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Showing 1–24 of 281 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Postpartum Psychiatric Disorders Clear all
Completed Not applicable Interventional

Nurtured in Nature

NCT04146025
View directory record Official record
Conditions
Postpartum Depression, Pregnancy Related, Environmental Exposure
Interventions
Nature Coach Intervention
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Phase 4 Interventional Results available

Escitalopram (Lexapro) for the Treatment of Postpartum Depression

NCT00833469
View directory record Official record
Conditions
Postpartum Depression
Interventions
Escitalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2014 · Synced Sep 15, 2026, 5:46 PM EDT
Recruiting No phase listed Observational

External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

NCT06788977
View directory record Official record
Conditions
Pregnancy, Migraine, Headache, Postpartum, Depression, Anxiety
Interventions
external Trigeminal Nerve Stimulation
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 44 Years · Female only
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Darien, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 15, 2026, 5:46 PM EDT
Completed No phase listed Observational

Pregnant Women Taking Lamictal for Bipolar Disorder

NCT01996293
View directory record Official record
Conditions
Bipolar Disorder
Interventions
lamotrigine
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Phase 2 Interventional Results available

Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression

NCT02285504
View directory record Official record
Conditions
Postpartum Depression
Interventions
SAGE-547
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Not applicable Interventional

Insomnia and Rumination in Late Pregnancy and the Risk for Postpartum Depression

NCT03596879
View directory record Official record
Conditions
Insomnia, Post Partum Depression
Interventions
dCBTI, Sleep Education
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Phase 2 Interventional

A Study of BRII-296 in Adults With Severe Postpartum Depression (PPD)

NCT06057012
View directory record Official record
Conditions
Severe Postpartum Depression
Interventions
BRII-296, Depo Medrol
Drug
Lead sponsor
Brii Biosciences Limited
Industry
Eligibility
18 Years to 45 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
11
States / cities
Sherman Oaks, California • Torrance, California • Boynton Beach, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 15, 2026, 5:46 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

New Mothers Alpha-Stim

NCT04770181
View directory record Official record
Conditions
Anxiety, Depression, Insomnia, Sleep Quality
Interventions
Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator)
Device
Lead sponsor
Christina Murphey, RN, PhD
Individual
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Austin, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Sep 15, 2026, 5:46 PM EDT
Not yet recruiting Not applicable Interventional

The Goal is to Examine the Impact of Doula-coordinated, Midwife-delivered Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission.

NCT07787845
View directory record Official record
Conditions
Doula Support, Postpartum, Postpartum Anaemia, Postpartum Depression (PPD)
Interventions
Doula-coordinated, Midwife-delivered postpartum care
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years and older · Female only
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Not applicable Interventional

Efficacy of Yoga for Postpartum Depression

NCT02213601
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Yoga
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Not applicable Interventional

Effects of Interpersonal Psychotherapy on Depression During and After Pregnancy

NCT00380419
View directory record Official record
Conditions
Depression, Anxiety Disorders
Interventions
Interpersonal Psychotherapy (IPT)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Phase 2 Interventional

A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression

NCT06285916
View directory record Official record
Conditions
Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression, Post-Natal Depression
Interventions
NORA520 Dose 1, NORA520 Dose 2, Placebo
Drug
Lead sponsor
TWi Biotechnology, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
18
States / cities
Bentonville, Arkansas • Anaheim, California • Canoga Park, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 15, 2026, 5:46 PM EDT
Terminated Not applicable Interventional

Family Nurture Intervention in the CHoNJ NICU

NCT02352142
View directory record Official record
Conditions
Premature Birth
Interventions
Full Term EEG, Facilitated Infant Care
Other · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
26 Weeks to 42 Weeks
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Newark, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2016 · Synced Sep 15, 2026, 5:46 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biological Triggers of Depression in Pregnancy

NCT02566980
View directory record Official record
Conditions
Depression and Suicide, Mood Disorders, Other Perinatal Conditions
Interventions
Not listed
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older · Female only
Enrollment
209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
3
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 27, 2018 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Progesterone & Postpartum Relapse to Smoking

NCT01798394
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Use Disorder
Interventions
Progesterone, Placebo
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 8, 2017 · Synced Sep 15, 2026, 5:46 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Perinatal Emotion and Relationships Longitudinal Study

NCT03027037
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Not listed
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 30, 2020 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Phase 2Phase 3 Interventional

Recovery Housing For Drug Dependent Pregnant Women

NCT00497302
View directory record Official record
Conditions
Drug Addiction
Interventions
RBT, usual care
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2013 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Web-based Nursing Intervention in the Reduction of Postpartum Depression and Parenting Stress.

NCT02843022
View directory record Official record
Conditions
Depression, Postpartum
Interventions
standardized electronic messages, nurse phone call if requested, Staff nurse phone follow-up
Behavioral
Lead sponsor
Saint Anselm College
Other
Eligibility
18 Years and older · Female only
Enrollment
683 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 22, 2018 · Synced Sep 15, 2026, 5:46 PM EDT
Terminated Phase 2 Interventional Results available

Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression

NCT04011592
View directory record Official record
Conditions
Post Partum Depression
Interventions
Ketamine 0.5 mg/kg, Ketamine 0.2 mg/kg
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 18, 2021 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Virtual Group Psychoeducational Discussions With Spanish-Speaking Mothers of Infants in Pediatric Primary Care

NCT05423093
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety
Interventions
Single-Session Virtual Group Psychoeducational Session about Postpartum Depression
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
16 Years to 99 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood

NCT03646539
View directory record Official record
Conditions
Cognitive Therapy, Depression, Postpartum, Mental Health, Depression, Depressive Disorder, Anxiety, Telemedicine
Interventions
Use of smartphone application (app), Treatment as usual
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
201 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Sep 15, 2026, 5:46 PM EDT
Completed Phase 4 Interventional Results available

A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting

NCT05059600
View directory record Official record
Conditions
Postpartum Depression
Interventions
ZULRESSO®
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
6
States / cities
Culver City, California • Miramar, Florida • Pompano Beach, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Sep 15, 2026, 5:46 PM EDT
Recruiting Not applicable Interventional

Postpartum Care in the NICU (PeliCaN) Transitions

NCT06521398
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Premature Birth, Postpartum Depression, Postpartum Anxiety
Interventions
Doula Support
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
16 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 15, 2026, 5:46 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Parenting Skills Group for Mothers With Postpartum Depression

NCT05772897
View directory record Official record
Conditions
Postpartum Depression
Interventions
Circle of Security Parenting program
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2035
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Sep 15, 2026, 5:46 PM EDT