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ClinicalTrials.gov public records Last synced May 22, 2026, 5:06 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Premature Rupture of Membranes Clear all
Withdrawn Phase 4 Interventional
View directory record Official record
Conditions
Chorioamnionitis, Intrapartum Fever, Intra-amniotic Infection
Interventions
Standard Antibiotic Treatment, No Antibiotic Treatment
Drug · Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced May 22, 2026, 5:06 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth, Preterm PROM (Pregnancy), Preterm Labor
Interventions
Antibiotics, oral Azithromycin and oral Amoxicillin
Drug
Lead sponsor
Woman's
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 10, 2021 · Synced May 22, 2026, 5:06 AM EDT
Completed Phase 1Phase 2 Interventional
View directory record Official record
Conditions
Labor, Premature, Preterm Premature Rupture of the Membranes, Infection, Inflammation, Chorioamnionitis
Interventions
amniocentesis, N-acetylcysteine or placebo
Procedure · Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2018
U.S. locations
2
States / cities
New Haven, Connecticut • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced May 22, 2026, 5:06 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Chorioamnionitis
Interventions
gentamicin
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2011 · Synced May 22, 2026, 5:06 AM EDT
Terminated Not applicable Interventional
View directory record Official record
Conditions
Preterm Premature Rupture of the Membranes, Physical Activity
Interventions
Moderate Activity
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2019 · Synced May 22, 2026, 5:06 AM EDT
Terminated No phase listed Observational
View directory record Official record
Conditions
Rupture of Fetal Membranes
Interventions
AmniSure ROM test
Device
Lead sponsor
QIAGEN Gaithersburg, Inc
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
4
States / cities
Fresno, California • Indianapolis, Indiana • Kansas City, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2016 · Synced May 22, 2026, 5:06 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 45 Years
Enrollment
746 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced May 22, 2026, 5:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Premature Rupture of Membrane, Unfavorable Cervix
Interventions
Intracervical balloon catheter, Oxytocin
Device · Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 25, 2024 · Synced May 22, 2026, 5:06 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy), PROM (Pregnancy), Premat Rupture Membranes Preterm Unspec to Length of Time Between Rupture/Labor, Premature Birth
Interventions
Azithromycin Pill, Amoxicillin Pill
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
3
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced May 22, 2026, 5:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
PPROM
Interventions
Speculum Exams, Digital Exams
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced May 22, 2026, 5:06 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Fever
Interventions
Not listed
Lead sponsor
MemorialCare
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
2
States / cities
Long Beach, California • Orange, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2008 · Synced May 22, 2026, 5:06 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Preterm Premature Rupture of Membranes
Interventions
indomethacin
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
15 Years to 50 Years · Female only
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced May 22, 2026, 5:06 AM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
PPROM, Respiratory Distress Syndrome in Premature Infants
Interventions
Betamethasone, Placebo
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced May 22, 2026, 5:06 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Preterm Birth, Preterm Labor, Bacteremia, Preterm Premature Rupture of Fetal Membranes
Interventions
Prenatal vitamin-mineral containing 3 mg fluoride, Prenatal vitamin-mineral containing 0 mg fluoride
Drug · Dietary Supplement
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced May 22, 2026, 5:06 AM EDT
Completed Phase 4 Interventional
View directory record Official record
Conditions
Preterm Premature Rupture of Membrane
Interventions
Azithromycin 500 mg, Azithromycin Oral Product
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
14 Years to 65 Years · Female only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced May 22, 2026, 5:06 AM EDT
Terminated Phase 4 Interventional
View directory record Official record
Conditions
Fetal Membranes, Premature Rupture
Interventions
Retention of Cerclage, Removal of Cerclage, Removal vs. Retention of Cervical Cerclage
Procedure
Lead sponsor
Obstetrix Medical Group
Industry
Eligibility
18 Years to 60 Years · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2014
U.S. locations
23
States / cities
Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced May 22, 2026, 5:06 AM EDT
Not listed No phase listed Observational
View directory record Official record
Conditions
Fetal Membranes, Premature Rupture
Interventions
non- intervention study
Other
Lead sponsor
Pro-Lab Diagnostics
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Birmingham, Alabama • Indianapolis, Indiana • Dallas, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced May 22, 2026, 5:06 AM EDT
Terminated Not applicable Interventional Results available
View directory record Official record
Conditions
Preterm Labor, Preterm Birth
Interventions
PAMG-1 immunoassay
Device
Lead sponsor
Mark Santillan
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 2, 2019 · Synced May 22, 2026, 5:06 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Antenatal Corticosteroids
Interventions
Antenatal corticosteroids
Other
Lead sponsor
St. Louis University
Other
Eligibility
13 Years to 55 Years · Female only
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced May 22, 2026, 5:06 AM EDT
Completed Phase 2Phase 3 Interventional Results available
View directory record Official record
Conditions
Chorioamnionitis
Interventions
Unasyn, Ampicillin/gentamicin
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 17, 2018 · Synced May 22, 2026, 5:06 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Premature Rupture of Fetal Membranes
Interventions
CRB, Pitocin
Device · Drug
Lead sponsor
Cook Group Incorporated
Industry
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
4
States / cities
Tucson, Arizona • Tampa, Florida • Louisville, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced May 22, 2026, 5:06 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Music Therapy, Preterm Premature Rupture of Membrane (PPROM)
Interventions
Music Therapy Intervention
Behavioral
Lead sponsor
Christina Chianis Reed
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced May 22, 2026, 5:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Chorioamnionitis
Interventions
saline, ampicillin gentamicin, ampicillin gentamicin clindamycin
Drug
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced May 22, 2026, 5:06 AM EDT
Withdrawn Phase 3 Interventional
View directory record Official record
Conditions
Preterm Premature Ruptured Membranes
Interventions
Azithromycin, Erythromycin
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced May 22, 2026, 5:06 AM EDT