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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Preterm Premature Rupture of Membranes (PPROM) Clear all
Not listed No phase listed Observational

The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes

NCT04963465
View directory record Official record
Conditions
Preterm Premature Rupture of Membrane, Amniotic Fluid Leakage
Interventions
Ferning on microscopy
Diagnostic Test
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Jul 21, 2026, 7:20 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes

NCT04516226
View directory record Official record
Conditions
Preterm Premature Rupture of Membrane
Interventions
Vaginal cleansing with chlorhexidine gluconate solution
Other
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Jul 21, 2026, 7:20 PM EDT
Completed Phase 4 Interventional Results available

Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial

NCT05322252
View directory record Official record
Conditions
Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise, Fetal Death, Fetal Demise From Miscarriage, Fetal Death Before 22 Weeks With Retention of Dead Fetus, Pregnancy Loss, Pregnancy Complications
Interventions
Mifepristone, Misoprostol
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jul 21, 2026, 7:20 PM EDT
Recruiting Not applicable Interventional

Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus

NCT05893485
View directory record Official record
Conditions
Music Therapy, Preterm Premature Rupture of Membrane (PPROM)
Interventions
Music Therapy Intervention
Behavioral
Lead sponsor
Christina Chianis Reed
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 7:20 PM EDT
Completed No phase listed Observational

Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes

NCT01975792
View directory record Official record
Conditions
Women Admitted to Labor and Delivery for the Management of Preterm Labor and/or Preterm Premature Rupture of Membranes (PPROM)
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Jul 21, 2026, 7:20 PM EDT
Active, not recruiting Phase 3 Interventional

Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes

NCT06273891
View directory record Official record
Conditions
Premature Rupture of Membrane
Interventions
Erythromycin, Azithromycin
Drug
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Falls Church, Virginia • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jul 21, 2026, 7:20 PM EDT
Active, not recruiting No phase listed Observational

MIRACLE of LIFE Study

NCT06074601
View directory record Official record
Conditions
Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane, Preeclampsia, HELLP, Gestational Hypertension, Gestational Diabetes Mellitus in Pregnancy, Small for Gestational Age at Delivery, Intrauterine Growth Restriction
Interventions
Mirvie Predictive Test for Adverse Pregnancy Outcomes
Diagnostic Test
Lead sponsor
Mirvie
Industry
Eligibility
18 Years and older · Female only
Enrollment
10,000 participants
Timeline
2021 – 2025
U.S. locations
10
States / cities
San Diego, California • Orlando, Florida • New Orleans, Louisiana + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Jul 21, 2026, 7:20 PM EDT
Completed Not applicable Interventional

Ambulation for Latency During Expectant Management of PPROM

NCT04230967
View directory record Official record
Conditions
Preterm Premature Rupture of the Membranes, Pregnancy Complications, Pregnancy, High Risk
Interventions
Ambulation Group, Routine Care
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
12 Years to 55 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Jul 21, 2026, 7:20 PM EDT
Terminated Not applicable Interventional

A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM)

NCT02327637
View directory record Official record
Conditions
Preterm Premature Rupture of the Membranes, Physical Activity
Interventions
Moderate Activity
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2019 · Synced Jul 21, 2026, 7:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Identification of Microbial DNA in Maternal Plasma After PPROM

NCT04318470
View directory record Official record
Conditions
Preterm Rupture of Membranes
Interventions
mNGS
Diagnostic Test
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Jul 21, 2026, 7:20 PM EDT
Terminated Phase 3 Interventional Results available

Treatment of ppROM With Erythromycin vs. Azithromycin Trial

NCT03060473
View directory record Official record
Conditions
Preterm Premature Rupture of Membranes (PPROM)
Interventions
Azithromycin, Erythromycin, Ampicillin, Amoxicillin
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
3
States / cities
Austin, Texas • Galveston, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Jul 21, 2026, 7:20 PM EDT
Completed Not applicable Interventional

