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Conditions: Hypertension, Pregnancy-Induced
Interventions: Oral furosemide, Placebo Oral Tablet; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 384 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Hypertensive Disorder
Interventions: Blood pressure cuff; Device
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years to 54 Years · Female only
Enrollment: 421 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Hypertension, Pregnancy-Induced
Interventions: Acetaminophen, Ibuprofen; Drug
Lead sponsor: MemorialCare Health System; Other
Eligibility: 18 Years and older · Female only
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Long Beach, California

Conditions: Hypertension
Interventions: Acetaminophen, NSAID; Drug
Lead sponsor: St. Louis University; Other
Eligibility: 14 Years to 50 Years · Female only
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Preeclampsia, Hypertensive Disorder of Pregnancy, Toxemia, Pregnancy Complications, Hypertension, Pregnancy-Induced, Hypertension, Obesity, Overweight, Nutrition Disorders, Vascular Diseases, Cardiovascular Diseases, Pre-Eclampsia, Eclampsia, Gestational Hypertension
Interventions: Heart Health Doula Intervention Program, Usual Care; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older · Female only
Enrollment: 454 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Preeclampsia Severe, Pre-Eclampsia, Preeclampsia, Preeclampsia Second Trimester, Preeclampsia Complicating Childbirth, Preeclampsia Puerperium, Preterm
Interventions: Metformin, Esomeprazole; Drug
Lead sponsor: Christiana Care Health Services; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Pre-Eclampsia; Complicating Pregnancy, Gestational Hypertension
Interventions: Video, Text Reminder, Blood pressure threshold; Other
Lead sponsor: Ochsner Health System; Other
Eligibility: 18 Years and older · Female only
Enrollment: 296 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Hypertension in Pregnancy
Interventions: Enalapril 10mg QD, Nifedipine 30mg XL BID; Drug
Lead sponsor: Nebraska Methodist Health System; Other
Eligibility: 19 Years and older · Female only
Enrollment: 850 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Pregnancy, Preeclampsia
Interventions: abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery); Drug
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Pre-Eclampsia, Pregnancy Induced Hypertension
Interventions: Not listed
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 1,100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: San Diego, California

Conditions: Preeclampsia, Preeclampsia Postpartum, Preeclampsia Severe or Mild
Interventions: Butterfly iQ3 ultrasound system for determination of postpartum volume status, Oral furosemide, Intravenous furosemide; Diagnostic Test · Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older · Female only
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Orange, California

Conditions: Preeclampsia
Interventions: Compound 21, Angiotensin II; Drug
Lead sponsor: Anna Stanhewicz, PhD; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Gestational Diabetes Mellitus, Hypertension in Pregnancy, Dysglycemia
Interventions: OB Provider Clinical Decision Support (CDS), Patient Education (OB Visit), Text messaging, Patient Outreach, Primary Care Provider Clinical Decision Support (CDS), Patient Education (Primary Care Visit); Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: Chicago, Illinois

Conditions: Preeclampsia, Gestational Hypertension, Hypertension, Obesity, Overweight and Obesity, Pregnancy Complications, Pregnancy Toxemia, Postpartum Preeclampsia
Interventions: Home Blood Pressure Monitoring, Heart Health 4 New Moms, Usual care; Behavioral · Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older · Female only
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Hypertension
Interventions: Pulsewave oscillometric wrist cuff blood pressure monitor; Device
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2016
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Postpartum Haemorrhage (PPH), PPH, Postpartum Hemorrhage (Primary)
Interventions: Alma System; Device
Lead sponsor: ResQ Medical Ltd; Other
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Hypertension, Pregnancy-Induced, Hypertension, Postpartum Preeclampsia, Postpartum Complication, Postpartum Pre-Eclampsia, Cardiovascular Diseases, Cardiovascular Morbidity, Morbidity;Perinatal
Interventions: BP Watch; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
Interventions: Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs; Drug · Other
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older · Female only
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Preeclampsia, Preeclampsia Severe, Preeclampsia Mild, Preeclampsia Postpartum
Interventions: Illustration based application, Text based application; Other
Lead sponsor: MemorialCare Health System; Other
Eligibility: 18 Years and older · Female only
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Long Beach, California

Conditions: Blood Pressure, Hypertension, Pregnancy Related, Health Equity
Interventions: PDSA Cycles; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Hypertension in Pregnancy, Postpartum Preeclampsia, Postpartum Complication
Interventions: RI-SPHERES, Standard self-measured blood pressure program; Behavioral
Lead sponsor: Women and Infants Hospital of Rhode Island; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 1,536 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 5
States / cities: Newport, Rhode Island • Providence, Rhode Island • Wakefield, Rhode Island + 2 more

Conditions: Severe Postpartum Hypertension
Interventions: Labetalol, Nifedipine; Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 100 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Gestational Hypertension, Hypertension in Pregnancy, Pre-Eclampsia, Superimposed Pre-Eclampsia, Cardiovascular Complication
Interventions: Placebo, Dapagliflozin 10mg Tab; Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Preeclampsia
Interventions: Oxytocin, Placebo; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 13 Years to 45 Years · Female only
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Aurora, Colorado

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Furosemide for Accelerated Recovery of Blood Pressure Postpartum

Use of a Cloud-connected Remote Blood Pressure Monitoring Program During the Postpartum Period for Hypertensive Women

Hypertension In Postpartum Preeclampsia Study

NSAID Use in Postpartum Hypertensive Women

Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial

Metformin and Esomeprazole in Preterm Pre-eclampsia

Remote Postpartum Blood Pressure Monitoring and Cardiovascular Education

Postpartum Evaluation of Nifedipine and Enalapril for Hypertension

Abbreviated MgSO4 Therapy in Post-partum Preeclampsia

Multi-Omics for Maternal Health After Preeclampsia

Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound

Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia

Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)

Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia

Validation of Pulsewave Blood Pressure Monitor in Hypertensive and Normotensive Pregnant and Postpartum Women

EVE TRIAL , ALMA SYSTAM

Wearables to Define Postpartum Blood Pressure Trajectories and Facilitate Evidence-based Monitoring Guidelines

Postpartum NSAIDS and Maternal Hypertension

Preeclampsia Educational Program Study (PrEPS)

Community-based Implementation of Adapted STAC

Rhode Island - Statewide Postpartum Hypertension Remote Surveillance

Oral Nifedipine Versus Oral Labetalol

A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk Reduction in the Postpartum Period of Hypertensive Pregnancies (HP)

Postpartum Hemorrhage Prevention in Patients With Preeclampsia (PHP3 Study)