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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Postpartum Depressive Mood Clear all
Recruiting Not applicable Interventional

Informing Implementation of a Circadian-Focused Intervention for Postpartum Depression

NCT07766161
View directory record Official record
Conditions
Postpartum Depression (PPD)
Interventions
Light therapy
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Phase 2 Interventional Results available

A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

NCT03460756
View directory record Official record
Conditions
Depressive Disorder, Depression, Depression, Postpartum, Behavioral Symptoms, Mood Disorders, Mental Disorder, Pregnancy Complications, Postpartum Blues, PPD, Postpartum Disorder
Interventions
Ganaxolone, Placebo
Drug
Lead sponsor
Marinus Pharmaceuticals
Industry
Eligibility
18 Years to 48 Years · Female only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
33
States / cities
Glendale, California • Lemon Grove, California • Long Beach, California + 29 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2023 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Measuring and Reducing Excessive Infant Crying

NCT01217658
View directory record Official record
Conditions
Infant Colic, Postpartum Depression
Interventions
The Happiest Baby on The Block, AAP Infant Colic counseling
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
3 Weeks to 5 Weeks
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2015 · Synced Sep 28, 2026, 6:57 AM EDT
Completed No phase listed Observational

Relationship Between Postpartum Mood Disorders and Delivery Experience

NCT03004872
View directory record Official record
Conditions
Postpartum Period, Depression, Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Early Versus Traditional Follow-Up on Breastfeeding Rates at 6 Months

NCT02221895
View directory record Official record
Conditions
Pregnancy, Breastfeeding, Contraception, Cervical Cancer, Postpartum Depression
Interventions
Postpartum follow up appointment 2-3 weeks after delivery, Postpartum follow up 6-8wk after delivery
Other
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 50 Years · Female only
Enrollment
344 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Sep 28, 2026, 6:57 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Mobile Application in the Management of Mild to Moderate Postpartum Depression (PPD)

NCT05077644
View directory record Official record
Conditions
Post-partum Depression
Interventions
Stella (TM) Mobile Application
Device
Lead sponsor
Curio Digital Therapeutics, Inc.
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Depression Prevention for Pregnant Women on Public Assistance

NCT00601757
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
The Postpartum Prevention Program (PPP), Enhanced care as usual (ECU)
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
207 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
3
States / cities
Providence, Rhode Island • Woonsocket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 30, 2014 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Phase 2 Interventional

RE104 Safety and Efficacy Study in Postpartum Depression

NCT06342310
View directory record Official record
Conditions
Postpartum Depression
Interventions
RE104 for Injection
Drug
Lead sponsor
Reunion Neuroscience Inc
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
38
States / cities
Birmingham, Alabama • Tucson, Arizona • Santa Monica, California + 31 more
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional

A Postpartum Adaptation Study of the Connecting and Reflecting Experience Parenting Program

NCT06042166
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Parenting Stress, Parent Child Relationships
Interventions
Connecting and Reflecting Experience (CARE) Program
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional Results available

Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk

NCT06276647
View directory record Official record
Conditions
Maternal Behavior, Postpartum Depression
Interventions
HOME
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depressive Relapse/Recurrence

NCT02387424
View directory record Official record
Conditions
Postpartum Depression, Pregnancy, Depression
Interventions
MBCT-PD, OAR
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
4
States / cities
Boulder, Colorado • Denver, Colorado • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Sep 28, 2026, 6:57 AM EDT
Recruiting No phase listed Observational

A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone

NCT07398469
View directory record Official record
Conditions
Postpartum Depression
Interventions
Zuranolone
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional Results available

Mommy-Baby Treatment for Perinatal Depression

NCT01744041
View directory record Official record
Conditions
Depressive Disorder, Major, Postpartum Depression
Interventions
Dyadic Interpersonal Psychotherapy, Enhanced Treatment as Usual
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression

NCT02978326
View directory record Official record
Conditions
Postpartum Depression
Interventions
SAGE-217 15/20 mg Oral Solution, Placebo, SAGE 217 30 mg Capsules
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
27
States / cities
Little Rock, Arkansas • Beverly Hills, California • Oceanside, California + 24 more
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Northwell Health Visits: A Family Connects Pilot Implementation at Northwell Health

NCT03887910
View directory record Official record
Conditions
Unspecified Child Maltreatment, Suspected, Unspecified Child Maltreatment, Confirmed, Postpartum Depression
Interventions
Enhanced Intervention, Intervention
Other
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
840 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Childbirth-Related PTSD With Expressive Writing

NCT05662423
View directory record Official record
Conditions
PTSD (Childbirth-Related)
Interventions
Expressive Writing about Childbirth, Neutral Writing
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional Results available

The Effects of Light Therapy on Circadian Rhythms, Sleep, and Mood in Postpartum Depression

NCT02769858
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Light therapy
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Effects of Interpersonal Psychotherapy on Depression During and After Pregnancy

NCT00380419
View directory record Official record
Conditions
Depression, Anxiety Disorders
Interventions
Interpersonal Psychotherapy (IPT)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Sep 28, 2026, 6:57 AM EDT
Active, not recruiting Not applicable Interventional

Living Healthy for Moms RCT

NCT06666400
View directory record Official record
Conditions
Postpartum Depression (PPD), Cardiac Event
Interventions
LHMoms Intervention, No intervention
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
4
States / cities
Brooklyn, New York • Jamaica, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Intervention for IPV-exposed Pregnant Women

NCT04068662
View directory record Official record
Conditions
Postpartum Depression, Posttraumatic Stress Disorder, Infant Behavior, Violence, Parenting
Interventions
Pregnant Moms' Empowerment Program, Nondirective Support Group
Behavioral
Lead sponsor
University of Notre Dame
Other
Eligibility
3 Months to 55 Years · Female only
Enrollment
424 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Notre Dame, Indiana • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Meditation for NICU Moms

NCT03574766
View directory record Official record
Conditions
Breast Feeding, Premature Birth, Stress, Depression, Postpartum, Anxiety, Self Efficacy, Behavior, Maternal, Insufficient Lactation
Interventions
Meditation
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Richmond Heights, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Prevention of Postpartum Depression in Low-Income Women

NCT00053651
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Survival Skills for Moms with New Babies
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2001
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 21, 2013 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Madres Para la Salud (Mothers for Health)

NCT01908959
View directory record Official record
Conditions
Overweight and Obesity, Depression, Postpartum, Mother (Person)
Interventions
Madres para la Salud
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
177 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 25, 2013 · Synced Sep 28, 2026, 6:57 AM EDT
Completed Not applicable Interventional

Baby2Home (B2H) Mobile Health Application

NCT05595486
View directory record Official record
Conditions
COVID-19 Pandemic, Health Knowledge, Attitudes, Practice, Perinatal Depression, Mental Health Wellness, Post Partum Depression
Interventions
Baby2Home Mobile Application
Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
642 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Sep 28, 2026, 6:57 AM EDT