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Conditions: Primary Prevention, Healthy Aging, Quality of Life, Decision Support Techniques
Interventions: Individualized preventive care recommendations (decision tool); Behavioral
Lead sponsor: Glen Taksler; Other
Eligibility: 40 Years to 75 Years
Enrollment: 721 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Depression, Healthy, Osteopenia, Osteoporosis
Interventions: Alendronate; Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 21 Years to 45 Years · Female only
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2007
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Neoplasm Cervix
Interventions: Curcumin C3 Complex, Placebo; Drug
Lead sponsor: Lisa Flowers; Other
Eligibility: 21 Years and older · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Hypertension, Dyslipidemia, Diabetes Mellitus, Obesity, Cardiovascular Disease
Interventions: Experimental - 12 Week P3-EX Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants, Active Control - 12 Week ACSM-PAVS Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants; Behavioral
Lead sponsor: University of Connecticut; Other
Eligibility: 18 Years to 64 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 3
States / cities: Farmington, Connecticut • Hartford, Connecticut • Storrs, Connecticut

Conditions: Cardiomyopathy Due to Drug, Heart Failure, Systolic
Interventions: Lisinopril, Placebo Oral Tablet; Drug
Lead sponsor: Ascension Health; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: Grand Blanc, Michigan

Conditions: Mycoses, Mycobacterium Avium-Intracellulare Infection, HIV Infections
Interventions: Azithromycin, Rifabutin, Fluconazole; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 12 Years and older
Enrollment: 720 participants
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 12
States / cities: Los Angeles, California • Orange, California • San Diego, California + 7 more

Conditions: Genetic Predisposition to Disease, Hereditary Diseases
Interventions: Genome Sequencing; Genetic
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 0 Months to 12 Months
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 4
States / cities: Birmingham, Alabama • Boston, Massachusetts • Royal Oak, Michigan + 1 more

Conditions: Aging, Mortality, All-cause Mortality, Life Expectancy, Cardiovascular Diseases, Neoplasms, Cognitive Dysfunction, Metabolic Syndrome, Frailty, Musculoskeletal Disease, Neurodegenerative Disease, Dementia, Activities of Daily Living, Health Related Quality of Life, Environmental Exposure, Occupational Diseases, Health Equity, Social Determinants of Health, Physical Disability
Interventions: Multi-Domain Ecological and Clinical Data Linkage; Other
Lead sponsor: Longevity Metrics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 1,000,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2099
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: HIV Infections
Interventions: gp160 Vaccine (Immuno-AG); Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Ends 1993
U.S. locations: 3
States / cities: St Louis, Missouri • Pittsburgh, Pennsylvania • Nashville, Tennessee

Conditions: Asthma
Interventions: insurance navigation; Behavioral
Lead sponsor: Harvard Pilgrim Health Care; Other
Eligibility: 4 Years to 64 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Wellesley, Massachusetts

Conditions: Asthma
Interventions: HDHP with PDL; Other
Lead sponsor: Harvard Pilgrim Health Care; Other
Eligibility: 4 Years to 64 Years
Enrollment: 12,238 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Wellesley, Massachusetts

Conditions: HIV Infections, Pregnancy Complications, Infectious
Interventions: Adherence assessment; Behavioral
Lead sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group; Network
Eligibility: 14 Years and older · Female only
Enrollment: 3,090 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2013
U.S. locations: 75
States / cities: Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 38 more

Conditions: Cancer
Interventions: Capacity Enhancement, Standard Dissemination; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 21 Years and older
Enrollment: 348 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 3
States / cities: Boston, Massachusetts • Medford, Massachusetts

Conditions: Seizures, Primary Motor Cortex, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases, Adult, Brain Metastases From Extra-cranial Solid Tumors
Interventions: Levetiracetam (Keppra); Drug
Lead sponsor: Ayal A. Aizer, MD; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Migraine
Interventions: levetiracetam, Transcranial Magnetic Stimulation; Drug · Procedure
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pediatric Obesity, Preventive Medicine, Mentoring, Food Supply
Interventions: Patient Reported Outcome Well Child Visit, Patient Reported Outcome Well Child Visit + Food Care; Behavioral
Lead sponsor: Geisinger Clinic; Other
Eligibility: 20 Months to 59 Months
Enrollment: 2,040 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Danville, Pennsylvania

Conditions: Physical Activity
Interventions: App, Wearable Device, Automated Motivational Message, Personalized Motivational Message; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 20 Years to 80 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Vaccines, Preventive Medicine
Interventions: Information Sheet, High-touch connect; Other
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years and older
Enrollment: 176 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: HIV Infections
Interventions: Hepatitis A Vaccine (Inactivated); Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 2 Years to 21 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 47
States / cities: Birmingham, Alabama • Phoenix, Arizona • La Jolla, California + 34 more

Conditions: Ischemic Stroke, Transient Ischemic Attack
Interventions: Physician stroke guideline adherence, Stroke Self Management, Attention Control Group; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 174 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 2
States / cities: Indianapolis, Indiana • Houston, Texas

Conditions: Tobacco Use, Drug Use, Adolescent Behavior, Alcohol Use, Sexual Risk Behavior
Interventions: S4E, Attention-Matched Control Group; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 13 Years to 21 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Ypsilanti, Michigan

Conditions: HIV Infections
Interventions: Aluminum hydroxide, QS-21, rgp120/HIV-1MN; Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Ends 1995
U.S. locations: 4
States / cities: St Louis, Missouri • Rochester, New York • Pittsburgh, Pennsylvania + 1 more

Conditions: Preventative Medicine
Interventions: Telehealth: Personalized Preventative Medicine Strategies, TeleHealth: Preventative Medicine Education; Behavioral
Lead sponsor: Xavier University of Louisiana.; Other
Eligibility: 18 Years to 55 Years
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Migraine
Interventions: Zavegepant; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Phoenix, Arizona

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Personalized Disease Prevention

Bone Loss in Premenopausal Women With Depression

Topical Curcumin for HPV Related Cervical Disease

A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy.

A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients

Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants

Human Observatory Study

A Phase I Multicenter Clinical Trial to Evaluate the Safety and Immunogenicity of Vaccinia Derived HIV-1 Recombinant Envelope Glycoprotein (gp160) of Human Immunodeficiency Virus: Evaluation of Accelerated Schedules

Asthma in Families Facing Out-of-pocket Requirements Due to COVID-19

Asthma in Families Facing Out-of-pocket Requirements With Deductibles

Prenatal and Postnatal Studies of Interventions for Prevention of Mother-To-Child Transmission

Promoting Organizational Capacity to Implement Cancer Control Programs Among Latino Churches

Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

A Clinical Study Examining the Safety and Effectiveness of a New Medication (Keppra®) for the Prevention of Migraine Headaches

Patient-Clinic-Community Integration to Prevent Obesity Among Rural Preschool Children

Exercise is Medicine at Emory Seavey Internal Medicine Clinic

Increasing Men's Engagement in Preventive Healthcare Through an Enhanced Cocoon Vaccination Strategy

A Study on the Rate of Opportunistic (AIDS-Related) Infections Among HIV-Positive Children Who Have Stopped Taking Their OI Preventive Medications

Adapting Tools to Implement Stroke Risk Management to Veterans

Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention

A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of rgp120/HIV-1MN (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults.

Using a Telehealth and Shared Decision-Making Model to Address Preventative Medicine Strategies Among Communities in Louisiana

Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications