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ClinicalTrials.gov public records Last synced Sep 17, 2026, 9:36 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: PreDiabetes Clear all
Active, not recruiting Not applicable Interventional Results available

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

NCT05318183
View directory record Official record
Conditions
PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
Interventions
Whole Wheat Bread, White Bread (control)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Active, not recruiting Not applicable Interventional

Diabetes Prevention in Hispanic Adults Using Constant Glucose Monitors

NCT06864728
View directory record Official record
Conditions
Prediabetes / Type 2 Diabetes
Interventions
Video Diabetes Education, In person or virtual diabetes education
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Using Peer Support to Aid in Prevention and Treatment in Prediabetes

NCT03689530
View directory record Official record
Conditions
PreDiabetes
Interventions
Peer Support, Enhanced Usual Care
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 99 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
Oakland, California • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 2, 2023 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 1 Interventional

Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)

NCT04373265
View directory record Official record
Conditions
Adrenocortical Carcinoma
Interventions
Relacorilant, Pembrolizumab
Drug
Lead sponsor
Corcept Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
6
States / cities
Stanford, California • Tampa, Florida • Ann Arbor, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Sep 17, 2026, 9:36 PM EDT
Recruiting Not applicable Interventional

Post Prandial Individual Responses to Different Foods

NCT06989164
View directory record Official record
Conditions
PreDiabetes, Diabetes Mellitus, Type 2, Healthy
Interventions
Post prandial testing
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 1Phase 2 Interventional

We Can Prevent Diabetes: A Behavioral Intervention to Reduce Diabetes Risk in African Americans

NCT01227473
View directory record Official record
Conditions
Prediabetes
Interventions
Mindfulness-based diabetes prevention education group, Conventional diabetes prevention education group
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 14, 2012 · Synced Sep 17, 2026, 9:36 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Metabolic Adaptations to High-fat Diet

NCT06537401
View directory record Official record
Conditions
Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
Interventions
Hypercaloric, High Fat Diet
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
20 Years to 45 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional

Role of Slowly Digesible Starch on Diabetes Risk Factors

NCT01708694
View directory record Official record
Conditions
Prediabetes
Interventions
Amylose, Amylopectin
Dietary Supplement
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
35 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 14, 2017 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults

NCT02364570
View directory record Official record
Conditions
Prediabetes, Cardiovascular Disease
Interventions
Glucose (100g), Glucose (75g), Whole Eggs, Egg Whites, Egg Yolks
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Sep 17, 2026, 9:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

PreDM Clinical Decision Support Intervention

NCT04335331
View directory record Official record
Conditions
PreDiabetes
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
7,424 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 17, 2026, 9:36 PM EDT
Recruiting No phase listed Observational

Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

NCT05799222
View directory record Official record
Conditions
Overweight, PreDiabetes, Diabetes Type 2, Obesity
Interventions
Bariatrix Meal Replacement Products
Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional

Integrating Lifestyle Therapy for Diabetes Prevention Into Primary Care

NCT00853801
View directory record Official record
Conditions
Pre-Diabetes, Metabolic Syndrome, Type 2 Diabetes
Interventions
Lifestyle intervention and provider feedback
Behavioral
Lead sponsor
Cook County Health
Government
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 25, 2023 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 4 Interventional Results available

Cardiovascular Effects of GLP-1 Receptor Activation

NCT03101930
View directory record Official record
Conditions
Obesity, PreDiabetes
Interventions
Liraglutide, Sitagliptin, hypocaloric diet, Placebos, Exendin (9-39)
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Diabetes in the Deep South: Extending Partnerships and Adapting Interventions to Reach Rural Communities at High Risk.

NCT04343872
View directory record Official record
Conditions
Pre-diabetes
Interventions
Receive lifestyle modification alone, Metformin therapy
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional

Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults

NCT06284681
View directory record Official record
Conditions
Obesity, Prehypertension, Hypertension, PreDiabetes, Type 2 Diabetes, Dyslipidemia
Interventions
Weight-focused health coaching, Weight-neutral health coaching, Intensify lifestyle approach, Augment with enhanced medical management
Behavioral · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Results available

Clinical Effectiveness of Body Fat Distribution Imaging in Real-World Practice: The BODY-REAL Study

NCT04763772
View directory record Official record
Conditions
Overweight and Obesity, PreDiabetes, Type 2 Diabetes, Cardiovascular Risk Factor
Interventions
Body Fat Distribution Imaging Report, Basic Weight Information, Patient Provided, Physician Provided
Diagnostic Test · Behavioral
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
35 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Results available

Evaluation of a Lifestyle Intervention for Employees With Prediabetes

NCT01682954
View directory record Official record
Conditions
Prediabetes, Overweight, Obese
Interventions
Lifestyle counseling
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 29, 2014 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Liraglutide on Hippocampal Structure and Function in Aging Adults With Prediabetes

NCT02140983
View directory record Official record
Conditions
Insulin Resistance, Dementia
Interventions
Liraglutide, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
50 Years to 70 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Sep 17, 2026, 9:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Night Owl Metabolism

NCT06507722
View directory record Official record
Conditions
PreDiabetes, Overweight, Impaired Glucose Tolerance
Interventions
Timing of OGTT, Timing of Standardized Meal
Diagnostic Test · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 23 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 17, 2026, 9:36 PM EDT
Active, not recruiting Not applicable Interventional

The Inspiring Action to Prevent Diabetes Intervention

NCT06001801
View directory record Official record
Conditions
PreDiabetes
Interventions
Diabetes Prevention Program, INSPIRA
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Recruiting No phase listed Observational

Rare and Atypical Diabetes Network

NCT05544266
View directory record Official record
Conditions
Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders, Metabolic Disease, Endocrine; Complications, Endocrine System Diseases
Interventions
Not listed
Lead sponsor
University of South Florida
Other
Eligibility
Not listed
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
13
States / cities
Aurora, Colorado • Chicago, Illinois • Indianapolis, Indiana + 10 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

RISE Pediatric Medication Study

NCT01779375
View directory record Official record
Conditions
Prediabetes, Type 2 Diabetes
Interventions
Metformin, Glargine
Drug
Lead sponsor
RISE Study Group
Network
Eligibility
10 Years to 19 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
4
States / cities
Denver, Colorado • New Haven, Connecticut • Indianapolis, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Sep 17, 2026, 9:36 PM EDT
Terminated No phase listed Observational

Impaired Glucose Tolerance and Cognition in MS

NCT04748302
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Not listed
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 59 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 9, 2021 · Synced Sep 17, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treating the Endothelium to Restore Insulin Sensitivity

NCT00402194
View directory record Official record
Conditions
Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
Interventions
Losartan
Drug
Lead sponsor
Indiana University
Other
Eligibility
20 Years to 55 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 23, 2013 · Synced Sep 17, 2026, 9:36 PM EDT