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Showing 1–24 of 103 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Prebiotics Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Behavior of Infants Fed Formula Supplemented With Prebiotics

NCT02757924
View directory record Official record
Conditions
Gastrointestinal Tolerance
Interventions
Infant formula supplemented with prebiotics
Other
Lead sponsor
Abbott Nutrition
Industry
Eligibility
7 Days to 42 Days
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
11
States / cities
Dothan, Alabama • Pensacola, Florida • St. Petersburg, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Sep 1, 2026, 11:44 AM EDT
Not yet recruiting Not applicable Interventional

Comparing Prebiotic Fiber Supplements for Gut Health and Digestive Comfort

NCT07525180
View directory record Official record
Conditions
Healthy Participants
Interventions
LOAM, Inulin, Cellulose Placebo
Dietary Supplement
Lead sponsor
Ventoscity LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety, Tolerability, and Biosignature of Humanized Prebiotics in Healthy Adults

NCT06068894
View directory record Official record
Conditions
Intestinal Health
Interventions
"Humanized" galacto-oligosaccharides (hGOS), Galacto-oligosaccharides (GOS), Matching Placebo
Dietary Supplement · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Prebiotic in Preterm Infants

NCT03306316
View directory record Official record
Conditions
Preterm Infant, Development, Infant, Nutrition
Interventions
Prebiotic, Dextrose Control
Dietary Supplement
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
7 Days to 10 Days
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Prebiotic vs Probiotic in Multiple Sclerosis

NCT04038541
View directory record Official record
Conditions
Multiple Sclerosis, Clinically Isolated Syndrome (CIS)
Interventions
Prebiotics (Prebiotin Prebiotic Fiber Stick Pac), Probiotics (Visbiome®)
Dietary Supplement
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
New York, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of the Ability of a Supplement to Increase Good Bacteria in the Human Intestine and Blood Sugar Levels

NCT01944904
View directory record Official record
Conditions
Pre-diabetic
Interventions
Sugar Pill, XOS 2.8
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 70 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Effects of Xylooligosarcharide on Composition of the Human Colonic Microflora

NCT01861964
View directory record Official record
Conditions
Bifidobacteria, Healthy Volunteers
Interventions
Placebo (Maltodextrin), Xylooligosarcharide 1.4g, Xylooligosarcharide 2.8g
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2016 · Synced Sep 1, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional

Microbiome Modulation With Prebiotics in PTSD and Cirrhosis

NCT06464952
View directory record Official record
Conditions
Cirrhosis, PTSD
Interventions
Resistant potato starch, Powdered cellulose
Dietary Supplement
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Assessing the Short-Term Effects of Multi-Fiber Supplementation on Gut Health

NCT07787026
View directory record Official record
Conditions
Mixed Fiber Supplementation for Healthy Adults
Interventions
Prebiotic, Placebo
Dietary Supplement
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Probiotic and Prebiotic Combinations on Premature Infants

NCT00282113
View directory record Official record
Conditions
Premature Infants, Stool Bacterial Composition, Growth
Interventions
ProBioPlus, Culturelle, Placebo
Dietary Supplement · Other
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 7 Days
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jan 27, 2010 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

What's Hopping? Cricket Protein and Human Gut Microbiota

NCT03383341
View directory record Official record
Conditions
Healthy
Interventions
Cricket Protein Powder, Placebo control
Dietary Supplement · Other
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Sep 1, 2026, 11:44 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Multiomic Signatures of Microbial Metabolites Following Prebiotic Fiber Supplementation

