Pain
Interventions
Hydromorphone
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
28 Days to 16 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
14
States / cities
Little Rock, Arkansas • Orange, California • Stanford, California + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2015 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy

NCT02452060
View directory record Official record
Conditions
Pain, Postoperative Depression
Interventions
Ketamine, Placebo Comparator
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Oct 20, 2026, 1:23 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Comparing Perioperative Outcomes in Pain Control

NCT05690282
View directory record Official record
Conditions
Post-operative Pain
Interventions
Multimodal Pain Management (Ibuprofen/Acetaminophen/GABAPentin/0.25%Bupivacaine)
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Oct 20, 2026, 1:23 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Methods for Recording Post Operative Pain

NCT06206148
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Given novel electronic pain recording device, Given Hand-written pain journal, Smartphone app
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Oct 20, 2026, 1:23 AM EDT
Recruiting Not applicable Interventional

Post-Surgery Wound Healing Tracking With MyHealthPal App

NCT07391735
View directory record Official record
Conditions
Wound Infection and Wound Healing
Interventions
MyHealthPal App
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 20, 2026, 1:23 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)

NCT05907213
View directory record Official record
Conditions
Pain, Postoperative, Depression, Postpartum
Interventions
Ketamine (Ketalar) Dose Level 1, Ketamine (Ketalar) Dose Level 2, Ketamine (Ketalar) Dose Level 3, Ketamine (Ketalar) Dose Level 4
Drug
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years and older · Female only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Oct 20, 2026, 1:23 AM EDT
Enrolling by invitation Not applicable Interventional

Prophylactic TBR on Phantom Limb Pain

NCT06956508
View directory record Official record
Conditions
Phantom Limb Pain After Amputation
Interventions
Targeted Brain Rehabilitation
Other
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
13 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 20, 2026, 1:23 AM EDT