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Showing 1–24 of 162 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Posttraumatic Stress Symptoms Clear all
Completed Not applicable Interventional

Pediatric and Caregiver Traumatic Stress Intervention (PACTS)

NCT06366282
View directory record Official record
Conditions
Traumatic Injury
Interventions
Caregiver Counseling for Childhood Traumatic Injury, Standard of Care for Childhood Traumatic Injury
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
1 Year to 6 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 16, 2026, 4:16 PM EDT
Not listed Phase 2 Interventional

A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD

NCT03339258
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Doxazosin Mesylate, Extended Release, Placebo
Drug
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional

Testing a Self-Management App for Symptoms of Posttraumatic Stress

NCT04155736
View directory record Official record
Conditions
PTSD
Interventions
Renew
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2021 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Early Phase 1 Interventional

Written Exposure Therapy for Nurses

NCT06432374
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depressive Symptoms, Burn Out, Anxiety, Work Related Stress
Interventions
WET
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional Results available

Integrated Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)

NCT00127413
View directory record Official record
Conditions
Pain, Posttraumatic Stress Disorder
Interventions
Cognitive Behavioral Therapy - Pain, Cognitive Behavioral Therapy-Integrated, Cognitive Processing Therapy - PTSD, Treat as Usual
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional

Treating Post Traumatic Stress Disorder in Children Exposed to Domestic Violence

NCT00183326
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Anxiety, Depression
Interventions
Trauma-focused cognitive behavioral therapy (TF-CBT), Child-centered supportive therapy (CCT)
Behavioral
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
7 Years to 14 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 16, 2026, 4:16 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Labor Education to Reduce Postpartum Traumatic Stress

NCT06992791
View directory record Official record
Conditions
Postpartum Complication, Posttraumatic Stress Symptoms
Interventions
Prenatal Education on Childbirth
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 51 Years · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Phase 2 Interventional Results available

Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD

NCT01793610
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Comparator Dose (40mg) MDMA HCl, Active Dose 2 (100 mg) MDMA HCl, Active Dose 1 (125 mg) MDMA HCl, Psychotherapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Sep 16, 2026, 4:16 PM EDT
Withdrawn Not applicable Interventional

Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment

NCT01007006
View directory record Official record
Conditions
Traumatic Brain Injury, Posttraumatic Stress Disorders, Trauma, Combat Disorders, Pain
Interventions
TMRDU
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
3
States / cities
Camp Pendleton, California • Tampa, Florida • Fort Knox, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Evaluation of the Pregnant Moms' Empowerment Program

NCT05011825
View directory record Official record
Conditions
Violence, Depression, Posttraumatic Stress Disorder, Parenting, Infant Development, Child Behavior
Interventions
Pregnant Moms' Empowerment Program
Behavioral
Lead sponsor
University of Notre Dame
Other
Eligibility
16 Years to 55 Years · Female only
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
2
States / cities
Notre Dame, Indiana • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial

NCT05534126
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Chronic Pain
Interventions
Stellate Ganglion Block Treatment, Placebo
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional Results available

Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)

NCT00990106
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Combat Disorders, Sleep Disorders
Interventions
prazosin hydrochloride, placebo
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 22, 2018 · Synced Sep 16, 2026, 4:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder

NCT00025974
View directory record Official record
Conditions
Panic Disorder, Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional

Loving-kindness Meditation for Posttraumatic Stress Disorder (PTSD)

NCT01607632
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
loving-kindness meditation
Behavioral
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 29, 2012 · Synced Sep 16, 2026, 4:16 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Grappling With Trauma: Brazilian Jiu-Jitsu for First Responders

NCT07783516
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD), Trauma and Stress Related Disorders, Occupational Stress, Emotional Regulation Difficulties, Anger Problems, Relational Problems, Irritability
Interventions
Brazilian Jiu-Jitsu Program
Behavioral
Lead sponsor
Sam Houston State University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Conroe, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 16, 2026, 4:16 PM EDT
Not listed Not applicable Interventional

Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder and Borderline Personality Disorder (PTSD-BPD)

NCT04230668
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Borderline Personality Disorder
Interventions
Cognitive Processing Therapy with Suicide Risk Management, Treatment as Usual with Suicide Rick Management
Behavioral
Lead sponsor
Palo Alto University
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 16, 2024 · Synced Sep 16, 2026, 4:16 PM EDT
Terminated Phase 4 Interventional Results available

PTSD Symptom Reduction by Propranolol Given After Trauma Memory Activation

NCT00645450
View directory record Official record
Conditions
Posttraumatic Stress Disorders
Interventions
Propranolol, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional

The Role of Exercise in the Treatment of PTSD Symptoms

NCT02649127
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
imaginal therapy, exercise, self-care
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2017 · Synced Sep 16, 2026, 4:16 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

NCT05624931
View directory record Official record
Conditions
Depression, Posttraumatic Stress Disorder, Pregnancy Related, Medication Adherence
Interventions
Brief CBT-Based Intervention, Enhanced Treatment as Usual
Behavioral · Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
15 Years and older · Female only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Phase 3 Interventional Results available

Re-Engineering Systems for the Primary Care Treatment for PTSD

NCT00373698
View directory record Official record
Conditions
Stress Disorders, Posttraumatic, Depression
Interventions
Three Component Model of Collaborative Care
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
4
States / cities
Dallas, Texas • Temple, Texas • Waco, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Sep 16, 2026, 4:16 PM EDT
Withdrawn Not applicable Interventional

Effects of CBD Oil on Memory Reconsolidation and Trauma-Related Symptoms

NCT05892276
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Trauma Memory Reactivation, Cannabidiol (CBD) Broad-Spectrum Oil, Placebo Oil
Behavioral · Dietary Supplement
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Sep 16, 2026, 4:16 PM EDT
Completed Not applicable Interventional Results available

Trauma Survivors Outcomes and Support Study IV

NCT01625416
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury, Alcohol Use, Drug Use
Interventions
Stepped Care Management
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
14 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Sep 16, 2026, 4:16 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Inflammatory Challenge and Fear

NCT06630884
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Typhoid VI Polysaccharide Vaccine Injectable Solution, Saline Placebo (0.5mL injection)
Biological · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 60 Years
Enrollment
288 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 16, 2026, 4:16 PM EDT
Completed No phase listed Observational

Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Chronic Posttraumatic Stress Disorder (PTSD)

NCT00001657
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 16, 2026, 4:16 PM EDT