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Showing 1–24 of 137 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Presbyopia Condition Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Continuation Study To Monitor The Long Term Safety Of Patients Completing Protocols ACU-P08-020/020A

NCT01895088
View directory record Official record
Conditions
Presbyopia
Interventions
AcuFocus Corneal Inlay ACI 7000 PDT
Device
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
45 Years to 60 Years
Enrollment
271 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
13
States / cities
Fayetteville, Arkansas • Los Angeles, California • Newport Beach, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Apioc Contact Lens Feasibility

NCT03688672
View directory record Official record
Conditions
Ametropia, Myopia, Hyperopia, Astigmatism, Presbyopia
Interventions
Apioc Contact Lens Design
Device
Lead sponsor
Lentechs, LLC
Industry
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Clareon PanOptix Pro vs. Clareon PanOptix - Study A

NCT06400745
View directory record Official record
Conditions
Aphakia, Presbyopia
Interventions
CPO Pro IOL, CPO IOL, Cataract surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
8
States / cities
Torrance, California • Bloomfield Hills, Michigan • Kansas City, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Assessment of a Customized Free-form Progressive Addition Lens Spectacle

NCT01234207
View directory record Official record
Conditions
Presbyopia
Interventions
Standard, non-free-form, non-customized PAL spectacles, Individually customized free-form surfaced PAL spectacles
Device
Lead sponsor
University of California, Berkeley
Other
Eligibility
39 Years to 80 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Vivity IOL: Emmetropia Compared to Monovision.

NCT05464732
View directory record Official record
Conditions
Presbyopia
Interventions
Vivity IOL emmetropia, Vivity IOL monovision
Device
Lead sponsor
Carolina Eyecare Physicians, LLC
Other
Eligibility
50 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Sep 4, 2026, 10:53 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Phase 1/2 Study of AGN-241622 in Healthy Participants and Participants With Presbyopia

NCT04403763
View directory record Official record
Conditions
Presbyopia
Interventions
AGN-241622, Vehicle
Drug
Lead sponsor
AbbVie
Industry
Eligibility
40 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
10
States / cities
Inglewood, California • Los Angeles, California • Mission Hills, California + 7 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2024 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Efficacy Study of BRIMOCHOL™, BRIMOCHOL™ F, and Carbachol in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia

NCT04774237
View directory record Official record
Conditions
Presbyopia
Interventions
BRIMOCHOL™, BRIMOCHOL™ F, Carbachol
Drug
Lead sponsor
Visus Therapeutics
Other
Eligibility
45 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
3
States / cities
Glendale, California • Newport Beach, California • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized, Active-Controlled, Double-Masked, Crossover Study to Evaluate the Clinical Performance of Deseyne (Vifilcon C) Daily Disposable Soft Contact Lens for Presbyopia Extended Depth of Focus (EDOF)

NCT06698731
View directory record Official record
Conditions
Presbyopia Condition
Interventions
Test lens, Control lens
Device
Lead sponsor
Bruno Vision Care
Industry
Eligibility
45 Years to 70 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
3
States / cities
Longwood, Florida • Pittsburg, Kansas • Warwick, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 4, 2026, 10:53 AM EDT
Terminated Phase 2 Interventional Results available

A Dose-ranging Study to Evaluate the Safety and Efficacy of UNR844 in Subjects With Presbyopia.

NCT04806503
View directory record Official record
Conditions
Presbyopia
Interventions
UNR844, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
45 Years to 55 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
12
States / cities
Laguna Hills, California • Newport Beach, California • Largo, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2024 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia

NCT05135286
View directory record Official record
Conditions
Presbyopia
Interventions
BRIMOCHOL™ PF, Carbachol PF, Vehicle
Drug
Lead sponsor
Visus Therapeutics
Other
Eligibility
45 Years to 80 Years
Enrollment
629 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
42
States / cities
Chandler, Arizona • Phoenix, Arizona • Sun City, Arizona + 39 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Performance Comparison of Two Monthly Replacement Silicone Hydrogel Multifocal Lens Types

NCT06232590
View directory record Official record
Conditions
Presbyopia
Interventions
Control Lens (comfilcon A), Test Lens (lehfilcon A)
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
42 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
4
States / cities
Medina, Minnesota • Vestal, New York • Granville, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Handling Comparison Between Two Contact Lens Types

