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Showing 1–24 of 59 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Preterm Premature Rupture of Membranes Clear all
Completed No phase listed Observational Accepts healthy volunteers

Identification of Microbial DNA in Maternal Plasma After PPROM

NCT04318470
View directory record Official record
Conditions
Preterm Rupture of Membranes
Interventions
mNGS
Diagnostic Test
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial.

NCT01050647
View directory record Official record
Conditions
Pregnancy Complications
Interventions
17-Hydroxyprogesterone Caproate, Caster Oil injections
Drug · Other
Lead sponsor
Stanford University
Other
Eligibility
Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
2
States / cities
San Jose, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Jun 10, 2026, 2:12 PM EDT
Not listed No phase listed Observational

PROMComplete for Determination of Rupture of Fetal Membranes

NCT02369601
View directory record Official record
Conditions
Fetal Membranes, Premature Rupture
Interventions
non- intervention study
Other
Lead sponsor
Pro-Lab Diagnostics
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Birmingham, Alabama • Indianapolis, Indiana • Dallas, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intrapartum Study of Sterile and Clean Gloves

NCT01852188
View directory record Official record
Conditions
Chorioamnionitis
Interventions
Type of glove used for intrapartum vaginal exams
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older · Female only
Enrollment
507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 17, 2018 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Not applicable Interventional Results available

Evaluation of CRB in PROM Patients

NCT01736852
View directory record Official record
Conditions
Premature Rupture of Fetal Membranes
Interventions
CRB, Pitocin
Device · Drug
Lead sponsor
Cook Group Incorporated
Industry
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
4
States / cities
Tucson, Arizona • Tampa, Florida • Louisville, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Jun 10, 2026, 2:12 PM EDT
Completed No phase listed Observational

Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes

NCT00342667
View directory record Official record
Conditions
Preterm Birth, Pregnancy
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
Up to 45 Years
Enrollment
4,673 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2014
U.S. locations
2
States / cities
Bethesda, Maryland • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

PROMMO Trial: Oral Misoprostol vs IV Oxytocin

NCT04478942
View directory record Official record
Conditions
Premature Rupture of Membrane, Induction of Labor Affected Fetus / Newborn
Interventions
Misoprostol Oral Product, Intravenous Oxytocin
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Not applicable Interventional

Preterm Premature Rupture of Membranes (PPROM): Bed Rest Versus Activity Trial

NCT01544387
View directory record Official record
Conditions
Pregnancy, Pre-term Premature Rupture of Membranes
Interventions
Bed Rest, Activity
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Elmhurst, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2014 · Synced Jun 10, 2026, 2:12 PM EDT
Not yet recruiting Not applicable Interventional

Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury Biomarkers

NCT07610642
View directory record Official record
Conditions
Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion, Neonatal Brain Injury
Interventions
Intrauterine Pressure Catheter, Standard obstetric care at discretion of delivery provider
Device · Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 10, 2026, 2:12 PM EDT
Recruiting Not applicable Interventional

Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus

NCT05893485
View directory record Official record
Conditions
Music Therapy, Preterm Premature Rupture of Membrane (PPROM)
Interventions
Music Therapy Intervention
Behavioral
Lead sponsor
Christina Chianis Reed
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jun 10, 2026, 2:12 PM EDT
Terminated No phase listed Observational

Clinical Evaluation of the AmniSure ROM Test

NCT01847820
View directory record Official record
Conditions
Rupture of Fetal Membranes
Interventions
AmniSure ROM test
Device
Lead sponsor
QIAGEN Gaithersburg, Inc
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
4
States / cities
Fresno, California • Indianapolis, Indiana • Kansas City, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2016 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Phase 2 Interventional

Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy

NCT00153517
View directory record Official record
Conditions
Vaginosis, Bacterial, Premature Birth, Birth Weight, Chorioamnionitis
Interventions
oral versus vaginal metronidazole
Drug
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
16 Years and older · Female only
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Jun 10, 2026, 2:12 PM EDT
Withdrawn Phase 4 Interventional

