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ClinicalTrials.gov public records Last synced Oct 29, 2026, 9:49 AM EDT

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Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Prenatal Depression Clear all
Recruiting Not applicable Interventional

In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression

NCT05766475
View directory record Official record
Conditions
Postpartum Depression
Interventions
ROSE Program: In Person, ROSE Program: Virtual
Behavioral
Lead sponsor
University of Denver
Other
Eligibility
18 Years and older · Female only
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal Loss

NCT01867749
View directory record Official record
Conditions
Major Depressive Disorder, Miscarriage, Stillbirth, Neonatal Death
Interventions
Group Interpersonal Psychotherapy (IPT-G), Coping with Depression (CWD)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

Online Prenatal Trial in Mindfulness Sleep Management

NCT04016428
View directory record Official record
Conditions
Pregnancy Related, Insomnia, Depression
Interventions
OPTIMISM, Sleep Education
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive-Behavioral Therapy (CBT) in Women Discontinuing Antidepressant for Pregnancy

NCT01453114
View directory record Official record
Conditions
Depression, Postpartum Depression, Antenatal Depression
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 29, 2026, 9:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The DC Mother-Infant Behavioral Wellness Program

NCT05345834
View directory record Official record
Conditions
Perinatal Depression, Perinatal Anxiety, Prenatal Stress
Interventions
Patient Navigation, Adapted Cognitive-Behavioral Therapy
Behavioral
Lead sponsor
Children's National Research Institute
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional Results available

Minimum Intervention to Maintain a Postpartum Depression Prevention Program in Clinics Serving Low-income Women

NCT03267563
View directory record Official record
Conditions
Depression, Postpartum
Interventions
EIAU, LICF, HICF
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mentors Offering Maternal Support (M-O-M-S™): A Prenatal Program for Decreasing Maternal Anxiety and Depression

NCT03393637
View directory record Official record
Conditions
Anxiety Fear, Prenatal Depression, Infant, Low Birth Weight, Preterm Birth, Maternal
Interventions
Mentors Offering Maternal Support (M-O-M-S)
Behavioral
Lead sponsor
University of the Incarnate Word
Other
Eligibility
18 Years and older · Female only
Enrollment
1,717 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
3
States / cities
San Diego, California • San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 29, 2026, 9:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Pregnancy-Specific Anxiety on Placental Inflammatory and Oxidative Stress Response and Birth Outcomes

NCT04993742
View directory record Official record
Conditions
Placental Dysfunction, Prenatal Stress
Interventions
MOMS Intervention
Behavioral
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 29, 2026, 9:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers

NCT05044546
View directory record Official record
Conditions
Depression, Tobacco Use Disorder
Interventions
Behavioral Activation Therapy, Discussion, Health Education, Questionnaire Administration, Tobacco Cessation Counseling
Behavioral · Procedure · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 29, 2026, 9:49 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Can Oxytocin Level Predict Postpartum Depression?

NCT02020148
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

Integrated Chronotherapy for Perinatal Depression

NCT02053649
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Postpartum Depression
Interventions
Triple Chronotherapy, Usual Care
Behavioral · Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Oct 29, 2026, 9:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Fresh RX: NHS 2020

NCT04845230
View directory record Official record
Conditions
Premature Birth, Birth Weight, Post Partum Depression, Health Care Utilization, Nutrition Deficiency Due to Insufficient Food, Housing Problems, Fetal Complications, Food Deprivation
Interventions
FreshRx Nourishing Healthy Starts
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
14 Years to 55 Years · Female only
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 29, 2022 · Synced Oct 29, 2026, 9:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention

NCT05700760
View directory record Official record
Conditions
Postpartum Depression
Interventions
ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns), Enhanced Care as Usual (CAU)
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older · Female only
Enrollment
2,320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

Dialectical Behavior Therapy for Pregnant Women

NCT03938350
View directory record Official record
Conditions
Perinatal Depression
Interventions
Dialectical Behavior Therapy (DBT) Skills Training
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 30, 2022 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Perinatal Depression

NCT06525922
View directory record Official record
Conditions
Perinatal Depression
Interventions
Center M
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Oct 29, 2026, 9:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of a Prenatal Yoga Mobile App in African American Pregnant Women

NCT06353113
View directory record Official record
Conditions
Pregnancy Related, Mental Health Issue, Discrimination, Racial, Stress, Depression
Interventions
Down Dog Prenatal Yoga App
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 46 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

Wellness for 2: Understanding How to Foster Well Being for Mom and Her Baby

NCT02738216
View directory record Official record
Conditions
Pregnancy
Interventions
Prenatal Yoga, Mother Baby Wellness
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional Results available

Personalized Integrated Chronotherapy for Perinatal Depression

NCT04364646
View directory record Official record
Conditions
Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation, Pregnancy Related, Sleep Disturbance
Interventions
Personalized Integrated Chronotherapy
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Glen Oaks, New York • Chapel Hill, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

Medicaid Enhanced Prenatal/Postnatal Services Using a Nurse-Community Health Worker Team

NCT00536159
View directory record Official record
Conditions
Perinatal Depression, Stress, Prenatal Health Risk Behaviors, Child Development
Interventions
Medicaid Maternal and Infant Support Services, Nurse-CHW team
Other
Lead sponsor
Michigan State University
Other
Eligibility
16 Years and older · Female only
Enrollment
613 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2007 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Group Interpersonal Psychotherapy in Treating Women With Prenatal Depression

NCT00633178
View directory record Official record
Conditions
Depression
Interventions
Group interpersonal therapy (IPT), Treatment as usual (TAU)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

3D Maternal Fetal Bonding

NCT04540458
View directory record Official record
Conditions
Maternal-Fetal Relations, Paternal Behavior, Maternal Behavior
Interventions
3D printed model, Placebo
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 16, 2022 · Synced Oct 29, 2026, 9:49 AM EDT
Completed Not applicable Interventional

Intervention for IPV-exposed Pregnant Women

NCT04068662
View directory record Official record
Conditions
Postpartum Depression, Posttraumatic Stress Disorder, Infant Behavior, Violence, Parenting
Interventions
Pregnant Moms' Empowerment Program, Nondirective Support Group
Behavioral
Lead sponsor
University of Notre Dame
Other
Eligibility
3 Months to 55 Years · Female only
Enrollment
424 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Notre Dame, Indiana • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 29, 2026, 9:49 AM EDT
Withdrawn Not applicable Interventional

Preventing Postpartum Depression in Prenatal Care

NCT02741206
View directory record Official record
Conditions
Post-partum Depression
Interventions
Bellevue ROSE Intervention, Psycho-education session and usual, Standard of care Control, One Psycho-education session and usual, standard of care Control
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 22, 2017 · Synced Oct 29, 2026, 9:49 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy

NCT03809572
View directory record Official record
Conditions
Maternal Psychological Distress, Postpartum Depression, Prenatal Stress
Interventions
Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Oct 29, 2026, 9:49 AM EDT