Preterm Premature Rupture of Membranes (PPROM): Bed Rest Versus Activity Trial

NCT01544387
View directory record Official record
Conditions
Pregnancy, Pre-term Premature Rupture of Membranes
Interventions
Bed Rest, Activity
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Elmhurst, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2014 · Synced Jul 21, 2026, 7:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cervical Ripening in Premature Rupture of Membranes

NCT02314728
View directory record Official record
Conditions
Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
Interventions
Misoprostol, Oxytocin
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
15 Years to 50 Years · Female only
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 9, 2021 · Synced Jul 21, 2026, 7:20 PM EDT
Withdrawn Phase 3 Interventional

Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes

NCT01556334
View directory record Official record
Conditions
Preterm Premature Ruptured Membranes
Interventions
Azithromycin, Erythromycin
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jul 21, 2026, 7:20 PM EDT
Not yet recruiting Phase 4 Interventional

Extended Azithromycin Treatment in Prelabor Rupture of Membranes

NCT07669207
View directory record Official record
Conditions
Preterm Prelabor Rupture of Membranes, PPROM
Interventions
Azithromycin (Azithro), Standard Azithromycin Dosing
Drug
Lead sponsor
Alexa Henderson
Other
Eligibility
Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 21, 2026, 7:20 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

PPROM Registry (Preterm Premature Rupture of Membranes)

NCT02997345
View directory record Official record
Conditions
Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes, Oligohydramnios, Premature Birth
Interventions
There is no intervention associated with this study.
Other
Lead sponsor
American Alliance for pProm Support
Other
Eligibility
14 Years to 55 Years · Female only
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2030
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jul 21, 2026, 7:20 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Magnesium Sulfate Versus Placebo for Tocolysis in PPROM

NCT00463736
View directory record Official record
Conditions
Preterm Premature Rupture of Membranes
Interventions
Magnesium sulfate
Drug
Lead sponsor
Regional Obstetrical Consultants
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 18, 2016 · Synced Jul 21, 2026, 7:20 PM EDT
Recruiting Phase 4 Interventional

Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM

NCT07119398
View directory record Official record
Conditions
Preterm PROM (Pregnancy)
Interventions
Oxytocin plus Foley Catheter, Oxytocin
Combination Product · Drug
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Jul 21, 2026, 7:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Digital vs. Speculum Exams for PPROM

NCT05773014
View directory record Official record
Conditions
PPROM
Interventions
Speculum Exams, Digital Exams
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Jul 21, 2026, 7:20 PM EDT
Completed Phase 4 Interventional

Azithromycin Dose and PPROM Treatment: a Pilot Randomized Controlled Trial

NCT04294069
View directory record Official record
Conditions
Preterm Premature Rupture of Membrane
Interventions
Azithromycin 500 mg, Azithromycin Oral Product
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
14 Years to 65 Years · Female only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 21, 2026, 7:20 PM EDT
Terminated No phase listed Observational

Clinical Evaluation of the AmniSure ROM Test

NCT01847820
View directory record Official record
Conditions
Rupture of Fetal Membranes
Interventions
AmniSure ROM test
Device
Lead sponsor
QIAGEN Gaithersburg, Inc
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
4
States / cities
Fresno, California • Indianapolis, Indiana • Kansas City, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2016 · Synced Jul 21, 2026, 7:20 PM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?

NCT02939742
View directory record Official record
Conditions
PPROM, Respiratory Distress Syndrome in Premature Infants
Interventions
Betamethasone, Placebo
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 21, 2026, 7:20 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA

NCT04047849
View directory record Official record
Conditions
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth, Preterm PROM (Pregnancy), Preterm Labor
Interventions
Antibiotics, oral Azithromycin and oral Amoxicillin
Drug
Lead sponsor
Woman's
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 10, 2021 · Synced Jul 21, 2026, 7:20 PM EDT
Completed No phase listed Observational

Repeat Antenatal Corticosteroids

NCT03133104
View directory record Official record
Conditions
Antenatal Corticosteroids
Interventions
Antenatal corticosteroids
Other
Lead sponsor
St. Louis University
Other
Eligibility
13 Years to 55 Years · Female only
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced Jul 21, 2026, 7:20 PM EDT