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ClinicalTrials.gov public records Last synced Oct 21, 2026, 10:56 PM EDT

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Showing 1–24 of 406 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: PreP Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Men's Prevention Apps to Research Efficacy

NCT03965221
View directory record Official record
Conditions
HIV/AIDS, Sexually Transmitted Diseases, Pre-exposure Prophylaxis, Risk Reduction
Interventions
LYNX, MyChoices
Behavioral
Lead sponsor
Public Health Foundation Enterprises, Inc.
Other
Eligibility
15 Years to 29 Years · Male only
Enrollment
381 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
8
States / cities
Tampa, Florida • Atlanta, Georgia • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project WERK (Wellness Encouragement Respect Kinship)

NCT03148171
View directory record Official record
Conditions
HIV Prevention
Interventions
WERK Supportive Contact
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
290 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 10, 2024 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Biomarkers for Event-driven PrEP Adherence

NCT04298697
View directory record Official record
Conditions
Human Immunodeficiency Virus
Interventions
Tenofovir disoproxil fumarate/emtricitabine (TDF/FTC)
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 59 Years · Male only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Pre-Exposure Prophylaxis (PrEP)- Gender Affirming Hormone Therapy (GAHT) Interactions in TGW

NCT04760691
View directory record Official record
Conditions
HIV, Prophylaxis, Transgender
Interventions
Truvada alone, Truvada plus Leuprolide 11.25mg intramuscular injection, Truvada plus Estradiol 1 mg, Truvada plus Estradiol 6 mg, Estradiol 6 mg alone
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Male only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

An Open Label Demonstration Project and Phase II Safety Study of Pre-Exposure Prophylaxis

NCT01772823
View directory record Official record
Conditions
HIV Infection
Interventions
3MV, PCC, Emtricitabine/tenofovir (FTC/TDF (Truvada®))
Behavioral · Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 22 Years · Male only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
12
States / cities
Los Angeles, California • Aurora, Colorado • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

eSTEP: An Integrated mHealth Intervention to Engage High-risk Individuals Along the Full PrEP Care Continuum

NCT06159582
View directory record Official record
Conditions
Pre-Exposure Prophylaxis (PrEP)
Interventions
eSTEP, Usual Care
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years and older · Male only
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Welcome to PrEP School Utilizing Peer Educators to Improve Uptake of Preexposure Prophylaxis for HIV at an HBCU

NCT07053527
View directory record Official record
Conditions
HIV Prevention Program
Interventions
PrEP Awareness and Uptake Educational Program
Behavioral
Lead sponsor
Morehouse School of Medicine
Other
Eligibility
18 Years to 26 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Food Pantry Client and Staff Preferences for Nutritious no Prep Ready-to-eat Meals

NCT05593510
View directory record Official record
Conditions
Diet, Healthy, Food Security
Interventions
No prep ready-to-eat meals, Ingredient bundles (e.g. meal kits)
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

TechStep: Technology-based Stepped Care to Stem Transgender Adolescent Risk Transmission

NCT04000724
View directory record Official record
Conditions
HIV
Interventions
Text Messaging (Text+Step), WebApp (App+Step), Information/No Step
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
15 Years to 24 Years
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
5
States / cities
Los Angeles, California • Boston, Massachusetts • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Results available

Integrated PrEP Interventions for People Who Inject Drugs in Rural Kentucky

NCT05037513
View directory record Official record
Conditions
HIV Prevention
Interventions
SBCM-PrEP, CDC-PrEP
Behavioral
Lead sponsor
Hilary L Surratt, PhD
Other
Eligibility
18 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mobile-health (mHealth) Intervention to Support HIV Self-testing and PrEP Uptake Among Young Men Who Have Sex With Men

NCT04865341
View directory record Official record
Conditions
Human Immunodeficiency Virus
Interventions
IMB, Information-Only Control
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
17 Years to 24 Years · Male only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Feasibility and Preliminary Impact of a mHealth App on Reducing STI Risk in Black MSM PrEP Users

