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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: PrEP Adherence Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Project ADHERE: Clinical Proof-of-Concept of a Tenofovir (TFV) Aptamer-Based Biosensor

NCT04870671
View directory record Official record
Conditions
HIV/AIDS, Adherence, Medication, Drug Use
Interventions
Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC)
Drug
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

PrEP iT! Mobile App Intervention

NCT04509076
View directory record Official record
Conditions
Treatment Adherence and Compliance
Interventions
PrEP iT! (plus usual PrEP care), Usual PrEP care
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 6, 2023 · Synced Jul 22, 2026, 6:53 PM EDT
Not yet recruiting Not applicable Interventional

Trans STAIR: Implementing an Evidence Based Trauma Treatment With Community Led PrEP Navigation

NCT06724965
View directory record Official record
Conditions
PrEP Uptake Experiences, PrEP Adherence Experiences, Mental Health Symptoms
Interventions
Trans STAIR, PrEP Well
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimizing PrEP Uptake & Adherence Among Male Sex Workers (MSW) Using a 2-stage Randomization Design

NCT03086057
View directory record Official record
Conditions
Prevention
Interventions
PrEPare for Work: Strength Based Case Management (Stage 1), PrEPare for Work: Adherence Training and Counseling (Stage 2)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 14, 2021 · Synced Jul 22, 2026, 6:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Mobile Gaming App to Improve Adherence to PrEP

NCT05762705
View directory record Official record
Conditions
Medication Adherence, HIV/AIDS
Interventions
Multilevel Gaming Adherence Intervention, Treatment as Usual +
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
15 Years to 34 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
3
States / cities
Boston, Massachusetts • Jackson, Mississippi • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Controlled Trial of iTAB Plus Motivational Interviewing for PrEP Adherence in Transgender Individuals

NCT03086200
View directory record Official record
Conditions
Patient Adherence, HIV Seronegativity
Interventions
brief Motivational Interviewing
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
263 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
5
States / cities
Los Angeles, California • San Diego, California • Torrance, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2021 · Synced Jul 22, 2026, 6:53 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

MyPrEP Plus: Development and Pilot Testing of Novel Preexposure Prophylaxis Decision Support Tools for Transgender Women

NCT07146139
View directory record Official record
Conditions
HIV Pre-exposure Prophylaxis, HIV Prevention and Care, Mobile Health Technology (mHealth), Adherence, Doxycycline STI PEP
Interventions
MyPrEP Plus Package, Standard of Care (SOC)
Device · Behavioral
Lead sponsor
Public Health Foundation Enterprises, Inc.
Other
Eligibility
18 Years and older · Male only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jul 22, 2026, 6:53 PM EDT
Completed No phase listed Observational

Adherence, HIV-1 Infection, Resistance, and Renal and Skeletal Adverse Event in Individuals Taking Truvada® for HIV Pre-Exposure Prophylaxis (PrEP)

NCT01906255
View directory record Official record
Conditions
HIV
Interventions
Not listed
Lead sponsor
Gilead Sciences
Industry
Eligibility
18 Years and older
Enrollment
10,577 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Foster City, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2021 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Addressing Health Disparities in Engagement, Retention, and Utilization of PrEP Among South Florida Women of Color

NCT05338996
View directory record Official record
Conditions
HIV Prevention, PrEP Adherence
Interventions
iENGAGE for PrEP
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
3
States / cities
Miami, Florida • West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Jul 22, 2026, 6:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation

NCT07292584
View directory record Official record
Conditions
HIV Prevention, HIV Risk, Sexual and Reproductive Health
Interventions
Interactive Digital PrEP Toolkit
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Female only
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
4
States / cities
Birmingham, Alabama • Montgomery, Alabama • Tuscaloosa, Alabama + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adaptive Intervention to Facilitate PrEP Uptake/Adherence Among Transgender Women

NCT05016232
View directory record Official record
Conditions
Prevention
Interventions
PrEP N' Shine: Strength Based Case Management (Stage 1), PrEP N' Shine: Stepped Adherence Training and Counseling (Stage 2)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Phase 3 Interventional

