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ClinicalTrials.gov public records Last synced Oct 21, 2026, 1:52 AM EDT

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Showing 97–120 of 1,111 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Postoperative Pain Control Clear all
Completed No phase listed Observational

Assessing the Efficacy of Intravenous Acetaminophen Versus the Oral Formulation for Perioperative Pain Treatment

NCT02216682
View directory record Official record
Conditions
Postoperative Pain
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 21, 2026, 1:52 AM EDT
Withdrawn Not applicable Interventional

Adductor Canal Nerve Block Following Total Knee Arthroplasty

NCT01939379
View directory record Official record
Conditions
Post-op Pain
Interventions
Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed., For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid

NCT01350024
View directory record Official record
Conditions
Blepharoptosis
Interventions
Frontal nerve block with 2% lidocaine with 1:100,000 dilution of epinephrine, Subconjunctival injection of 2% lidocaine with 1:100,000 dilution with epinephrine
Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 100 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 21, 2026, 1:52 AM EDT
Withdrawn Phase 4 Interventional

Pectoral Nerve Blockade in Mastectomy

NCT01943240
View directory record Official record
Conditions
Postoperative Pain, Breast Cancer
Interventions
Paravertebral nerve block: 4 mL ropivacaine 0.5% at each of six levels, 10 cc of 0.375% ropivacaine pectoral nerve block
Drug
Lead sponsor
Timothy R Petersen
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 21, 2026, 1:52 AM EDT
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

Bupivacaine Hydrochloride for Pain Control in Cutaneous Surgery

NCT04260854
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine Hydrochloride, Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
19 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 21, 2026, 1:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cesarean Postoperative Pain Satisfaction

NCT00922142
View directory record Official record
Conditions
Cesarean
Interventions
Not listed
Lead sponsor
Saint Elizabeth Regional Medical Center
Other
Eligibility
14 Years to 40 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jul 20, 2011 · Synced Oct 21, 2026, 1:52 AM EDT
Not yet recruiting Not applicable Interventional

Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures

NCT05318729
View directory record Official record
Conditions
Distal Radius Fracture, Radius Fracture Distal, Radius; Fracture, Lower or Distal End, Postoperative Pain
Interventions
Vibration tool
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation and Pain

NCT02793817
View directory record Official record
Conditions
Post Surgical Ocular Inflammation and Pain
Interventions
KPI-121 1% Ophthalmic Suspension dosed BID, Vehicle of KPI-121 Ophthalmic Suspension dosed BID
Drug
Lead sponsor
Kala Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
35
States / cities
Chandler, Arizona • Phoenix, Arizona • Artesia, California + 32 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Study of Acetaminophen for Post Surgical Dental Pain

NCT04018612
View directory record Official record
Conditions
Pain, Postoperative, Dental Pain
Interventions
Acetaminophen, Placebo
Drug · Other
Lead sponsor
Nevakar, Inc.
Industry
Eligibility
17 Years to 55 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 29, 2022 · Synced Oct 21, 2026, 1:52 AM EDT
Not listed Phase 4 Interventional

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

NCT05109312
View directory record Official record
Conditions
Analgesia
Interventions
Bupivacaine Hydrochloride, HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
7
States / cities
Little Rock, Arkansas • Sarasota, Florida • Tulsa, Oklahoma + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 21, 2026, 1:52 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

NCT06576830
View directory record Official record
Conditions
Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea, Sleep-Disordered Breathing
Interventions
Methadone, Fentanyl/Hydromorphone
Drug
Lead sponsor
Duke University
Other
Eligibility
3 Years to 17 Years
Enrollment
440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 1 Interventional

The Effect Of An Anesthetic Procedure On Post Operative Pain Management In Carpal Tunnel Release

NCT03729375
View directory record Official record
Conditions
Pain, Postoperative, Carpal Tunnel Syndrome
Interventions
10cc injection of bupivacaine, 20cc injection of bupivacaine
Drug
Lead sponsor
University of South Florida
Other
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Oct 21, 2026, 1:52 AM EDT
Completed No phase listed Observational

Caudal Epidural Block for Postoperative Analgesia in Adolescents Following Major Hip Surgery.