NCT05395754
View directory record Official record
Conditions
STI, Sexually Transmitted Diseases, Pre-exposure Prophylaxis
Interventions
App Intervention
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Oct 21, 2026, 10:56 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

A Self-administered PrEP Decisional Aid for Dissemination With HIV Self-test Kits (DASH)

NCT07614165
View directory record Official record
Conditions
Pre-Exposure Prophylaxis (PrEP), HIV Prevention
Interventions
PrEP Decisional Aid for dissemination with Self-administered HIV test kits (DASH)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 39 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Completed No phase listed Observational

Optimizing CAB-LA as PrEP for Women Who Inject Drugs

NCT05799339
View directory record Official record
Conditions
HIV Infections, Opioid Use, Trauma, Psychological
Interventions
Not listed
Lead sponsor
Alexis Roth
Other
Eligibility
18 Years and older · Female only
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Navigating Insurance Coverage Expansion (NICE)

NCT04263441
View directory record Official record
Conditions
HIV/AIDS
Interventions
NICE Intervention
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older · Male only
Enrollment
630 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
3
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluating the Safety and Tolerability of Antiretroviral Drug Regimens Used as Pre-Exposure Prophylaxis to Prevent HIV Infection in At-Risk Men Who Have Sex With Men and in At-Risk Women

NCT01505114
View directory record Official record
Conditions
HIV Infection
Interventions
Maraviroc, Emtricitabine, Tenofovir disoproxil fumarate, Maraviroc placebo, Emtricitabine placebo, Tenofovir disoproxil fumarate placebo
Drug · Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
594 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
12
States / cities
Los Angeles, California • San Francisco, California • Washington D.C., District of Columbia + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2021 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional

A Simple Intervention to Increase Persistence on PrEP in MSM to Improve Decision Making

NCT06476847
View directory record Official record
Conditions
HIV Infections
Interventions
PrEP persistence
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older · Male only
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Centering Those Engaged in Transactional Sex: A PrEP Innovation for Getting To Zero

NCT05929521
View directory record Official record
Conditions
Sex Work, Pre-Exposure Prophylaxis
Interventions
C-PrEP+
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Leveraging Electronic Health Record Data in a Risk Prediction Model to Increase HIV PrEP Intake in Primary Care

NCT05991869
View directory record Official record
Conditions
Pre-Exposure Prophylaxis
Interventions
Point-of-care decision support intervention
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Study Evaluating Implementation Strategies for the Delivery of Cabotegravir in Low and High-Volume PrEP Site in the United States

NCT05374525
View directory record Official record
Conditions
HIV Infections
Interventions
APRETUDE, Cabotegravir OLI
Drug
Lead sponsor
ViiV Healthcare
Industry
Eligibility
18 Years and older · Male only
Enrollment
287 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
17
States / cities
Los Angeles, California • San Francisco, California • Washington D.C., District of Columbia + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

PrEP Affect Regulation Treatment Innovation

NCT04899024
View directory record Official record
Conditions
Medication Adherence, HIV Prevention, Stimulant Use
Interventions
PARTI, Attention-Control, Contingency Management for PrEP Adherence
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
18 Years and older · Male only
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
San Francisco, California • Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

NCT06477588
View directory record Official record
Conditions
HIV, Contingency Management, Justice Involved Populations, Status Neutral Interventions, Mental Health, Substance Use
Interventions
Health Navigation, Health Navigation, Employment Navigation plus Contingency Management Intervention
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

MAPS PrEP Van Study

NCT06908252
View directory record Official record
Conditions
HIV Infection
Interventions
Pre-Exposure Prophylaxis (PrEP)
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 21, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Proposed EZ2go Complete Bowel Cleansing System

NCT01838408
View directory record Official record
Conditions
Screening Colonoscopy, Surveillance Colonoscopy, Colonoscopy
Interventions
Ez2go Complete, LoSo Prep
Other
Lead sponsor
Borland-Groover Clinic
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 27, 2015 · Synced Oct 21, 2026, 10:56 PM EDT