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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pregnancy Termination in First Trimester Clear all
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss

NCT02141555
View directory record Official record
Conditions
Spontaneous Abortion in First Trimester
Interventions
Vaginal Misoprostol, Buccal Misoprostol
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 2 Interventional

Letrozole and Misoprostol for Early Pregnancy Loss Management

NCT06452719
View directory record Official record
Conditions
Early Pregnancy Loss, Miscarriage in First Trimester, Miscarriage
Interventions
Letrozole, Misoprostol
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Management With Medication Abortion Through 70 Days' Gestation

NCT03925129
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
high frequency TENS treatment, Sham TENS treatment
Device
Lead sponsor
Planned Parenthood of Greater New York
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional

Manual Versus Electric Vacuum Aspiration for Pregnancy Termination Between 10-14 Weeks

NCT03079622
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Electric Vacuum Aspiration, Manual Vacuum Aspiration
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Refining Paracervical Block Techniques for Pain Control in First Trimester Surgical Abortion

NCT01466491
View directory record Official record
Conditions
Pain
Interventions
Paracervical block technique with lidocaine
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
332 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 7, 2019 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 4 Interventional Results available

Pain Control In First Trimester Medical Abortion: A Randomized Trial

NCT01457521
View directory record Official record
Conditions
Pain
Interventions
Ibuprofen
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Chicago, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 4 Interventional Results available

Hydrocodone For Pain Control in First Trimester Surgical Abortion

NCT01330459
View directory record Official record
Conditions
Pain
Interventions
Hydrocodone/acetaminophen, Placebo, Ibuprofen, Lorazepam, Lidocaine
Drug
Lead sponsor
Elizabeth Micks
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

CCT-102 or Expectant Management in Delayed Pregnancy Loss

NCT06121063
View directory record Official record
Conditions
Early Pregnancy Loss, Delayed Pregnancy Loss
Interventions
CCT-102 A and CCT-102 B
Combination Product
Lead sponsor
Conceptra Biosciences, LLC
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
15
States / cities
Tucson, Arizona • San Fernando, California • Panama City, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 27, 2026, 8:08 PM EDT
Terminated Phase 4 Interventional Results available

Methadone and Medication Abortion

NCT04941443
View directory record Official record
Conditions
Pain, Medical Abortion
Interventions
Methadone Pill, Ibuprofen
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2023 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions

NCT00121329
View directory record Official record
Conditions
Pain
Interventions
Intrauterine lidocaine infusion 4%
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2004
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 20, 2005 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Study of Immediate Start of Progestin Contraceptives in Medical Abortion

NCT01902485
View directory record Official record
Conditions
Contraception
Interventions
Timing of Contraceptive Initiation in Medical Abortion
Other
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Female only
Enrollment
937 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
6
States / cities
Chula Vista, California • Eureka, California • Stamford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Paracervical Block for Pain Control in First Trimester Abortion

NCT01094366
View directory record Official record
Conditions
Legal Abortion With Complication, Pain
Interventions
Paracervical Block, Sham Paracervical Block
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 26, 2019 · Synced Sep 27, 2026, 8:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Preferences in Anesthesia for Abortion Care

NCT03030443
View directory record Official record
Conditions
Pregnancy Termination in First Trimester
Interventions
Not listed
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage.o

NCT03636451
View directory record Official record
Conditions
Abortion, Spontaneous, Abortion in First Trimester, Pain Uterus, Abortion Early, Abortion, Missed
Interventions
40cc buffered 0.5% lidocaine with 2 units of vasopressin paracervical block, 20cc 1% lidocaine with 2 units of vasopressin paracervical block
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Ketamine Versus Fentanyl for Surgical Abortions

NCT04871425
View directory record Official record
Conditions
Abortion in First Trimester, Pain, Procedural, Opioid Use
Interventions
Ketamine, Fentanyl
Drug
Lead sponsor
University of Washington
Other
Eligibility
14 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Renton, Washington
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During First Trimester Abortion

NCT03187002
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Transcutaneous electrical nerve stimulation (TENS), Moderate IV Sedation, SHAM: Transcutaneous electrical nerve stimulation (TENS), SHAM: Moderate IV Sedation
Device · Drug · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2020 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacist Provision of Medication Abortion

NCT04956731
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Pharmacist Provision of Medication Abortion
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Paracervical Block in First Trimester Surgical Abortions

NCT00617097
View directory record Official record
Conditions
Pain, Surgical Abortion
Interventions
lidocaine, ketorolac and lidocaine
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Auriculotherapy - Pain Management of Aspiration Abortion

NCT03896022
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Acupressure with Beads, Acupuncture with Needles, Placebo Adhesive Disks
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
177 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Sep 27, 2026, 8:08 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Research on Equity in Abortion Care by TeleHealth

NCT06787274
View directory record Official record
Conditions
Abortion in First Trimester, Abortion Early, Abortion; Attempted
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years to 64 Years
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Virtual Reality Experience in First Trimester D&C

NCT03533036
View directory record Official record
Conditions
First Trimester Abortion, Virtual Reality
Interventions
applied VR headset
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2019 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Nerve Stimulation for Pain Control During First-trimester Abortion

NCT05320432
View directory record Official record
Conditions
Abortion in First Trimester, Pain
Interventions
Transcutaneous electrical nerve stimulation (TENS), Sham
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Sep 27, 2026, 8:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide for Pain Management of First Trimester Surgical Abortion

NCT02096575
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Nitrous oxide administration
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Sep 27, 2026, 8:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Blood Loss at the Time of First Trimester Surgical Abortion in Anticoagulated Women

NCT00614432
View directory record Official record
Conditions
Blood Loss
Interventions
Not listed
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
2
States / cities
Honolulu, Hawaii • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 17, 2022 · Synced Sep 27, 2026, 8:08 PM EDT