Independent directory Public ClinicalTrials.gov records United States
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Showing 97–120 of 346 matching trials from the live ClinicalTrials.gov search.
Conditions
Dementia, Cognitive Impairment, Cognitive Decline, Alzheimer Disease
Interventions
MyCog
Diagnostic Test
Lead sponsor
Northwestern University
Other
Eligibility
45 Years and older
Enrollment
57,738 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Cognitive Decline
Interventions
Not listed
Lead sponsor
Oregon Health and Science University
Other
Eligibility
65 Years to 89 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Conditions
Cognitive Dysfunction, Lewy Body Disease, Synucleinopathies, Amyloid
Interventions
Donanemab, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
55 Years to 85 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
42
States / cities
Chandler, Arizona • Scottsdale, Arizona • Carlsbad, California + 36 more
Conditions
Alzheimer's Disease
Interventions
Resonator, Placebo
Device
Lead sponsor
pico-tesla Magnetic Therapies, LLC
Industry
Eligibility
55 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Denver, Colorado • Clearwater, Florida
Conditions
Cognitive Decline, Mucopolysaccharidosis I, Hurler-Scheie Syndrome, Scheie Syndrome, Lysosomal Storage Disease
Interventions
laronidase
Drug
Lead sponsor
Patricia I. Dickson, M.D.
Individual
Eligibility
6 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
3
States / cities
Oakland, California • Torrance, California • Minneapolis, Minnesota
Active, not recruiting Phase 2 Interventional

High-dose Vitamin D Supplements in Older Adults

NCT03613116
Conditions
Vitamin D Deficiency, Cognitive Decline
Interventions
Vitamin D3
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
65 Years to 90 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Walnut Creek, California
Conditions
Alzheimer Disease, Early Onset, Alzheimer Disease, Alzheimer Dementia, Mild Cognitive Impairment, Memory Disorders, Memory Loss, Memory Impairment, Memory Disorders, Age Related, Alzheimer Disease, Late Onset, Cognitive Impairment, Dementia, Mild, Dementia, Alzheimer Type, Cognitive Decline
Interventions
GammaSense Stimulation System (non-invasive, non-significant risk)
Device
Lead sponsor
Cognito Therapeutics, Inc.
Industry
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Newton, Massachusetts
Conditions
Alzheimer's Dementia
Interventions
Resonator
Device
Lead sponsor
pico-tesla Magnetic Therapies, LLC
Industry
Eligibility
55 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Tampa, Florida
Conditions
Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Dementia
Interventions
Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine), PCP
Drug · Other
Lead sponsor
Rong Zhang
Other
Eligibility
60 Years to 85 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Childhood Hematopoietic and Lymphatic System Neoplasm, Childhood Malignant Solid Neoplasm
Interventions
Interview, Music Therapy, Survey Administration
Other · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
12 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Scottsdale, Arizona
Conditions
Cognitive Impairment, Cognitive Decline, Cognition Disorders in Old Age, Well-Being, Psychological, Inflammation, Cognitive Fun
Interventions
LasoperinTM, Placeo
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
30 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Saint Charles, Missouri
Completed Not applicable Interventional Accepts healthy volunteers

Brain Vascular and Neurocognitive Health

NCT06497413
Conditions
Cognitive Decline, Cognitive Dysfunction, Alzheimer Disease, Vascular Disease, Peripheral
Interventions
Transcranial Photobiomodulation, Transcranial Photobiomodulation helmet (Neuradiant 1070 Plus) with no light administered
Device
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Arlington, Texas
Completed Phase 1 Interventional Accepts healthy volunteers

18F-AV-1451 PET Imaging in Participants Enrolled in the LEARN Study

NCT02850146
Conditions
Cognition Disorders
Interventions
18F-AV-1451
Drug
Lead sponsor
University of Southern California
Other
Eligibility
65 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
7
States / cities
Phoenix, Arizona • New Haven, Connecticut • The Villages, Florida + 4 more
Conditions
Cognitive Decline
Interventions
ProdromeNeuro Omega 3 Oil Nutritional Supplement
Dietary Supplement
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
35 Years to 65 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Santa Monica, California
Recruiting Not applicable Interventional Accepts healthy volunteers

Polyphenols and Cognitive Decline

NCT06507254
Conditions
Cognitive Decline, Cognitive Dysfunction
Interventions
Polyphenol Supplement, Placebo Supplement
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Alzheimer Disease (AD), Cognitive Decline
Interventions
Educational materials on the Alzheimer's disease assay, Alzheimer's disease assay results
Other
Lead sponsor
Qure Healthcare, LLC
Industry
Eligibility
Not listed
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
St Louis, Missouri
Terminated Phase 1 Interventional Accepts healthy volunteers Results available

Flortaucipir 18F PET Imaging in BIOCARD Study

NCT03052972
Conditions
Cognitive Decline
Interventions
Flortaucipir F18, Brain PET scan
Drug · Procedure
Lead sponsor
Avid Radiopharmaceuticals
Industry
Eligibility
Not listed
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Not applicable Interventional Accepts healthy volunteers

Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline

NCT04009382
Conditions
Cognitive Decline
Interventions
Baduanjin Exercise, Cognitive Fitness Program
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 80 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Conditions
Cognitive Decline
Interventions
Souvenaid, Placebo
Drug · Other
Lead sponsor
University of Miami
Other
Eligibility
55 Years to 89 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Miami, Florida
Recruiting No phase listed Observational Accepts healthy volunteers

Cognitive Decline Following Deep Brain Stimulation

NCT05822388
Conditions
Parkinson Disease, Movement Disorders
Interventions
Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet, Healthy
Interventions
XO Genius
Dietary Supplement
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 50 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Arlington, Texas
Conditions
Alzheimer Disease, Mild Cognitive Impairment
Interventions
Data-Driven Clinical Recommendations, Coached Data-Driven Clinical Recommendations
Behavioral
Lead sponsor
Saint John's Cancer Institute
Other
Eligibility
50 Years to 80 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Completed Not applicable Interventional Results available

Happy Older Latinos Are Active - Cognitive Decline

NCT04791709
Conditions
Cognitive Decline
Interventions
Happy Older Latinos are Active (HOLA)
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Miami, Florida
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural Control of Gait & Navigation in ADRD

NCT06501820
Conditions
Aging
Interventions
Transcranial direct current stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Gainesville, Florida