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ClinicalTrials.gov public records Last synced Oct 21, 2026, 7:35 AM EDT

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Showing 265–288 of 291 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Problem Drinking Clear all
Completed Phase 2 Interventional Results available

Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence

NCT00142818
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcoholism, Cocaine-Related Disorders
Interventions
Naltrexone, Modafinil, Placebo
Drug
Lead sponsor
Kyle Kampman
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CARES: A Mobile Health Program for Alcohol Risk Reduction

NCT03927482
View directory record Official record
Conditions
Alcohol Abuse
Interventions
CARES mobile smart phone app, Check Your Drinking
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 29 Years
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Alcohol Pharmacotherapy for HIV+ Prisoners

NCT01077310
View directory record Official record
Conditions
Alcohol Dependence, Problem Drinking, Hazardous Drinking, Human Immunodeficiency Virus, AIDS
Interventions
Vivitrol- Intramuscular naltrexone (depot-formulation), Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 21, 2026, 7:35 AM EDT
Active, not recruiting Not applicable Interventional

Testing the Impact of Thrive App Versions on Alcohol Use and Posttraumatic Stress After Recent Sexual Assault

NCT06444295
View directory record Official record
Conditions
Posttraumatic Stress Symptom, Alcohol Drinking, Alcohol Problem
Interventions
Activity scheduling, Cognitive restructuring, Coaching calls, Non-core intervention components
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
464 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Phase 1 Interventional

Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis

NCT03416751
View directory record Official record
Conditions
Cirrhosis, Alcohol Abuse
Interventions
Fecal Microbial Transplant, Placebo
Biological · Other
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Oct 21, 2026, 7:35 AM EDT
Recruiting Not applicable Interventional

Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building

NCT07217795
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), PTSD
Interventions
CBT + expressive writing, Wait-List Control
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Phase 2 Interventional

The iHealth Study in College Students

NCT00183131
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Dependence, Unhealthy Alcohol Use, Risky Alcohol Consumption Amounts, Hazardous Alcohol Use
Interventions
Brief Personalized Feedback
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
4,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2010 · Synced Oct 21, 2026, 7:35 AM EDT
Terminated Not applicable Interventional Results available

Topiramate for Alcohol Use in Posttraumatic Stress Disorder

NCT01408641
View directory record Official record
Conditions
Alcohol Dependence, Alcoholism, Alcohol Abuse, Alcohol Use Disorder, PTSD, Posttraumatic Stress Disorder
Interventions
Topiramate, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 64 Years · Male only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders

NCT01338506
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
Interventions
Concurrent Treatment with Prolonged Exposure (COPE)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Remote Brief Intervention and Referrals to Treatment Service for Alcohol

NCT02622984
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Dependence
Interventions
RBIRT, SBIRT
Behavioral
Lead sponsor
Polaris Health Directions
Industry
Eligibility
18 Years and older
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Oct 21, 2026, 7:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Greek Connections Study

NCT07839026
View directory record Official record
Conditions
Heavy Episodic Drinking, Problem Drinking, College Student Drinking
Interventions
Alcohol-free Social Activities Program
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 29 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Phase 2 Interventional

Screening and Brief Intervention in the ED Among Mexican-origin Young Adults

NCT02056535
View directory record Official record
Conditions
Problem Drinking, Alcohol Dependence
Interventions
Brief Motivational Intervention
Behavioral
Lead sponsor
Public Health Institute, California
Other
Eligibility
18 Years to 30 Years
Enrollment
698 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2014 · Synced Oct 21, 2026, 7:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Alcohol Early Intervention for Freshmen

NCT00852033
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Brief Motivational Intervention (BMI), Parent Based Intervention plus booster, Combined brief motivational intervention and parent based intervention plus boosters for both interventions, Assessment only
Behavioral · Other
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
17 Years to 20 Years
Enrollment
1,014 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 26, 2009 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional

fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults

NCT01320748
View directory record Official record
Conditions
Substance Abuse, Substance Dependence, Alcohol Abuse, Drug Use, Relapse
Interventions
Dual Processing, Relapse Prevention
Behavioral
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 30, 2018 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional

Pilot Study of a Text Message Platform to Reduce Risky Drinking in Young Adults

NCT01197352
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Consumption, Drinking Behavior
Interventions
Motivational and Normative Feedback, Self-Awareness
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 24 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2012 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Gamified, Social Media Inspired Personalized Normative Feedback Alcohol Intervention for Sexual Minority Women

NCT03884478
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Abuse, Alcohol; Harmful Use
Interventions
Personalized Normative Feedback
Behavioral
Lead sponsor
Loyola Marymount University
Other
Eligibility
21 Years to 55 Years · Female only
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional

Mindfulness for Alcohol Abusing Offenders

NCT03883646
View directory record Official record
Conditions
Alcohol Abuse, Criminal Behavior
Interventions
Mindfulness, Relapse Prevention
Behavioral
Lead sponsor
The Mind Research Network
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
392 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Helping Families Help Veterans With PTSD and Alcohol Abuse: An RCT of VA-CRAFT

NCT01678196
View directory record Official record
Conditions
PTSD, Alcohol Abuse
Interventions
VA-CRAFT, Control
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users

NCT02740582
View directory record Official record
Conditions
Alcohol Abuse, Impulsive Behavior
Interventions
Tolcapone, Placebo
Drug
Lead sponsor
Jennifer Mitchell
Other
Eligibility
21 Years to 40 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Berkeley, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Study of the Effects of Motivational Enhancement Therapy on Alcohol Use in Chronic Hepatitis C Patients

NCT00596960
View directory record Official record
Conditions
Alcohol Dependence, Chronic Hepatitis C
Interventions
Motivational Enhancement Therapy (MET), Health education
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Minneapolis, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 28, 2014 · Synced Oct 21, 2026, 7:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

DRT Mobile Intervention to Increase Safe Drinking

NCT05098639
View directory record Official record
Conditions
Alcohol; Use, Problem
Interventions
BASICS, Deviance Regulation Theory (DRT)
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 26 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Oct 21, 2026, 7:35 AM EDT
Withdrawn Phase 1 Interventional

Trial of Computerized SBI to Reduce Teen Alcohol Use

NCT01784627
View directory record Official record
Conditions
Alcohol Abuse, Cannabis Abuse, Nicotine Dependence
Interventions
c-ASBI
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
9 Years to 20 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
6
States / cities
Boston, Massachusetts • Cambridge, Massachusetts • Lexington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2016 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Not applicable Interventional

Theta Burst Stimulation as a Tool to Decrease Drinking in Treatment-seeking Alcohol Users

NCT04154111
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Abuse, Alcohol Dependence, Craving
Interventions
Real TBS to the vmPFC, Sham TBS to the vmPFC, Real TBS to the dlPFC, Sham TBS to the dlPFC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 75 Years
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 21, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Impact of a Brief Motivational Interview on Drinking Behaviors of At Risk Drinkers Screened in the Emergency Room

NCT00183183
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Screening and Brief Intervention
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
1,137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
15
States / cities
Los Angeles, California • San Diego, California • Denver, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated May 24, 2010 · Synced Oct 21, 2026, 7:35 AM EDT