NCT01930201
View directory record Official record
Conditions
Major Orthopedic Hip Surgery
Interventions
Caudal epidural block, General anesthesia
Procedure · Other
Lead sponsor
David P. Martin
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 29, 2014 · Synced Oct 21, 2026, 1:52 AM EDT
Terminated Phase 4 Interventional Results available

Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries

NCT03927911
View directory record Official record
Conditions
Postoperative Pain Management
Interventions
EXPAREL and Bupivacaine, Standard of Care
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
12
States / cities
New Haven, Connecticut • Boca Raton, Florida • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Oct 21, 2026, 1:52 AM EDT
Terminated Phase 3 Interventional

Effect of Music on Pain and Anxiety After Surgery

NCT01409044
View directory record Official record
Conditions
Postop Adult ICU Patients
Interventions
Music
Other
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 99 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2017 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Not applicable Interventional

Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery

NCT05011084
View directory record Official record
Conditions
Cryotherapy Effect, Compression, Postoperative Pain Management
Interventions
Game Ready Cryotherapy with Compression Group, Control Cryotherapy Group
Device · Other
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Opioid Analgesic Reduction Study (OARS) - Pilot

NCT05283499
View directory record Official record
Conditions
Post Operative Pain
Interventions
OPIOID, NON-OPIOID
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 99 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
5
States / cities
Chicago, Illinois • Baltimore, Maryland • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 3 Interventional Results available

Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)

NCT02480621
View directory record Official record
Conditions
Ankle Fracture
Interventions
Liposomal Bupivacaine with Bupivacaine
Drug
Lead sponsor
Jamaica Hospital Medical Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2017 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 3 Interventional Results available

Co-crystal E-58425 vs Tramadol and Celecoxib for Moderate to Severe Acute Pain After Bunionectomy. Phase III Clinical Trial.

NCT03108482
View directory record Official record
Conditions
Acute Post-surgical Pain
Interventions
Co-crystal E-58425 (Tramadol/Celecoxib), Tramadol (Ultram®), Celecoxib (Celebrex®), Placebo
Drug
Lead sponsor
Esteve Pharmaceuticals, S.A.
Industry
Eligibility
18 Years and older
Enrollment
637 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
5
States / cities
Phoenix, Arizona • Anaheim, California • Pasadena, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2019 · Synced Oct 21, 2026, 1:52 AM EDT
Recruiting Phase 4 Interventional

Ketamine for Post-operative Analgesia in Hemorrhoidectomy

NCT04248205
View directory record Official record
Conditions
Hemorrhoids
Interventions
Ketamine
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 3 Interventional

Study of Acetaminophen (ACM) in Post-operative Dental Pain

NCT02735122
View directory record Official record
Conditions
Post Operative Dental Pain
Interventions
acetaminophen Tablet, acetaminophen Caplet, ibuprofen Liquid-filled capsule, Placebo Tablet, Placebo Caplet, Placebo Liquid-filled capsule
Drug
Lead sponsor
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Industry
Eligibility
17 Years to 50 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 4 Interventional Results available

Regional Block for Postoperative Free Flap Care

NCT04080739
View directory record Official record
Conditions
Pain Management
Interventions
ropivicaine 0.2%
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 6, 2023 · Synced Oct 21, 2026, 1:52 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy

NCT03875664
View directory record Official record
Conditions
Postoperative Pain
Interventions
Liposomal bupivacaine, Placebo - injection
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 21, 2026, 1:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

iPAWS: Improving Pain Management After Wisdom Tooth Extraction Surgery

NCT07731295
View directory record Official record
Conditions
Pain, Postoperative, Substance Use
Interventions
iPAWS, Educational Materials
Behavioral · Other
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 21, 2026, 1:52 AM EDT