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ClinicalTrials.gov public records Last synced Oct 4, 2026, 9:59 AM EDT

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Showing 49–72 of 162 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Posttraumatic Stress Symptom Clear all
Completed Not applicable Interventional Results available

Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)

NCT02248675
View directory record Official record
Conditions
Insomnia, Depression, Posttraumatic Stress Disorder, Suicidal Ideation
Interventions
CBT-I, TAU
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2017 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)

NCT00990106
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Combat Disorders, Sleep Disorders
Interventions
prazosin hydrochloride, placebo
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 23, 2018 · Synced Oct 4, 2026, 9:59 AM EDT
Recruiting Not applicable Interventional

Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

NCT05751473
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Prolonged Exposure for Primary Care (PE-PC), EAP Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
410 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
14
States / cities
San Diego, California • Carrollton, Georgia • Ann Arbor, Michigan + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Online Therapy for Posttraumatic Stress Symptoms in WTC Responders and Survivors

NCT03154151
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Online Cognitive-Behavioral Therapy, Online Supportive Therapy
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
4
States / cities
New Haven, Connecticut • Boston, Massachusetts • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Oct 4, 2026, 9:59 AM EDT
Terminated Phase 4 Interventional Results available

Predicting SSRI Efficacy in Veterans With PTSD

NCT04183205
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions
LDAEP, Placebo, sertraline
Diagnostic Test · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Boston, Massachusetts • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

CBT Texts for PTSD & Hazardous Drinking (Project Better)

NCT05372042
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Alcohol Use
Interventions
CBT Text Messages
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Oct 4, 2026, 9:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder

NCT00025974
View directory record Official record
Conditions
Panic Disorder, Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Neuromodulatory Treatments for Pain Management in TBI

NCT03418129
View directory record Official record
Conditions
Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder
Interventions
Mindfulness, Neurofeedback, Relaxation
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Telemedicine for Improved Delivery of Psychosocial Treatments for Post Traumatic Stress Disorder

NCT01158001
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Depression, Anxiety
Interventions
Prolonged exposure therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 24, 2015 · Synced Oct 4, 2026, 9:59 AM EDT
Withdrawn Phase 2 Interventional

Trifecta Research Study

NCT06810765
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Trauma, Brain Injuries
Interventions
Hormone Replacement Therapy (HRT), Magnetic Resonance Therapy (MeRT), ibogaine with magnesium treatment, 5-MeO-DMT
Other · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 4, 2026, 9:59 AM EDT
Recruiting Phase 2Phase 3 Interventional

The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms

NCT07756723
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions
Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy
Behavioral
Lead sponsor
Coatesville VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Coatesville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Breathwork Intervention for Posttraumatic Stress

NCT07129278
View directory record Official record
Conditions
PTSD
Interventions
Breathwork
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Branford, Connecticut • Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

PCORI-1306-02918 Evaluation of Parent-based Programs to Support Children After Traumatic Injury

NCT02323204
View directory record Official record
Conditions
Psychological Trauma, Depression, Coping
Interventions
Link for Injured Kids, So you've been in an accident
Behavioral · Other
Lead sponsor
Marizen Ramirez
Other
Eligibility
10 Years to 17 Years
Enrollment
628 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
4
States / cities
Des Moines, Iowa • Iowa City, Iowa • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Oct 4, 2026, 9:59 AM EDT
Withdrawn Phase 1Phase 2 Interventional

TTI-0102 for Veterans With TBI

NCT04262895
View directory record Official record
Conditions
Mild to Moderate TBI, Posttraumatic Stress Disorder
Interventions
TTI-0102, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans

NCT02657317
View directory record Official record
Conditions
Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression, Opioid Use Disorder
Interventions
FORT-A, VA Treatment as Usual
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 72 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Testing a Self-Management App for Symptoms of Posttraumatic Stress

NCT04155736
View directory record Official record
Conditions
PTSD
Interventions
Renew
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Oct 4, 2026, 9:59 AM EDT
Not listed Phase 2 Interventional

A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD

NCT03339258
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Doxazosin Mesylate, Extended Release, Placebo
Drug
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Integrated Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)

NCT00127413
View directory record Official record
Conditions
Pain, Posttraumatic Stress Disorder
Interventions
Cognitive Behavioral Therapy - Pain, Cognitive Behavioral Therapy-Integrated, Cognitive Processing Therapy - PTSD, Treat as Usual
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 27, 2015 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Early Phase 1 Interventional

Written Exposure Therapy for Nurses

NCT06432374
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depressive Symptoms, Burn Out, Anxiety, Work Related Stress
Interventions
WET
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 29, 2024 · Synced Oct 4, 2026, 9:59 AM EDT
Not yet recruiting Not applicable Interventional

CHW-Enhanced Trauma Recovery

NCT07818161
View directory record Official record
Conditions
Traumatic Injury, Posttraumatic Stress Disorder, Depression, Social Determinants of Health
Interventions
CHW support
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Symptom-Targeted Approach to Rehabilitation for Concussion

NCT05091970
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Manualized cognitive rehabilitation for mild traumatic brain injury (mTBI)
Procedure
Lead sponsor
South Texas Veterans Health Care System
Federal
Eligibility
18 Years to 65 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD)

NCT00984698
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Insomnia Disorder
Interventions
Cognitive Behavioral Social Rhythm Group Therapy, Present Centered Group Therapy
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 31, 2014 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Phase 1Phase 2 Interventional

Psychological First Aid for Victims of Crime

NCT01934348
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Substance Use
Interventions
Psychological First Aid, Usual victim advocacy Services
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Oct 4, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Pediatric and Caregiver Traumatic Stress Intervention (PACTS)

NCT06366282
View directory record Official record
Conditions
Traumatic Injury
Interventions
Caregiver Counseling for Childhood Traumatic Injury, Standard of Care for Childhood Traumatic Injury
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
1 Year to 6 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 4, 2026, 9:59 AM EDT