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ClinicalTrials.gov public records Last synced Oct 3, 2026, 5:51 AM EDT

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Showing 241–264 of 1,253 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Posttraumatic Stress Disorder PTSD Clear all
Completed Phase 4 Interventional Results available

Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy

NCT01087736
View directory record Official record
Conditions
PTSD, Alcohol Abuse, Alcoholism
Interventions
Topiramate, Placebo administration
Drug · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Phase 1 Interventional

Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)

NCT00760734
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Post Concussion Syndrome, Post Traumatic Stress Disorder, Chronic Post Traumatic Stress Disorder
Interventions
Low pressure hyperbaric oxygen therapy
Drug
Lead sponsor
Paul G. Harch, M.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 3, 2026, 5:51 AM EDT
Recruiting Not applicable Interventional

Neural Connectivity During Therapy for Adolescent PTSD

NCT05423444
View directory record Official record
Conditions
PTSD, Adolescent, Psychological Trauma
Interventions
TF-CBT, TAU
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
12 Years to 17 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Oct 3, 2026, 5:51 AM EDT
Terminated Not applicable Interventional

Trial of Art Therapy During Cognitive Processing Therapy for PTSD

NCT02610049
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Stress Disorder, Post-Traumatic
Interventions
Cognitive Processing therapy, Art + CPT, CPT + Art Therapy
Behavioral
Lead sponsor
Hampton VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Hampton, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 9, 2017 · Synced Oct 3, 2026, 5:51 AM EDT
Terminated Phase 4 Interventional Results available

PTSD Prevention Study Examining the Efficacy of Sertraline in Burn Victims

NCT02520726
View directory record Official record
Conditions
Post-traumatic Stress Disorder
Interventions
Sertraline, Placebo oral capsule
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 10, 2018 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Implementation of Prolonged Exposure in the Military

NCT02982538
View directory record Official record
Conditions
PTSD
Interventions
Extended Training in Prolonged Exposure Therapy for PTSD, Standard Training in Prolonged Exposure Therapy for PTSD
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2021
U.S. locations
3
States / cities
Colorado Springs, Colorado • Fort Campbell North, Kentucky • El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 3, 2026, 5:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Efficacy of a Multi-level School Intervention for LGBTQ Youth

NCT05541406
View directory record Official record
Conditions
Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior, Sexual Minority Stress, Suicidality, Substance Use, Bullying, Harassment
Interventions
Proud & Empowered, Control Group
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 20 Years
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
23
States / cities
El Monte, California • Glendale, California • Inglewood, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Phase 3 Interventional

Epigenetics and MDMA-Assisted Psychotherapy for PTSD

NCT06189027
View directory record Official record
Conditions
PTSD
Interventions
MDMA, Psychotherapy
Drug · Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Safety & Efficacy Study Using Topiramate in Posttraumatic Stress Disorder

NCT00204386
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Topiramate
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 64 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 30, 2007 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Phase 2 Interventional

Probiotic (LGG) for Veterans With PTSD

NCT04150380
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Inflammation
Interventions
Lactobacillus rhamnosus GG (LGG; ATCC strain 53103; CRMTS #11272; PTS #3766), Placebo
Biological · Other
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 60 Years
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Not applicable Interventional

Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians

NCT02124694
View directory record Official record
Conditions
Depression, Grief, PTSD, Interpersonal Relations
Interventions
HTUG
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Phase 2 Interventional Results available

CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders

NCT02500602
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Alcohol Use Disorders
Interventions
doxazosin, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Oct 3, 2026, 5:51 AM EDT
Not yet recruiting Not applicable Interventional

Cognitive Processing Therapy for Posttraumatic Stress Disorder and Co-occurring Lived Experience Stress

NCT07714083
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Standard CPT, CPT-LEAP
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 3, 2026, 5:51 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Relaxation Response Training for PTSD Prevention in US Military Personnel

NCT01725854
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Relaxation Response training
Behavioral
Lead sponsor
William Beaumont Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2016 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Not applicable Interventional

Efficacy Trial of Stress Check-Up

NCT03423394
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Motivational Enhancement Therapy, Treatment as Usual
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Oct 3, 2026, 5:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Outcomes Following Surf Therapy

NCT02857751
View directory record Official record
Conditions
Depression, Posttraumatic Stress Disorder
Interventions
Surf therapy
Behavioral
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Oct 3, 2026, 5:51 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Senseye's OBCI Diagnostic Tool for PTSD

NCT05372523
View directory record Official record
Conditions
PTSD
Interventions
CAPS-5 Assessment, Senseye OBCI
Diagnostic Test
Lead sponsor
Senseye, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Sylmar, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 3, 2026, 5:51 AM EDT
Withdrawn Phase 1 Interventional

The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.

NCT03752918
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
MDMA, Niacin
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Not applicable Interventional Results available

Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)

NCT01477762
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 3, 2026, 5:51 AM EDT
Recruiting Phase 2 Interventional

Dose Optimization of MDMA-Assisted Therapy for PTSD

NCT06418178
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Midomafetamine, Psychotherapy
Drug · Behavioral
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Not applicable Interventional Results available

Neuromodulation for Post-Traumatic Stress Disorder

NCT02377089
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Trigeminal Nerve Stimulation, Placebo
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2022 · Synced Oct 3, 2026, 5:51 AM EDT
Completed No phase listed Observational Results available

Cognition and Psychotherapy in PTSD

NCT03641924
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2025 · Synced Oct 3, 2026, 5:51 AM EDT
Active, not recruiting Not applicable Interventional

Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD

NCT05478759
View directory record Official record
Conditions
Brain Injury, Post Traumatic Stress Disorder
Interventions
Multimodal affect recognition training, Attention Training, Brain Health Workshop, National Geographic Movies
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
25 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 3, 2026, 5:51 AM EDT
Completed Phase 4 Interventional

Prazosin Treatment for Combat Trauma PTSD (Post-Traumatic Stress Disorder) Nightmares and Sleep Disturbance

NCT00108420
View directory record Official record
Conditions
Stress Disorder, Post-Traumatic
Interventions
Prazosin
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 3, 2026, 5:51 AM EDT