Intrapartum Fever: Antibiotics Versus no Treatment

NCT03168178
View directory record Official record
Conditions
Chorioamnionitis, Intrapartum Fever, Intra-amniotic Infection
Interventions
Standard Antibiotic Treatment, No Antibiotic Treatment
Drug · Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Jun 10, 2026, 2:12 PM EDT
Terminated Phase 3 Interventional Results available

Treatment of ppROM With Erythromycin vs. Azithromycin Trial

NCT03060473
View directory record Official record
Conditions
Preterm Premature Rupture of Membranes (PPROM)
Interventions
Azithromycin, Erythromycin, Ampicillin, Amoxicillin
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
3
States / cities
Austin, Texas • Galveston, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Jun 10, 2026, 2:12 PM EDT
Recruiting Phase 4 Interventional

Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM

NCT07119398
View directory record Official record
Conditions
Preterm PROM (Pregnancy)
Interventions
Oxytocin plus Foley Catheter, Oxytocin
Combination Product · Drug
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Jun 10, 2026, 2:12 PM EDT
Completed No phase listed Observational

Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes

NCT01975792
View directory record Official record
Conditions
Women Admitted to Labor and Delivery for the Management of Preterm Labor and/or Preterm Premature Rupture of Membranes (PPROM)
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Jun 10, 2026, 2:12 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Magnesium Sulfate Versus Placebo for Tocolysis in PPROM

NCT00463736
View directory record Official record
Conditions
Preterm Premature Rupture of Membranes
Interventions
Magnesium sulfate
Drug
Lead sponsor
Regional Obstetrical Consultants
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 18, 2016 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

FOLCROM Trial: Foley Catheter in Rupture of Membranes

NCT01973036
View directory record Official record
Conditions
Premature Rupture of Membranes
Interventions
Foley Catheter, Oxytocin
Device · Drug
Lead sponsor
Geisinger Clinic
Other
Eligibility
Female only
Enrollment
201 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
5
States / cities
Phoenix, Arizona • Newark, Delaware • Allentown, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2018 · Synced Jun 10, 2026, 2:12 PM EDT
Not listed No phase listed Observational

The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes

NCT04963465
View directory record Official record
Conditions
Preterm Premature Rupture of Membrane, Amniotic Fluid Leakage
Interventions
Ferning on microscopy
Diagnostic Test
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Jun 10, 2026, 2:12 PM EDT
Terminated Not applicable Interventional Results available

Foley Catheter for Labor Induction in Women With Term and Near Term Membrane Rupture

NCT00290199
View directory record Official record
Conditions
Fetal Membranes, Premature Rupture, Labor, Induced/IS
Interventions
Transcervical Foley catheter
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 55 Years · Female only
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
3
States / cities
Birmingham, Alabama • Newark, Delaware • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2017 · Synced Jun 10, 2026, 2:12 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA

NCT04047849
View directory record Official record
Conditions
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth, Preterm PROM (Pregnancy), Preterm Labor
Interventions
Antibiotics, oral Azithromycin and oral Amoxicillin
Drug
Lead sponsor
Woman's
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 10, 2021 · Synced Jun 10, 2026, 2:12 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term

NCT05603624
View directory record Official record
Conditions
Chorioamnionitis, Intrauterine Infection, Postpartum Endometritis, Puerperal Infection
Interventions
Cervical examination to assess labor
Procedure
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Jun 10, 2026, 2:12 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

PPROM Registry (Preterm Premature Rupture of Membranes)

NCT02997345
View directory record Official record
Conditions
Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes, Oligohydramnios, Premature Birth
Interventions
There is no intervention associated with this study.
Other
Lead sponsor
American Alliance for pProm Support
Other
Eligibility
14 Years to 55 Years · Female only
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2030
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jun 10, 2026, 2:12 PM EDT
Completed Phase 1Phase 2 Interventional

N-acetylcysteine in Intra-amniotic Infection/Inflammation

NCT00397735
View directory record Official record
Conditions
Labor, Premature, Preterm Premature Rupture of the Membranes, Infection, Inflammation, Chorioamnionitis
Interventions
amniocentesis, N-acetylcysteine or placebo
Procedure · Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2018
U.S. locations
2
States / cities
New Haven, Connecticut • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Jun 10, 2026, 2:12 PM EDT