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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:58 AM EST

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Showing 1–24 of 61 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Preterm Premature Rupture of Membranes Clear all

Conditions: Chorioamnionitis
Interventions: Type of glove used for intrapartum vaginal exams; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older · Female only
Enrollment: 507 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Fetal Membranes, Premature Rupture, Labor, Induced/IS
Interventions: Transcervical Foley catheter; Device
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 12 Years to 55 Years · Female only
Enrollment: 169 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 3
States / cities: Birmingham, Alabama • Newark, Delaware • Greenville, South Carolina

Conditions: Music Therapy, Preterm Premature Rupture of Membrane (PPROM)
Interventions: Music Therapy Intervention; Behavioral
Lead sponsor: Christina Chianis Reed; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
Interventions: Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg, Ampicillin 2 GM Injection, Amoxicillin 250 MG, Azithromycin, Erythromycin; Drug
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Columbus, Ohio • Galveston, Texas

Conditions: Chorioamnionitis
Interventions: Unasyn, Ampicillin/gentamicin; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Stanford, California

Conditions: Maternal; Chorioamnionitis, Affecting Fetus, Early-Onset Sepses, Neonatal
Interventions: EOS Calculator; Diagnostic Test
Lead sponsor: Pediatrix; Other
Eligibility: 35 Weeks and older
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Premature Rupture of Membrane, Induction of Labor Affected Fetus / Newborn
Interventions: Misoprostol Oral Product, Intravenous Oxytocin; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older · Female only
Enrollment: 138 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Preterm Rupture of Membranes
Interventions: mNGS; Diagnostic Test
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Preterm Birth, Premature Rupture of Membranes
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: Not listed
Enrollment: 6,838 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2016
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Preterm Birth
Interventions: Urine samples; Other
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 50 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Preterm Labor, Preterm Birth
Interventions: PAMG-1 immunoassay; Device
Lead sponsor: Mark Santillan; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Preterm Birth, Preterm Labor, Bacteremia, Preterm Premature Rupture of Fetal Membranes
Interventions: Prenatal vitamin-mineral containing 3 mg fluoride, Prenatal vitamin-mineral containing 0 mg fluoride; Drug · Dietary Supplement
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Premature Rupture of Membranes
Interventions: Foley Catheter, Oxytocin; Device · Drug
Lead sponsor: Geisinger Clinic; Other
Eligibility: Female only
Enrollment: 201 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 5
States / cities: Phoenix, Arizona • Newark, Delaware • Allentown, Pennsylvania + 2 more

Conditions: Premature Rupture of Fetal Membranes
Interventions: CRB, Pitocin; Device · Drug
Lead sponsor: Cook Group Incorporated; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 4
States / cities: Tucson, Arizona • Tampa, Florida • Louisville, Kentucky + 1 more

Conditions: Women Admitted to Labor and Delivery for the Management of Preterm Labor and/or Preterm Premature Rupture of Membranes (PPROM)
Interventions: Not listed
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Antenatal Corticosteroids
Interventions: Antenatal corticosteroids; Other
Lead sponsor: St. Louis University; Other
Eligibility: 13 Years to 55 Years · Female only
Enrollment: 182 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Chorioamnionitis
Interventions: saline, ampicillin gentamicin, ampicillin gentamicin clindamycin; Drug
Lead sponsor: United States Naval Medical Center, Portsmouth; Federal
Eligibility: 18 Years to 45 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Portsmouth, Virginia

Conditions: Preterm Premature Ruptured Membranes
Interventions: Azithromycin, Erythromycin; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Preterm Premature Rupture of Membranes
Interventions: Magnesium sulfate; Drug
Lead sponsor: Regional Obstetrical Consultants; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Chattanooga, Tennessee

Conditions: Chorioamnionitis, Intrauterine Infection, Postpartum Endometritis, Puerperal Infection
Interventions: Cervical examination to assess labor; Procedure
Lead sponsor: Eastern Virginia Medical School; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 163 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Norfolk, Virginia

Conditions: Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy), PROM (Pregnancy), Premat Rupture Membranes Preterm Unspec to Length of Time Between Rupture/Labor, Premature Birth
Interventions: Azithromycin Pill, Amoxicillin Pill; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 1 participant
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 3
States / cities: Cleveland, Ohio

Conditions: Fever
Interventions: Not listed
Lead sponsor: MemorialCare; Other
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Long Beach, California • Orange, California

Conditions: Vaginosis, Bacterial, Premature Birth, Birth Weight, Chorioamnionitis
Interventions: oral versus vaginal metronidazole; Drug
Lead sponsor: Centers for Disease Control and Prevention; Federal
Eligibility: 16 Years and older · Female only
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2004
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Labor, Premature, Preterm Premature Rupture of the Membranes, Infection, Inflammation, Chorioamnionitis
Interventions: amniocentesis, N-acetylcysteine or placebo; Procedure · Drug
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2018
U.S. locations: 2
States / cities: New Haven, Connecticut • Columbus, Ohio

Search by objective public record fields.

Intrapartum Study of Sterile and Clean Gloves

Foley Catheter for Labor Induction in Women With Term and Near Term Membrane Rupture

Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus

Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)

Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis

A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator

PROMMO Trial: Oral Misoprostol vs IV Oxytocin

Identification of Microbial DNA in Maternal Plasma After PPROM

Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition

Glycoproteomic Analysis of Urine in Women Undergoing Spontaneous Preterm Delivery

Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women

Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being

FOLCROM Trial: Foley Catheter in Rupture of Membranes

Evaluation of CRB in PROM Patients

Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes

Repeat Antenatal Corticosteroids

Treatment of Chorioamnionitis After Delivery

Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes

Magnesium Sulfate Versus Placebo for Tocolysis in PPROM

Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term

Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age

Evaluation of Fever Occurring in Labor in Patients Receiving Epidural Anesthesia

Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy

N-acetylcysteine in Intra-amniotic Infection/Inflammation