NCT02310126
View directory record Official record
Conditions
Presbyopia
Interventions
etafilcon A (multi-focal), etafilcon A (sphere)
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
195 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
8
States / cities
Jacksonville, Florida • Sarasota, Florida • Winter Park, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

NCT05338333
View directory record Official record
Conditions
Presbyopia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, CLEAR CARE®
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
8
States / cities
Maitland, Florida • Orlando, Florida • Pittsburg, Kansas + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Evaluating Two Multifocal Daily Disposable Contact Lenses

NCT05579886
View directory record Official record
Conditions
Presbyopia
Interventions
Control Lens, Test Lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
42 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
5
States / cities
Ocoee, Florida • Pittsburg, Kansas • Vestal, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Investigation of the Vision-R800 Device.

NCT04208750
View directory record Official record
Conditions
Myopia, Hyperopia, Astigmatism, Presbyopia
Interventions
Vision R-800 Phoropter, Standard Phoropter
Device
Lead sponsor
Pete Kollbaum, OD, PhD
Other
Eligibility
18 Years to 70 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trial of the PresVIEW Implant for the Improvement of Near Vision in Patients With Presbyopia

NCT01166568
View directory record Official record
Conditions
Presbyopia
Interventions
PresVIEW Scleral Implants
Device
Lead sponsor
Refocus Group, Inc.
Industry
Eligibility
50 Years to 60 Years
Enrollment
337 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2015
U.S. locations
14
States / cities
Beverly Hills, California • San Diego, California • Des Plaines, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Sep 4, 2026, 10:53 AM EDT
Terminated No phase listed Observational

DAILIES TOTAL1® Soft Contact Lenses - Post-Market Clinical Follow-up Study

NCT06483113
View directory record Official record
Conditions
Myopia, Hyperopia, Presbyopia, Astigmatism
Interventions
Delefilcon A spherical soft contact lenses, Delefilcon A toric soft contact lenses, Delefilcon A multifocal soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
7 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
San Diego, California • Ponte Vedra Beach, Florida • West Palm Beach, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 4, 2026, 10:53 AM EDT
Completed No phase listed Observational Results available

Synergy Lens Outcomes Evaluation

NCT05418153
View directory record Official record
Conditions
Presbyopia, Pseudophakia
Interventions
Tecnis Synergy IOL
Device
Lead sponsor
Center For Sight
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
Venice, Florida • Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 17, 2024 · Synced Sep 4, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Applications of Advanced Ophthalmic Imaging

NCT03135327
View directory record Official record
Conditions
Multiple Sclerosis, Dry Eye Syndromes, Diabetic Retinopathy, Presbyopia, Myopia, Dementia
Interventions
Ocufolin
Dietary Supplement
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 99 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2029
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Dispensing Study of Two Marketed Daily Disposable Multifocal Contact Lenses

NCT07076160
View directory record Official record
Conditions
Visual Acuity, Presbyopia
Interventions
INFUSE® One Day Multifocal, ACUVUE® OASYS MAX 1-Day Multifocal Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
7
States / cities
Jacksonville, Florida • Longwood, Florida • Maitland, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Early Phase 1 Interventional

Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia

NCT06783686
View directory record Official record
Conditions
Pupil Constriction
Interventions
NV701, Pilocarpine 1.25% Eye drop
Drug
Lead sponsor
Novus Vision LLC
Industry
Eligibility
40 Years to 55 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Chandler, Arizona • Glendale, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Phase 2 Interventional

Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia

NCT02554396
View directory record Official record
Conditions
Presbyopia
Interventions
PRX-100, Placebo
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
45 Years to 59 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2017 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Phase 2 Interventional Results available

A Study of Safety and Efficacy of UNR844 Chloride (UNR844-Cl) Eye Drops in Subjects With Presbyopia.

NCT03809611
View directory record Official record
Conditions
Presbyopia
Interventions
UNR844-Cl, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
45 Years to 65 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
14
States / cities
Mission Hills, California • Newport Beach, California • Largo, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Sep 4, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Success of Habitual Multifocal Wearers When Refit With a New Lens Design

NCT04952701
View directory record Official record
Conditions
Presbyopia
Interventions
Control lenses, Test lenses
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
42 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
5
States / cities
Ocoee, Florida • Pittsburg, Kansas • Vestal, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Sep 4, 2026, 10:53 AM EDT