NCT03925597
View directory record Official record
Conditions
Prebiotics
Interventions
Fiber cycles ARM 1, Fiber cycles ARM 2, Fiber cycles ARM 3, Fiber cycles ARM 4, Fiber cycles ARM 5, Fiber cycles ARM 6, Fiber cycles ARM 7, Fiber cycles ARM 8, Fiber cycles ARM 9, Fiber cycles ARM 10, Fiber cycles ARM 11, Fiber cycles ARM 12, Fiber cycles ARM 13, Fiber cycles ARM 14, Fiber cycles ARM 15, Fiber cycles ARM 16, Fiber cycles ARM 17, Fiber cycles ARM 18, Fiber cycles ARM 19, Fiber cycles ARM 20, Fiber cycles ARM 21, Fiber cycles ARM 22, Fiber cycles ARM 23, Fiber cycles ARM 24
Dietary Supplement
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Sep 1, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Synbiotic to Attenuate Resorption of the Skeleton

NCT06389539
View directory record Official record
Conditions
Osteoporosis, Inflammation, Aging
Interventions
SBD111 medical food, Placebo
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
60 Years and older · Female only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Prebiotic Fiber to Prevent Pathogen Colonization in the ICU

NCT03509753
View directory record Official record
Conditions
Sepsis
Interventions
High Fiber, Low Fiber
Dietary Supplement
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Effects of ISOThrive on Bodyweight, Body Composition, Hunger/Satiety and Cardiac Risk Measures in Overweight Adults

NCT02501356
View directory record Official record
Conditions
Obesity
Interventions
ISOThrive Supplement, Placebo Supplement
Dietary Supplement
Lead sponsor
Griffin Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Derby, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Sep 1, 2026, 11:44 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Effect of a Nutritional Supplement on Gut Microbiota in Adults

NCT06611215
View directory record Official record
Conditions
Changes in Gut Microbiota with Prebiotic Supplementation, Quality of Life
Interventions
Treatment, Placebo
Dietary Supplement
Lead sponsor
Pharmavite LLC
Industry
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study to Determine the Effect of a Cobiotic Formulation on the Gastrointestinal Microbiome

NCT01724736
View directory record Official record
Conditions
Pre Diabetic
Interventions
Placebo, NM504:
Drug
Lead sponsor
NuMe Health
Industry
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 23, 2014 · Synced Sep 1, 2026, 11:44 AM EDT
Active, not recruiting Not applicable Interventional

Ritual Synbiotic+, a Dietary Supplement Designed to Impact Gastrointestinal Health, Mood, and Behavior in Women

NCT06834984
View directory record Official record
Conditions
Gastrointestinal Disease Symptoms
Interventions
Prebiotic, probiotic, postbiotic combination, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
25 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Not yet recruiting Phase 2 Interventional

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

NCT07189585
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
inulin, Maltodextrin (Placebo)
Drug
Lead sponsor
Yale University
Other
Eligibility
40 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress

NCT05392556
View directory record Official record
Conditions
Stress Physiology
Interventions
Probiotic, Prebiotic, Placebo
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 25, 2025 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Prebiotics in Peritoneal Dialysis

NCT03265639
View directory record Official record
Conditions
End Stage Renal Disease, Gut Microbiome Dysbiosis
Interventions
P-inulin
Dietary Supplement
Lead sponsor
Ali Ramezani
Other
Eligibility
21 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2018 · Synced Sep 1, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Effects of Prebiotic Supplementation and Exercise on Inflammatory Markers, Vascular Function and Cognition in CKD

NCT03689569
View directory record Official record
Conditions
Chronic Kidney Diseases
Interventions
Resistant starch, Exercise, Starch
Dietary Supplement · Behavioral
Lead sponsor
Springfield College
Other
Eligibility
30 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional

Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular Therapy

NCT05135351
View directory record Official record
Conditions
Multiple Myeloma, Lymphoma
Interventions
Resistant Starch, Maltodextrin
Dietary Supplement
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 1, 2026, 11:44 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

GUT-FEELINGS: Using Citizen Science for Large-Scale Prebiotic Clinical Trials for Mental Health in Adults

NCT07752823
View directory record Official record
Conditions
Sleep Disturbance, Stress, Feeling Anxious
Interventions
Active Gut Feeling Product 1, Active Gut Feeling Product 2, Placebo Gut Feeling Control Product
Other
Lead sponsor
Holobiome, Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Del Mar, California
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 1, 2026, 11:44 AM EDT