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Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pressure Pain Threshold Clear all
Completed No phase listed Observational Accepts healthy volunteers

The Effect of State and Trait Anxiety on Pain-pressure Threshold

NCT06047704
View directory record Official record
Conditions
Pain, Anxiety, Musculoskeletal Pain, Sensitisation
Interventions
No intervention
Other
Lead sponsor
Philadelphia College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Local and Widespread Hypoalgesic Effects of Neurodynamic Mobilization in Healthy Controls

NCT03674489
View directory record Official record
Conditions
Pain, Pain, Neuropathic
Interventions
Neurodynamic Slider Mobilization, Neurodynamic Tensioner Mobilization, Sham Neurodynamic Mobilization
Other
Lead sponsor
Brenau University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2019 · Synced Sep 3, 2026, 5:35 AM EDT
Suspended No phase listed Observational Accepts healthy volunteers

The Effect of Anxiety on Pain-pressure Threshold in a Healthy Population

NCT06586086
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Philadelphia College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Sep 3, 2026, 5:35 AM EDT
Not yet recruiting Not applicable Interventional

Marine Lipids Ease Painful TMD

NCT07437313
View directory record Official record
Conditions
Temporomandibular Disorder (TMD)
Interventions
SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 3, 2026, 5:35 AM EDT
Completed No phase listed Observational

Clinical Correlates of Pressure Pain Thresholds in Back and Leg Pain

NCT06653920
View directory record Official record
Conditions
Segmental Dysfunction of the Lumbar Spine, Back Pain, Leg Pain
Interventions
Chiropractic, Exercise, Cryotherapy, Spinalator
Other · Device
Lead sponsor
Leach Chiropractic Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Starkville, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Passive VR Versus Active VR on Heat Pain Thresholds and Pressure Pain Thresholds

NCT05836649
View directory record Official record
Conditions
Pain, Anxiety
Interventions
Oculus Go headset without active intervention, Oculus Go headset with active intervention, Oculus Go headset without immersive virtual reality experience, Oculus Go headset with immersive virtual reality experience
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 99 Years
Enrollment
265 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 3, 2026, 5:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Collagen Protein Versus Placebo on Muscle Recovery

NCT06465407
View directory record Official record
Conditions
Anthropometrics: Height and Weight, Isometric Standing and Seated Plantarflexion, Calf Muscle Thickness, Achilles Tendon Length and Thickness, Myotonography of the Calf Musculature and Achilles Tendon, Pain Pressure Threshold of the Calf, Pain Scale, Endurance Calf Test, Dietary Analysis
Interventions
Collagen, Maltodextrin
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional

Association Between Conditioned Pain Modulation and the 4-week Response to Spinal Mobilization in Adults With Chronic Neck Pain

NCT07194603
View directory record Official record
Conditions
Neck Pain Musculoskeletal, Chronic
Interventions
Spinal mobilization (SM) of the neck
Procedure
Lead sponsor
Azusa Pacific University
Other
Eligibility
18 Years to 55 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Azusa, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dry Needling and Shoulder Muscle Blood Flow, Motions, and Pain Sensitivity

NCT05467098
View directory record Official record
Conditions
Dry Needling, Shoulder Pain
Interventions
Dry Needling
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Duration of Effects of Massage in Healthy Participants

NCT05317702
View directory record Official record
Conditions
Healthy, Pressure Pain Threshold, Massage
Interventions
Moderately Painful Massage
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Sep 3, 2026, 5:35 AM EDT
Not listed Not applicable Interventional

The Effects of Thoracic Spine Manipulation in Individuals With Non-traumatic Cervical Pain

NCT01760590
View directory record Official record
Conditions
Neck Pain, Cervical Pain
Interventions
Manual Manipulation, Mobilization
Procedure
Lead sponsor
Keystone Rehabilitation Systems
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Bridgeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 3, 2013 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cranial Laser Reflex Technique for Hamstring Function

NCT03044106
View directory record Official record
Conditions
Hamstring Injury, Muscle Tone Increased, Muscle Pain, Muscle Weakness
Interventions
CLRT
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Immediate Effects Cervicothoracic Manipulation Versus Passive Upper Trapezius Stretch

NCT02552290
View directory record Official record
Conditions
Neck Pain
Interventions
Upper Trapezius Stretch, Cervicothoracic manipulation, No intervention
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Sep 16, 2015 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Looking Beyond the Immediate Effects of Lumbar Spinal Manipulation Using Pain Pressure Threshold in Asymptomatic Individuals

NCT06156605
View directory record Official record
Conditions
Lumbar Spine Injury, Pain
Interventions
Sidelying lumbar manipulation
Procedure
Lead sponsor
University of Mary
Other
Eligibility
18 Years to 50 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Bismarck, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Kettlebell Swings & Low Back Pressure Pain Threshold

NCT03696615
View directory record Official record
Conditions
Low Back Pain
Interventions
Tabata Kettlebell Swing Workout, Control
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 3, 2018 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lumbosacral Muscle Sensitivity & Pressure Pain Threshold After Kettlebell Swings

NCT05607212
View directory record Official record
Conditions
Muscle Soreness, Muscle Weakness, Muscle Tenderness
Interventions
Kettlebell Swing, Isometric Hold, Control
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 35 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Immediate Effects of Manipulation Versus Stretching on Upper Trapezius Pressure Pain Thresholds

NCT02081430
View directory record Official record
Conditions
Neurophysiological Mechanisms Manipulation
Interventions
CT Manipulation, Upper trapezius stretch
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 4, 2014 · Synced Sep 3, 2026, 5:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Pain and the Memory of Pain on Autonomic and Neuromuscular Function

NCT02269384
View directory record Official record
Conditions
Pain
Interventions
Experimental Noxious Stimulus, Memory of Experimental Noxious Stimulus, Memory of Prior Significant Injury, Mental Challenge Test
Procedure · Behavioral
Lead sponsor
Mount St. Mary's College, Los Angeles, CA
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 17, 2015 · Synced Sep 3, 2026, 5:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Two Different Dry-Needling Techniques for Low Back Pain

NCT03970486
View directory record Official record
Conditions
Low Back Pain
Interventions
Dry needling
Procedure
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Sep 3, 2026, 5:35 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time

NCT00042276
View directory record Official record
Conditions
Neck Pain
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
21 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Combined Effect of TENS and TaVNS on Pressure and Heat Pain Thresholds in Pain-Free Subjects

NCT06361381
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Active Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), Placebo Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), Transcutaneous Electrical Nerve Stimulation
Device
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 3, 2026, 5:35 AM EDT
Active, not recruiting Not applicable Interventional

Dry Needling and Shoulder Muscle Blood Flow, Motions, and Pain Sensitivity in Individuals with Shoulder Pain

NCT05596240
View directory record Official record
Conditions
Dry Needling, Shoulder Pain
Interventions
Dry Needling, Sham Dry Needling
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Sep 3, 2026, 5:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Self-myofascial Release With a Foam Roll Change Pressure Pain Thresholds in Lower Extremity Muscles

NCT02924259
View directory record Official record
Conditions
Myofascial Pain Syndromes
Interventions
The GRID foam roll
Device
Lead sponsor
California State University, Dominguez Hills
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Carson, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2016 · Synced Sep 3, 2026, 5:35 AM EDT