SmartSteps: A Context-Aware, PrEP Adherence Intervention for Individuals With Substance Use Disorder

NCT05378399
View directory record Official record
Conditions
HIV Infections, Substance Use, Adherence, Medication, Adherence, Treatment
Interventions
Descovy or Truvada, ID-Cap System, Beiwe
Drug · Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older · Male only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep

NCT01695863
View directory record Official record
Conditions
Colorectal Cancer
Interventions
comparing 2 drugs on their effect on the bowel preparation for colonoscopy
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Jul 22, 2026, 6:53 PM EDT
Not yet recruiting No phase listed Observational

Long-Acting Injectable HIV PrEP PROs

NCT07379658
View directory record Official record
Conditions
HIV Pre-exposure Prophylaxis
Interventions
Interview and survey to evaluate patient reported outcomes between the two medications.
Other
Lead sponsor
Anupama Raghuram MD
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jul 22, 2026, 6:53 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Pre-exposure Prophylaxis (PrEP) Adherence for Black MSM

NCT06661343
View directory record Official record
Conditions
HIV Prevention
Interventions
C4 Program, C4 + 3MV Program
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Male only
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
2
States / cities
New York, New York • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jul 22, 2026, 6:53 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

IN-US-276-1340: Pre-Exposure Prophylaxis to Prevent HIV Acquisition in US Women: A Demonstration Project

NCT03058835
View directory record Official record
Conditions
PrEP Adherence Monitoring
Interventions
tenofovir disoproxil and emtricitabine
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2025
U.S. locations
4
States / cities
Atlanta, Georgia • Chicago, Illinois • Newark, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional

Using Smart Phone Technology to Support PrEP Uptake and Adherence

NCT04868383
View directory record Official record
Conditions
HIV Prevention, PrEP, Adherence, Medication
Interventions
Use of smart phone technology to support medication adherence and uptake
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 29, 2021 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Demonstration Project

NCT04077151
View directory record Official record
Conditions
HIV/AIDS, Gender, Behavior and Behavior Mechanisms
Interventions
PrEP Demonstration Project
Behavioral
Lead sponsor
Hektoen Institute for Medical Research
Other
Eligibility
15 Years to 24 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional

Pepped on Pre-exposure Prophylaxis (PrEP): A Counseling and Problem-Solving PrEP Adherence Intervention for Stimulant Using Men Who Have Sex With Men (MSM).

NCT03137342
View directory record Official record
Conditions
PrEP Uptake, Stimulant Abuse, Adherence, Medication
Interventions
Pepped on PrEP Package
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 10, 2018 · Synced Jul 22, 2026, 6:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP)

NCT01808352
View directory record Official record
Conditions
HIV
Interventions
Observational
Other
Lead sponsor
HIV Prevention Trials Network
Network
Eligibility
18 Years and older · Male only
Enrollment
226 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
3
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - PK Study

NCT03652623
View directory record Official record
Conditions
HIV/AIDS, Gender, Behavior and Behavior Mechanisms
Interventions
TDF/FTC
Drug
Lead sponsor
Hektoen Institute for Medical Research
Other
Eligibility
15 Years to 24 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 31, 2024 · Synced Jul 22, 2026, 6:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Intervention Development

NCT04077138
View directory record Official record
Conditions
HIV/AIDS, Gender, Behavior and Behavior Mechanisms
Interventions
Not listed
Lead sponsor
Hektoen Institute for Medical Research
Other
Eligibility
15 Years to 24 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
3
States / cities
Denver, Colorado • Chicago, Illinois • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2024 · Synced Jul 22, 2026, 6:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Increasing PrEP With Trans Women in the Deep South

NCT05689281
View directory record Official record
Conditions
Hiv
Interventions
Peer PrEP Navigation
Behavioral
Lead sponsor
CrescentCare
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Jul 22, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing PrEP in Community Settings (EPIC)

NCT02371525
View directory record Official record
Conditions
HIV
Interventions
Prepmate
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Jul 22, 2026, 6:53 PM EDT