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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Preoperative Anxiety Clear all
Recruiting Not applicable Interventional

Preoperative Opioid Tapering Before Spine Surgery

NCT07221786
View directory record Official record
Conditions
Opioid Consumption, Postoperative, Pain After Surgery, Opioid Dependency
Interventions
Opioid tapering with CBT and education, Opioid tapering with education alone
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadephia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Phase 3 Interventional Results available

A Comparison of Midazolam and Zolpidem as Oral Premedication in Children

NCT02096900
View directory record Official record
Conditions
Parental/Caregiver Anxiety, Child's Anxiety
Interventions
zolpidem, Midazolam
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
2 Years to 9 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Preoperative 3D Models and Shared Decision-making

NCT06625008
View directory record Official record
Conditions
Colorectal Cancer, Shared Decision Making, Anxiety, Informed Consent
Interventions
3D-printed model
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Phase 2 Interventional

A GameBoy as a Distraction Before Surgery in Children

NCT00176670
View directory record Official record
Conditions
Anxiety
Interventions
midazolam or GameBoy or parental presence
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
4 Years to 16 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 5, 2016 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Virtual Reality (VR) to Non-VR for Decreasing Preoperative/Procedural Anxiety

NCT05094141
View directory record Official record
Conditions
Preoperative Anxiety
Interventions
Virtual reality
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
5 Years to 12 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Phase 3 Interventional Results available

Music vs Midazolam During Preop Nerve Block Placement

NCT03069677
View directory record Official record
Conditions
Anxiety, Peripheral Nerve Block
Interventions
music, Midazolam
Other · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Jun 10, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of an Educational Nail Biopsy Video on Pre-operative Anxiety, Health Literacy, and Patient Satisfaction

NCT06274775
View directory record Official record
Conditions
Anxiety, Literacy, Satisfaction, Patient
Interventions
Educational Video
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Effects of Centering Pre-operative Counseling on Patient Reported Anxiety

NCT04068675
View directory record Official record
Conditions
Gynecologic Cancer, Ovarian Cancer, Endometrial Cancer, Uterine Cancer, Cervical Cancer
Interventions
Group pre-operative counseling
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional Results available

Guided Meditation to Decrease Perioperative Anxiety and Increase Patient Intraoperative Compliance in Vascular Surgery

NCT05837481
View directory record Official record
Conditions
Peripheral Vascular Disease
Interventions
Meditation
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
4
States / cities
Boston, Massachusetts • Newton, Massachusetts • Salem, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Impact of a Breath-controlled Video Game App

NCT04000646
View directory record Official record
Conditions
Anxiety Acute
Interventions
standard care, breath-controlled app
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
3 Years to 8 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Jun 10, 2026, 6:45 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Virtual Reality to Reduce Pre-Operative Anxiety

NCT04268914
View directory record Official record
Conditions
Virtual Reality, Augmented Reality, IV Stick, Mask Induction, Ambulatory Surgery, Pain, Anxiety
Interventions
Oculus Go VR, Mira Prism VR
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
10 Years to 21 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Impact of Pre-Sedation Virtual Reality Game on Post-Discharge Negative Behaviors in the Pediatric Emergency Department

NCT03980067
View directory record Official record
Conditions
Behavior, Child, Anxiety
Interventions
Virtual Reality Game
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
6 Years to 17 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preparing Children for Anesthesia With an Educational Pop-Up Book

NCT04796077
View directory record Official record
Conditions
Pediatric Preoperative Anxiety, Pediatric Coping
Interventions
Pop-Up Book
Other
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
5 Years to 12 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Duluth, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Preoperative Massage in Breast Surgery Patients

NCT01667328
View directory record Official record
Conditions
Anxiety, Presurgical Anxiety, Breast Cancer
Interventions
Massage therapy, Standard of care
Procedure
Lead sponsor
Vassar Brothers Medical Center
Other
Eligibility
18 Years and older
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Poughkeepsie, New York
Source: ClinicalTrials.gov public record
Updated May 2, 2018 · Synced Jun 10, 2026, 6:45 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Music vs Midazolam During Preop Nerve Block Placement - Part 2 Study On Anxiolytic Options Before Peripheral Nerve Blocks

NCT05610969
View directory record Official record
Conditions
Peripheral Nerve Block, Anxiety, Preoperative Anxiety
Interventions
Music, Midazolam
Other · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional Results available

Preoperative Acupuncture for Total Knee or Hip Arthroplasty

NCT06099223
View directory record Official record
Conditions
Knee Arthropathy, Hip Arthropathy, Anxiety
Interventions
Acupuncture needles
Device
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Animated Video Consultation for Reducing Pre-Operative Anxiety in Outpatient Dermatologic Surgery

NCT03344497
View directory record Official record
Conditions
Dermatology/Skin - Other
Interventions
VC Group
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Jun 10, 2026, 6:45 PM EDT
Enrolling by invitation Not applicable Interventional

Impact of Immersive Video Education on Cardiothoracic Surgery Anxiety and Outcomes

NCT07222839
View directory record Official record
Conditions
Anxiety
Interventions
Visually Immersive Video, Standard of Care
Behavioral
Lead sponsor
Baptist Health South Florida
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Jun 10, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional

Pre-Operative Guided Meditation to Reduce Pre-Operative Anxiety in Patients Undergoing Cancer-Directed Surgery

NCT06949943
View directory record Official record
Conditions
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Interventions
Behavioral Intervention, Electronic Health Record Review, Survey Administration
Behavioral · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional Results available

A Single Blinded Randomized Controlled Trial Testing the Efficacy of a Pediatric Interactive Relational Agent vs. Standard Preoperative Education

NCT04586569
View directory record Official record
Conditions
Anesthesia, Anesthesia Emergence Delirium, Procedural Anxiety
Interventions
Pediatric Interactive Relational Agent (PIRA)
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
4 Years to 10 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Implementing a Paced Deep Breathing Module to Decrease Preoperative Anxiety in Gynecological Surgery Patients

NCT03078790
View directory record Official record
Conditions
Anxiety
Interventions
iPad
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Jun 10, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Usual Care and Distraction (Tablet) in Children 3-5 Years Old

NCT05368961
View directory record Official record
Conditions
Anxiety
Interventions
Distraction, Usual care
Behavioral · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
3 Years to 5 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 31, 2024 · Synced Jun 10, 2026, 6:45 PM EDT